Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long‐COVID – A multinational ICOSS study

Merikanto, Ilona; Dauvilliers, Yves; Chung, Frances; Holzinger, Brigitte; Gennaro, Luigi De; Wing, Yun Kwok; Korman, Maria; Partinen, Markku; Bjelajac, Adrijana Koščeć; Bjorvatn, Bjørn; Chan, Ngan Yin; Hrubos‐Strøm, Harald; Inoue, Yuichi; Kirov, Roumen; Landtblom, Anne‐Marie; Léger, Damien; Matsui, Kentaro; Morin, Charles M.; Mota-Rolim, Sérgio A.; Nadorff, Michael R.; Penzel, Thomas; Plazzi, Giuseppe; Reis, Cátia; Yordanova, Juliana; Kortesoja, Laura; Merikanto,; Santis, Alessandra De; Bolstad, Courtney J.; Nadorff,; Macêdo, Tainá; Cunha, Ana Suely; Mota‐Rolim,; Nierwetberg, Franziska; Agami, Dor; Schwartsberg, Elizabeth; Korman,; Koumanova, Silvia; Lyamova, Laura; Yordanova,; Kristoffersson, Anna; Berntsson, Shala Ghaderi; Liu, Yaping; Ferreira, Diva; Avdagic, Selma Cvijetic; Delale, Eva Anđela; Macan, Jelena; Ross, Biserka; Vidovic, Domagoj; Lyamova, Vasil Kolev

doi:10.1111/jsr.13542

Cited by 24 publications

(23 citation statements)

References 59 publications

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“…The ICOSS‐group conducted (May–Dec 2021) an international harmonised online survey in 16 countries (Austria, Brazil, Bulgaria, Canada, Hong Kong/China, Croatia, Finland, France, Germany, Israel, Italy, Japan, Norway, Portugal, Sweden, USA; Merikanto et al, 2021 ). The study conforms to recognised standards by the Declaration of Helsinki.…”

Section: Methodsmentioning

confidence: 99%

“…The main aim of the International COVID Sleep Study‐II in 2021 (ICOSS‐II) was to study the role of sleep and wake disturbances in PASC, as sleep problems have increased significantly during the pandemic (Merikanto et al, 2021 ; Partinen et al, 2021 ). Accordingly, we examined the prevalence and nature of sleep problems along with other previously defined PASC symptoms lasting at least 3 months in relation to C‐19 severity with non‐C‐19 controls.…”

Section: Introductionmentioning

confidence: 99%

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Sleep symptoms are essential features of long‐COVID– Comparing healthy controls withCOVID‐19 cases of different severity in the internationalCOVIDsleep study (ICOSS‐II)

Merikanto

Dauvilliers

Chung

et al. 2022

Journal of Sleep Research

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Many people report suffering from post-acute sequelae of COVID-19 or "long-COVID", but there are still open questions on what actually constitutes long-COVID and how prevalent it is. The current definition of post-acute sequelae of COVID-19 is based on voting using the Delphi-method by the WHO post-COVID-19 working group. It emphasizes long-lasting fatigue, shortness of breath and cognitive dysfunction as the core symptoms of post-acute sequelae of COVID-19. In this international survey study consisting of 13,628 subjects aged 18-99 years from 16 countries of Asia, Europe, North America and South America (May-Dec 2021), we show that post-acute sequelae of COVID-19 symptoms were more prevalent amongst the more severe COVID-19 cases, i.e. those requiring hospitalisation for COVID-19. We also found that long-lasting sleep symptoms are at the core of post-acute sequelae of COVID-19 and associate with the COVID-19 severity when COVID-19 cases are compared with COVID-negative cases. Specifically, fatigue (61.3%), insomnia symptoms (49.6%) and excessive daytime sleepiness (35.8%) were highly prevalent amongst respondents reporting long-lasting symptoms after hospitalisation for COVID-19. Understanding the importance of sleep-related symptoms in post-acute

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sleep symptoms are essential features of long‐COVID– Comparing healthy controls withCOVID‐19 cases of different severity in the internationalCOVIDsleep study (ICOSS‐II)

Merikanto

Dauvilliers

Chung

et al. 2022

Journal of Sleep Research

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“…A second survey was done to answer the important questions related to COVID-19 and comorbidities, also addressing the long-COVID-19 issue. 78 …”

Section: Limitationsmentioning

confidence: 99%

Nightmares in People with COVID-19: Did Coronavirus Infect Our Dreams?

Scarpelli¹,

Nadorff²,

Bjorvatn³

et al. 2022

NSS

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Introduction A growing number of studies have demonstrated that the coronavirus disease-19 (COVID-19) pandemic has severely affected sleep and dream activity in healthy people. To date, no investigation has examined dream activity specifically in COVID-19 patients. Methods As part of the International COVID-19 Sleep Study (ICOSS), we compared 544 COVID-19 participants with 544 matched-controls. A within-subjects comparison between pre-pandemic and pandemic periods computed separately for controls and COVID-19 participants were performed on dream recall and nightmare frequency (DRF; NF). Also, non-parametric comparisons between controls and COVID-19 participants were carried out. Further, we compared psychological measures between the groups collected during pandemic. Ordinal logistic regression to detect the best predictors of NF was performed. Results We found that people reported greater dream activity during the pandemic. Comparisons between controls and COVID-19 participants revealed a) no difference between groups concerning DRF in the pre-pandemic period and during the pandemic; b) no difference between groups concerning nightmare frequency in the pre-pandemic period; and c) COVID-19 participants reported significantly higher NF than controls during pandemic (p = 0.003). Additionally, we showed that a) anxiety, depression, post-traumatic stress-disorder (PTSD) symptom scores were higher in COVID-19 participants than controls; and b) quality of life and health as well as wellbeing (WHO-5) scores were significantly higher in controls than COVID-19 participants. Finally, ordinal logistic regression indicates that DRF (p < 0.001), PTSD (p < 0.001), anxiety (p = 0.018), insomnia (p = 0.039), COVID-19 severity (p = 0.014), sleep duration (p = 0.003) and age (p = 0.001) predicted NF. Discussion Our work shows strong associations between increased nightmares in those reporting having had COVID-19. This suggests that the more that people were affected by COVID-19, the greater the impact upon dream activity and quality of life.

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“…Differenzierte Analysen der Art der Schlafstörung sind bislang rar. Eine multinationale Fragebogenerhebung zur Schlafphänotypisierung vor und nach SARS-CoV2-Infektion und zu Long-COVID (ICOSS) wird diesbezüglich wertvolle Daten liefern [ 53 ]. Entsprechend der klinischen Beobachtung hypersomnischer Beschwerden bei einigen Long-COVID-Patienten quantifizierten Boesl et al.…”

Section: Schlafstörungenunclassified

Kognitive Störungen und Schlafstörungen bei Long-COVID

2022

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Hintergrund In den letzten 2 Jahren der COVID-19(„coronavirus disease 2019“)-Pandemie ist das Wissen um Langzeitfolgen der Erkrankung, das sog. „Long-COVID“, rapide gewachsen. Es bleiben jedoch noch viele Fragen offen, v. a. was die Ursachen überdauernder Beschwerden und ihre Prognose betrifft. Kognitive Störungen und Schlafstörungen gehören zu den häufig beklagten Beschwerden. Beide gehen mit starkem Leidensdruck und deutlicher Alltagsbeeinträchtigung einher. Ziel der Arbeit Wie ist die Datenlage zum Auftreten kognitiver Störungen und Schlafstörungen bei Long-COVID? Welches sind Einflussfaktoren und was ist bekannt zum Verlauf und zu möglichen zugrunde liegenden Mechanismen? Welche Therapieoptionen gibt es? Material und Methode In einem narrativen Review werden die wichtigsten Befunde zu kognitiven Störungen und Schlafstörungen bei Long-COVID dargestellt. Es wird ein Überblick gegeben über die Kohortenstudien mit Daten zu Prävalenz und Einflussfaktoren beider Symptomkomplexe. Es werden derzeitige Kenntnisse und Hypothesen zu pathophysiologischen Mechanismen dargestellt und ein Ausblick auf Behandlungsansätze gegeben. Ergebnisse Etwa ein Fünftel der Betroffenen berichtet mehr als 3 Monate nach einer SARS-CoV-2(„severe acute respiratory syndrome coronavirus 2“)-Infektion über kognitive Einschränkungen, etwa ein Drittel über Schlafstörungen, wobei es neben insomnischen auch zu hypersomnische Beschwerden kommt. Kognitive Störungen und Schlafstörungen treten bei Betroffenen aller Schweregrade auf. Es gibt Hinweise auf eine Besserung kognitiver Defizite im Verlauf, allerdings sind weitere Längsschnittstudien notwendig. Diskussion Neben der Prognose sind die zugrunde liegenden Krankheitsmechanismen noch unzureichend verstanden. Zudem besteht großer Forschungsbedarf zur Wirksamkeit und zu spezifischen Wirkfaktoren therapeutischer Interventionen .

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Disturbances in sleep, circadian rhythms and daytime functioning in relation to coronavirus infection and Long‐COVID – A multinational ICOSS study

Cited by 24 publications

References 59 publications

Sleep symptoms are essential features of long‐COVID– Comparing healthy controls withCOVID‐19 cases of different severity in the internationalCOVIDsleep study (ICOSS‐II)

Sleep symptoms are essential features of long‐COVID– Comparing healthy controls withCOVID‐19 cases of different severity in the internationalCOVIDsleep study (ICOSS‐II)

Nightmares in People with COVID-19: Did Coronavirus Infect Our Dreams?

Kognitive Störungen und Schlafstörungen bei Long-COVID

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