Distributions and Types of Multidrug-Resistant Acinetobacter baumannii in Different Departments of a General Hospital

Qian, Yaner; Dong, Xuejun; Zong-xin, Wang; Yang, Guanpin; Liu, Qi

doi:10.5812/jjm.22935

Cited by 10 publications

(7 citation statements)

References 18 publications

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“…A study conducted in Pakistan also found that the ST2 clone-harboring bla NDM-1 and bla OXA-23 , which are widely distributed in ICUs, could prompt increased mortality ( Ejaz et al, 2021 ). Notably, a study in another Chinese hospital in Shanghai reported the presence of bla OXA-23 in all CRAB strains ( Wang et al, 2021 ), and it was found that the predominant clone of CRAB was ST208, which was consistent with the results obtained by Qian et al (2015) .…”

Section: Drug Resistance Mechanism and Homology Of Crab Isolated From...supporting

confidence: 82%

Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit

et al. 2022

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Carbapenem-resistant Acinetobacter baumannii (CRAB) has become one of the leading causes of healthcare-associated infections globally, particularly in intensive care units (ICUs). Cross-transmission of microorganisms between patients and the hospital environment may play a crucial role in ICU-acquired CRAB colonization and infection. The control and treatment of CRAB infection in ICUs have been recognized as a global challenge because of its multiple-drug resistance. The main concern is that CRAB infections can be disastrous for ICU patients if currently existing limited therapeutic alternatives fail in the future. Therefore, the colonization, infection, transmission, and resistance mechanisms of CRAB in ICUs need to be systematically studied. To provide a basis for prevention and control countermeasures for CRAB infection in ICUs, we present an overview of research on CRAB in ICUs, summarize clinical infections and environmental reservoirs, discuss the drug resistance mechanism and homology of CRAB in ICUs, and evaluate contemporary treatment and control strategies.

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Section: Drug Resistance Mechanism and Homology Of Crab Isolated From...supporting

confidence: 82%

Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit

et al. 2022

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“…15 Moreover, at the same hospital but in different wards, the distribution of clones and mechanism of resistance also varied in different clinical departments. 16 Thus, our study, performed in a private hospital, revealed the same bla OXA23 as related studies but reported two patients carrying two carbapenemase genes (bla OXA23 and bla NDM1 ) simultaneously.…”

Section: Discussionsupporting

confidence: 76%

Identification of blaOXA23 and blaNDM1 from Carbapenem- resistant Acinetobacter baumannii at a Private Hospital in Thailand

Leelasupasri¹,

Santimaleeworagun²,

Jitwasinkul³

2019

bkkmedj

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A cinetobacter baumannii, a Gram-negative coccobacilli, is a major causative pathogen involving nosocomial infection in various organs, such as the lower respiratory tract, skin/soft tissue, blood and, rarely, in the urinary tract and central nervous system. 1 In Thailand, regarding the data of the first half-year of 2018, 2 A. baumannii was the third and second ranked organism isolated from all specimens and sputum, respectively. This pathogen is not only an important nosocomial pathogen, but also has multiple mechanisms to resist the current antimicrobials varied from multi-drug treatment (more than three groups), extensive drug resistance (resistant to all antibiotics except colistin and tigecycline) to pan-drug (resistant to all available antibiotics). 3 Over the past 19 years (from 2000-2018), the prevalence of carbepenem resistant A. baumannii (CRAB) has increased. 2 The National Antimicrobial Resistance Surveillance, Thailand (NARST) reported that among A. baumannii isolates from hospitalized patients in 50 hospitals, the rate of CRAB increased from 5.8% in 2000 to 52.5% in 2018. 2 However, the increasing rate of CRAB has affected carbapenems use as empirical therapy for infections suspected of A. baumannii. The known type of carbapenemase enzyme in CRAB remains important for some circumstances including the role of carbapenems in combination with the other antimicrobials against CRAB and the upcoming use of new betalactamase inhibitor such as avibactam against carbapenemase producing organisms. 4,5 To date, carbapenem-destroying enzymes in CRAB have been found in two major types, namely, OXA-carbapenemases and metallo-beta lactamases. 1

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“…19 In the present study, 80 A. baumannii isolates were collected from the diagnostic laboratory of a burn hospital which is very high considering the duration of the research period (two months) compared to similar studies in other hospitals. 20,21 Since this level of infection was found in hospitals during a two-month period, further investigation is needed to determine whether there is a problem with cross-transmission, either within the hospital in question and/or other hospitals from which patients are received into this hospital. Our hospital is the major burn center and many burn patients from other hospitals are hospitalised in the ICU of the targeted hospital; in addition, many clinical samples are transferred from other hospitals to this one for the culturing and confirmation of bacterial identification.…”

Section: Discussionmentioning

confidence: 99%

Molecular identification and genotyping of Acinetobacter baumannii isolated from burn patients by PCR and ERIC-PCR

Falah

Shokoohizadeh

Adabi

2019

Scars, Burns & Healing

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Background: Acinetobacter baumannii is one of the most important agents of hospital infections. Rapid and accurate identification and genotyping of A. baumannii is very important, especially in burn hospitals in order to prevent the spread of related nosocomial infections and to further epidemiological studies. Material and methods: For two months, 82 A. baumannii isolates were collected from burn wound swabs of patients in a major burn hospital in Tehran. A. baumannii isolates were identified by conventional microbiological test and polymerase chain reaction (PCR) using the primers of blaOXA-51 gene, while the genetic linkage of A. baumannii isolates was investigated by enterobacterial repetitive intragenic consensus (ERIC)-PCR technique. Similarity, a cut-off of ⩾ 95% was considered for classifying the genotypes. Results: The molecular test (PCR) confirmed 97.56% of phenotypic results for the detection of A. baumannii isolates. ERIC-PCR results revealed 14 different ERIC patterns (ERIC-types) including 11 common types and three unique types. Conclusion: Our findings show that we can simply and quickly detect A. baumannii isolates by PCR using blaOXA genes and genetic diversity by ERIC-PCR, respectively. These rapid and simple techniques for the routine screening and identification of clinical A. baumannii isolates could be useful with epidemic potential.

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Distributions and Types of Multidrug-Resistant Acinetobacter baumannii in Different Departments of a General Hospital

Cited by 10 publications

References 18 publications

Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit

Carbapenem-resistant Acinetobacter baumannii: A challenge in the intensive care unit

Identification of blaOXA23 and blaNDM1 from Carbapenem- resistant Acinetobacter baumannii at a Private Hospital in Thailand

Molecular identification and genotyping of Acinetobacter baumannii isolated from burn patients by PCR and ERIC-PCR

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