Urban dust has been contaminated with toxic heavy metals from various diffused sources. On August 28, 2019, the compact fluorescence lamp (CFL) factory that generates light for Rang Dong Light Source and Vacuum Flask in Hanoi City in Vietnam was accidentally fired. The assessment for Hg contamination and its human health impact 2 months after the incident was conducted in autumn 2019. The heavy Hg pollution is still found near CFL. Additionally, localized Hg pollution by air and wind direction was identified at sites in the northeast direction from CFL. Namely, in the area located downstream of the southwest monsoon wind, Hg had a trend higher than other directions. The hazard quotient (HQ) and the hazard index (HI) were evaluated by four routes of Hg exposure pathways. The HI values for children and adults in the most polluted site (Site 15) were 0.968 and 0.468, respectively. This meant that children who lived around this site and commuted to schools were the most at risk regarding the potential adverse health effects of Hg in street dust around the polluted areas. This study also showed that Hg levels were affected by wind direction and that the higher Hg levels in the most polluted sites resulted from the wind flow to the sites. This study revealed that street dust may be a useful tool for the assessment of human and environmental health. K E Y W O R D S children, hazard index, hazard quotient, mercury, street dust 1 | INTRODUCTION Recently, dust pollution poses a big problem in urban areas because of traffic vehicles and factories scattered around the city (Dytłow & G orka-Kostrubiec, 2021). The two primary sources of street dust are deposition of previously suspended particles (atmospheric aerosol) and displaced urban soil. This street dust can carry pollutants, including harmful heavy metals such as cadmium (Cd), mercury (Hg), lead (Pb), zinc (Zn), and other metals (Hwang et al., 2016) and affect both the urban environmental quality and human health. Several studies showed that these heavy metals were found in urban street dust at different levels (Aguilera Othman & Latif, 2020;Zhang et al., 2014). The street dust can pose potential health effects of metals upon exposure through inhalation, ingestion, and dermal contact. Residents easily come into contact with street dusts, and children are the most affected due to the hand-to-mouth activities (Zheng et al., 2010).Meanwhile, Hg is a ubiquitous environmental toxicant that can cause various adverse health effects in humans, especially children (Meza-Figueroa et al., 2007).