Disturbance of the intestinal microbial community by ursolic acid contributes to its function as a regulator of fat deposition

Feng, Zemeng; Wu, Chunli; Zhou, Jiaogen; Wu, Fei; Li, Jun; Li, Tiejun; Yin, Yulong

doi:10.1016/j.jff.2015.02.015

Cited by 12 publications

(7 citation statements)

References 67 publications

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“…The impact of orally delivered ursolic acid on intestinal microbiota was studied by Feng et al [204]. Their results showed that it decreased the microbial diversity in the proximal intestine while having an opposite effect in the distal intestine.…”

Section: Anti-microbial Properties Of Ursolic Acidmentioning

confidence: 99%

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

2015

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Ursolic acid (UA) is a natural terpene compound exhibiting many pharmaceutical properties. In this review the current state of knowledge about the health-promoting properties of this widespread, biologically active compound, as well as information about its occurrence and biosynthesis are presented. Particular attention has been paid to the application of ursolic acid as an anti-cancer agent; it is worth noticing that clinical tests suggesting the possibility of practical use of UA have already been conducted. Amongst other pharmacological properties of UA one can mention protective effect on lungs, kidneys, liver and brain, anti-inflammatory properties, anabolic effects on skeletal muscles and the ability to suppress bone density loss leading to osteoporosis. Ursolic acid also exhibits anti-microbial features against numerous strains of bacteria, HIV and HCV viruses and Plasmodium protozoa causing malaria.

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Section: Anti-microbial Properties Of Ursolic Acidmentioning

confidence: 99%

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

2015

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“…To determine whether the improvement of the symptoms of S. aureus infection in mice is related to the structure of the intestinal flora and to study the effects of the mixed LAB on the intestinal microbiota of mice infected with S. aureus , we used Illumina high-throughput sequencing. Illumina’s MiSeq platform has been shown to be at least as good as the 454 platform and costs much less [ 15 ] .…”

Section: Introductionmentioning

confidence: 99%

Effects of mixed lactic acid bacteria on intestinal microbiota of mice infected with Staphylococcus aureus

et al. 2018

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BackgroundThe stability of intestinal microorganisms plays an important role in human health, as the intestines perform important functions in the human body. Staphylococcus aureus is a Gram-positive, facultative anaerobic bacteria, it causes human infection worldwide, and is a major pathogen that causes intestinal infection. Mixed lactic acid bacteria (LAB) may have potential in the prevention and treatment of S. aureus infection. In the present study, we examined the effects of mixed LAB treatment on intestinal microbiota modulation in mice infected with S. aureus.ResultsHigh-throughput sequencing of the V3-V4 region of the bacterial 16S rRNA gene showed that the mixed LAB maintained the richness and diversity of the microbiota in the mouse intestine. By establishing operational taxonomic units and using rarefaction analysis, rank-abundance distribution curves, heat maps, Venn diagrams, bacterial community structures, and hierarchical clustering analysis, Bacteroidales, Lachnospiraceae, Bacteroides and Prevotellaceae were the most abundant taxa in the samples, we found that the composition of the intestinal microbiota was similar between the protection group administered mixed LAB and the negative control group.ConclusionsStaphylococcus aureus destroys the stable intestinal microbiota structure of mice, treatment with mixed LAB could prevent S. aureus infection in mice and improve the structure of the intestinal microbiota.

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“…Although the underlying mechanism is not yet known, changes in microbial diversity in the intestine may potentially contribute to fat accumulation and degeneration of the liver and kidney. Some photochemicals such as ursolic acid have been reported to change the amount of gut bacteria and decrease the risk of obesity [ 11 ]. The composition of fatty acids in pet food may influence the expression of amino acids in the liver and kidney [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, there are reasons to be concerned about the raw materials used for pet food production. For example, increased oral intake of fat, monosodium L-glutamate, and ursolic acid may introduce significant alterations in the composition of gut microbiota, which are thought to play an important role in amino acid [ 10 ], and lipid metabolism [ 11 ]. The objective of this study is to determine the safety of pet foods currently available in the market, in light of the increasing incidence of chronic diseases in pets due to their food intakes.…”

Section: Introductionmentioning

confidence: 99%

Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

et al. 2016

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BackgroundThe commercial pet-food industry and the market value of the pet industry have increased. Most owners are concerned about their pets’ health, and prefer commercial pet foods as their regular diet. This study thus aimed to determine whether a selection of local generic-brand dry canine foods had any potential to promote chronic disease.MethodsFive local, generic-brand, dry canine foods were studied for potential mutagenicity; the effects of long-term consumption were also observed in rats. All canine foods were extracted with distilled water and absolute ethanol. The Ames test was used to detect short-term genetic damage, using Salmonella typhimurium tester strains TA98 and TA100. Simultaneously, the long-term effects were studied in an animal model by observing rats fed with these canine foods, compared with normal rat food, for a period of 15 weeks.ResultsUsing the water extracts, all dry canine foods studied showed considerable mutagenic effects on the tester strains. One brand affected both tester strains, whereas 3 showed positive to TA98, and one to TA100. With the absolute ethanol extract, three of the five brands had a considerable mutagenic effect on TA98, and another affected TA100. In the long-term test, all rats remained alive until the end of the experiment, exhibited no apparent signs of toxicity or serious illness, and maintained normal bodyweight and weight gain. Serum blood biochemistry and hematological parameters in canine food-fed rats showed some negative effects. Correspondingly, histopathological investigation of their liver and kidneys showed deterioration.ConclusionsMutagenic potential and the negative potential health impacts were observed in all local-brand dry canine foods tested.

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Disturbance of the intestinal microbial community by ursolic acid contributes to its function as a regulator of fat deposition

Cited by 12 publications

References 67 publications

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

Ursolic Acid—A Pentacyclic Triterpenoid with a Wide Spectrum of Pharmacological Activities

Effects of mixed lactic acid bacteria on intestinal microbiota of mice infected with Staphylococcus aureus

Thai generic-brand dry canine foods: mutagenicity and the effects of feeding in vivo and in vitro

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