Distribution, Teratogenicity, and Embryonic Delivered Dose of Retinoid Ro 23-9223

Willhite, Calvin C.; Lovey, Allen; Eckhoff, Christian

doi:10.1006/taap.1999.8866

Cited by 6 publications

(2 citation statements)

References 22 publications

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“…In human beings, isotretinoin is associated with a wide spectrum of birth defects, including craniofacial, heart, and nervous system malformations. Reported effects have included agenesis of the cerebellar vermis; malformation of posterior fossa; multiple leptomeningeal neuroglial heterotopias; hydrocephalus; abnormalities of the corticospinal tracts; mid-hindbrain malformations; craniofacial defects including anotia and microtia; abnormalities of the inner ear; ocular, retinal, or optic nerve abnormalities, including myopia and light sensitivity; psychomotor retardation; mental retardation; learning disabilities; and premature birth 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35…”

Section: Methodsmentioning

confidence: 99%

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Suuberg¹

2019

Current Therapeutic Research

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Highlights Isotretinoin teratogenicity well established; psychiatric effects documented, controversial Disturbed retinoid signaling implicated in isotretinoin teratogenic and psychiatric effects Effect of genetics on susceptibility to psychiatric side effects is possible, not yet known Postnatal neurocognitive effects of isotretinoin not yet established

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Section: Methodsmentioning

confidence: 99%

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Suuberg¹

2019

Current Therapeutic Research

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“…Reported effects have included agenesis of the cerebellar vermis; malformation of posterior fossa; multiple leptomeningeal neuroglial heterotopias; hydrocephalus; abnormalities of the corticospinal tracts; mid-hindbrain malformations; craniofacial defects including anotia and microtia; abnormalities of the inner ear; ocular, retinal, or optic nerve abnormalities, including myopia and light sensitivity; psychomotor retardation; mental retardation; learning disabilities; and premature birth. [25][26][27][28][29][30][31][32][33][34][35] Isotretinoin is thought to induce cleft palate in human beings by sustaining the expression of epidermal growth factor receptors in medial epithelial cells of the palate at a time when these cells would normally undergo apoptosis, resulting in continued DNA synthesis, proliferation, survival, and shift in cell phenotype. 36 In nonhuman primate models, isotretinoin has produced defects of the cerebellar vermis by interfering with processes that subdivide the cerebellum into smaller units; craniofacial skeleton and heart defects due to exposure earlier during gestation; and thymus and cerebellum defects due to exposure later during gestation, with defect severity generally depending on duration of exposure.…”

Section: Teratogenic Effectsmentioning

confidence: 99%

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Suuberg¹

2018

SSRN Journal

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Background: An association between isotretinoin (13-cis-retinoic acid, sold under trade names including Accutane [Hoffmann-La Roche Inc, Basel, Switzerland]) and birth defects, depression, and suicide is well documented but controversial. A link to psychosis and exacerbation of bipolar symptoms is less extensively addressed in the literature. Objective: Given recent conceptualization of psychotic disorders as neurodevelopmental, and current interest in possible shared etiology of different neurodevelopmental disorders such as psychosis, autism, and intellectual disability, this review concurrently examines the literature on developmental (primarily teratogenic) and psychiatric side effects of isotretinoin exposure. The goal of concurrent review is to identify shared mechanisms in the literature that may inform future effort s to clarify the neurocognitive and psychiatric effects of isotretinoin exposure at different developmental stages or given different genetic backgrounds. Methods: Literature was obtained by PubMed search for the term isotretinoin in combination with each of the terms psychosis , psychiatric , and teratogenic . Resulting articles met inclusion criteria for review if they addressed psychiatric side effects of isotretinoin treatment or the neurobehavioral teratology of isotretinoin. Results: The association of isotretinoin exposure with prenatal developmental toxicity is well established. Although numerous reports also link isotretinoin treatment with psychiatric side effects, this association remains controversial. Conclusions:The extent to which isotretinoin influences pediatric and adult development and cognition, and whether and why certain individuals may be susceptible to psychiatric side effects, remains to be clarified.

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Nuclear retinoid receptors and pregnancy: placental transfer, functions, and pharmacological aspects

Rouzaire

Belville

Bouvier

et al. 2016

Cell. Mol. Life Sci.

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Animal models of vitamin A (retinol) deficiency have highlighted its crucial role in reproduction and placentation, whereas an excess of retinoids (structurally or functionally related entities) can cause toxic and teratogenic effects in the embryo and foetus, especially in the first trimester of human pregnancy. Knock-out experimental strategies-targeting retinoid nuclear receptors RARs and RXRs have confirmed that the effects of vitamin A are mediated by retinoic acid (especially all-trans retinoic acid) and that this vitamin is essential for the developmental process. All these data show that the vitamin A pathway and metabolism are as important for the well-being of the foetus, as they are for that of the adult. Accordingly, during this last decade, extensive research on retinoid metabolism has yielded detailed knowledge on all the actors in this pathway, spurring the development of antagonists and agonists for therapeutic and research applications. Natural and synthetic retinoids are currently used in clinical practice, most often on the skin for the treatment of acne, and as anti-oncogenic agents in acute promyelocytic leukaemia. However, because of the toxicity and teratogenicity of retinoids during pregnancy, their pharmacological use needs a sound knowledge of their metabolism, molecular aspects, placental transfer, and action.

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Distribution, Teratogenicity, and Embryonic Delivered Dose of Retinoid Ro 23-9223

Cited by 6 publications

References 22 publications

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Psychiatric and Developmental Effects of Isotretinoin (Retinoid) Treatment for Acne Vulgaris

Nuclear retinoid receptors and pregnancy: placental transfer, functions, and pharmacological aspects

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