Disturbances in primary dental enamel in Polish autistic children

Kurek, Marta; Borowska-Strugińska, Beata; Lubowiedzka-Gontarek, Beata; Rosset, Iwona; Żądzińska, Elżbieta

doi:10.1038/s41598-020-69642-3

Cited by 3 publications

(1 citation statement)

References 79 publications

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“…Moreover, the identification of stress markers, such as Accentuated Lines (ALs, more pronounced striae of Retzius) and the Neonatal Line (NNL, an AL that forms at birth), allows us to identify respectively the occurrence of physiological stressors during dental development and the birth event [9,[37][38][39][40][41][42][43][44][45]. These latter lines act as permanent records of physiological stress events above a certain thresholdincluding birth, illnesses, and nutritional deficiencieswhich are permanently etched within the enamel's microstructure during its formation [11,[46][47][48][49].…”

Section: Introductionmentioning

confidence: 99%

Enamel histomorphometry, growth patterns and developmental trajectories of the first deciduous molar in an Italian early medieval skeletal series

Magri,

Higgins,

Lugli

et al. 2024

Preprint

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Understanding the growth patterns and developmental trajectories of teeth during early life stages provides valuable insights into the ontogeny of individuals, particularly in archaeological populations where such information is scarce. This study focuses on first deciduous molars, specifically investigating crown formation times and daily secretion rates, through histological analysis. A total of 34 teeth from the Early Medieval necropolises of Casalmoro and Guidizzolo (Mantua, Lombardy, northern Italy) were analysed assessing growth parameters and identifying possible differences between sites and between sexes, which are determined through proteomic analysis. Furthermore, a robust linear regression model relating prism length and secretion time was built to estimate growth rates also in teeth in which the finest incremental markings are not visible. The daily secretion rates (DSR) in inner enamel showed a high homogeneity between dental arches, sexes and the two sites. Values fall within the known range reported in the literature for the same tooth class in archaeological populations. However, a difference in DSR was observed when compared with modern sample published values. Crown formation times and age at crown completion is different between dental arches, with maxillary first molars initiating their matrix apposition earlier than mandibular molars as formerly reported. However, no significant differences were highlighted in association with sex. This study expands our understanding of the growth and development of first deciduous molars in a medieval population, providing valuable insights into growth trajectories specific to the dental arch. These findings highlight the need for extensive investigations using similar methodologies to attain more accurate and comprehensive information about the developmental patterns of first deciduous molars and underscore the potential use of proteomic analysis to explore deciduous teeth microstructure even in archaeological populations.

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Section: Introductionmentioning

confidence: 99%

Enamel histomorphometry, growth patterns and developmental trajectories of the first deciduous molar in an Italian early medieval skeletal series

Magri,

Higgins,

Lugli

et al. 2024

Preprint

View full text Add to dashboard Cite

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Enamel incremental markings in the deciduous teeth of children from the Early Bronze and modern ages

Šipovac

Petrović

Amzirkov

et al. 2023

Archives of Oral Biology

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Association Between Measures Derived From Children's Primary Exfoliated Teeth and Psychopathology Symptoms: Results From a Community-Based Study

Dunn¹,

Mountain²,

Davis³

et al. 2022

Front. Dent. Med

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Mental disorders are among the most disabling health conditions globally. However, there remains a lack of valid, reliable, noninvasive, and inexpensive biomarkers to identify (at an early age) people who are at the greatest risk of experiencing a future mental health condition. Exfoliated primary teeth, when used in combination with established and emerging tools (e.g., family history, imaging, genetics, epigenetics), may provide important additional insights about vulnerability to mental illness. Teeth are especially promising because they develop in parallel with the brain and maintain a permanent record of environmental insults occurring during prenatal and perinatal development. Despite their potential, few empirical studies have investigated features of exfoliated teeth in relation to mental health. Here, we used micro-CT imaging to test the hypothesis that measures derived from exfoliated primary incisors associated with psychopathology symptoms in a community-based sample of children (n = 37). We found that enamel volume (β = −0.77, 95% CI, −1.35 to −0.18, P = 0.01) had large negative associations with internalizing symptoms, and enamel mineral density (β = 0.77, 95% CI, 0.18–1.35, P = 0.01) had large positive associations with internalizing behavioral symptoms, even after stringent control for multiple testing. Pulp volume (β = −0.50, 95% CI, −0.90 to −0.09, P = 0.02) had a moderately-large negative association with externalizing behavioral symptoms, though these associations did not survive multiple testing correction. These results support the ongoing investigation of teeth as potential novel biomarkers of mental health risk.

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Disturbances in primary dental enamel in Polish autistic children

Cited by 3 publications

References 79 publications

Enamel histomorphometry, growth patterns and developmental trajectories of the first deciduous molar in an Italian early medieval skeletal series

Enamel histomorphometry, growth patterns and developmental trajectories of the first deciduous molar in an Italian early medieval skeletal series

Enamel incremental markings in the deciduous teeth of children from the Early Bronze and modern ages

Association Between Measures Derived From Children's Primary Exfoliated Teeth and Psychopathology Symptoms: Results From a Community-Based Study

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