Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis

Liu, Rongxiu; Song, Guixue; Wu, Peigen; Zhang, Xuewen; Hu, Huijuan; Liu, Jia; Miao, Xiao-Su; Hou, Zhiyan; Wang, Wenquan; Wei, Shengli

doi:10.1016/s1875-5364(17)30030-4

Cited by 12 publications

(6 citation statements)

References 27 publications

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“…With the wide application of neuroprotective strategies in neurological disease (Szwajgier et al, 2017; Mendes et al, 2019), traditional Chinese medicine has attracted increasing attention due to its advantages of easy penetration of blood–brain barrier and abundance in nature (Zeng, 2017; Chen and Lin, 2018). Baicalein (5,6,7-trihydroxyflavone) is a type of flavonoid compound, which can be acquired from the roots of Scutellaria baicalensis , has possessed remarkable neuroprotective effects in neurological diseases, such as AD and PD (Li et al, 2011; Gao et al, 2015; Gu et al, 2016; Zhou et al, 2016; Dinda et al, 2017; Liu et al, 2017). In addition, it has recently been reported that baicalein could exert significant neuroprotective effects in the treatment of temporal lobe epilepsy by reducing oxidative stress and inflammation (Qian et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

Jia

et al. 2019

Front. Pharmacol.

115

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Posttraumatic epilepsy (PTE) is a prevalent type of acquired epilepsy secondary to traumatic brain injury, and is characterized by repeated seizures. Traditional antiepileptic drugs have minimal response in preventing posttraumatic epileptic seizures. It is essential for the development of new therapeutic strategy. Our previous work disclosed a potent neuroprotective role of baicalein, a flavonoid extracted from Scutellaria baicalensis Georgi, against inherited epilepsy in rats. Whether baicalein has protective potential in posttraumatic epileptic seizures and the possible molecular mechanism remain elusive. Additionally, the brain is vulnerable to lipid peroxidation-induced damage due to high consumption of oxygen and abundant polyunsaturated fatty acids in neuronal membranes. Our present investigation aimed to elucidate whether baicalein exerts neuroprotective effects on posttraumatic epileptic seizures by inhibiting ferroptosis, a newly discovered lipid peroxidation-dependent cell death modality. We found that baicalein significantly reduced seizure score, number of seizures, and average seizure duration in an iron chloride (FeCl 3 )-induced PTE mouse model. The neuroprotective effect of baicalein was also validated in a ferric ammonium citrate (FAC)-induced HT22 hippocampal neuron damage model. Moreover, in vitro , baicalein could remarkably decrease ferroptotic indices (lipid reactive oxygen species, 4-hydroxynonenal, and prostaglandin endoperoxide synthase 2) and inhibit the expression of 12/15-lipoxygenase (12/15-LOX) in an iron-induced HT22 cell damage model. These findings were also validated in a mouse PTE model. It was concluded that baicalein exerted neuroprotective effects against posttraumatic epileptic seizures via suppressing ferroptosis and 12/15-LOX was likely to be involved in baicalein’s neuroprotection.

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Section: Discussionmentioning

confidence: 99%

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

Jia

et al. 2019

Front. Pharmacol.

115

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“…Scutellaria baicalensis Georgi is an important medicinal plant in the Lamiaceae family and is extensively used in China, Japan, and Southeast Asian countries [ 39 ]. Scutellariae Radix (the dried root of S. baicalensis ) has been applied as an ethnobotanical herbs for more than 2000 years, since being recorded in Chinese ancient medical books [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Systematic Analysis and Functional Characterization of R2R3-MYB Genes in Scutellaria baicalensis Georgi

Wang

Zhang

et al. 2022

IJMS

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R2R3-MYB transcription factors participate in multiple critical biological processes, particularly as relates to the regulation of secondary metabolites. The dried root of Scutellaria baicalensis Georgi is a traditional Chinese medicine and possesses various bioactive attributes including anti-inflammation, anti-HIV, and anti-COVID-19 properties due to its flavonoids. In the current study, a total of 95 R2R3-MYB genes were identified in S. baicalensis and classified into 34 subgroups, as supported by similar exon–intron structures and conserved motifs. Among them, 93 R2R3-SbMYBs were mapped onto nine chromosomes. Collinear analysis revealed that segmental duplications were primarily responsible for driving the evolution and expansion of the R2R3-SbMYB gene family. Synteny analyses showed that the ortholog numbers of the R2R3-MYB genes between S. baicalensis and other dicotyledons had a higher proportion compared to that which is found from the monocotyledons. RNA-seq data indicated that the expression patterns of R2R3-SbMYBs in different tissues were different. Quantitative reverse transcriptase-PCR (qRT-PCR) analysis showed that 36 R2R3-SbMYBs from different subgroups exhibited specific expression profiles under various conditions, including hormone stimuli treatments (methyl jasmonate and abscisic acid) and abiotic stresses (drought and cold shock treatments). Further investigation revealed that SbMYB18/32/46/60/70/74 localized in the nucleus, and SbMYB18/32/60/70 possessed transcriptional activation activity, implying their potential roles in the regulatory mechanisms of various biological processes. This study provides a comprehensive understanding of the R2R3-SbMYBs gene family and lays the foundation for further investigation of their biological function.

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“…As a Chinese traditional medicine, Huang qin usually refers to the dried root of Scutellaria baicalensis Georgi. Modern pharmacokinetic studies have confirmed that baicalein (5, 6, 7-trihydroxyflavone) is a major bioactive flavone constituent of Scutellaria baicalensis Georgi (Liu et al, 2017). Baicalein has been well known for its broad pharmacological activities, including antibacterial, antiviral, anticarcinogenic and anti-inflammatory activities in TCM (Dinda et al, 2017;Huang et al, 2005;Ji et al, 2015;Li et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease

Zhao

Hölscher

2017

CNS Drugs

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Alzheimer's disease and Parkinson's disease are the two most common, progressive central neurodegenerative diseases affecting the population over the age of 60 years. Apart from treatments that temporarily improve symptoms, there is no medicine currently available to inhibit or reverse the progression of Alzheimer's disease and Parkinson's disease. In traditional Chinese medicine, the root of Scutellaria baicalensis Georgi is a classic compatible component in the decoction of herbal medicine used for treating central nervous system diseases. Modern pharmacokinetic studies have confirmed that baicalein (5,6,7-trihydroxyflavone) is a major bioactive flavone constituent root of S. baicalensis Georgi. Studies showed that baicalein possesses a range of key pharmacological properties, such as reducing oxidative stress, anti-inflammatory properties, inhibiting aggregation of disease-specific amyloid proteins, inhibiting excitotoxicity, stimulating neurogenesis and differentiation action, and anti-apoptosis effects. Based on these properties, baicalein shows therapeutic potential for Alzheimer's disease and Parkinson's disease. In this review, we summarize the pharmacological protective actions of baicalein that make it suitable for the treatment of Alzheimer's disease and Parkinson's disease, and discuss the potential mechanisms underlying the effects.

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Distribution patterns of the contents of five biologically activate ingredients in the root of Scutellaria baicalensis

Cited by 12 publications

References 27 publications

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

Systematic Analysis and Functional Characterization of R2R3-MYB Genes in Scutellaria baicalensis Georgi

Therapeutic Potential of Baicalein in Alzheimer’s Disease and Parkinson’s Disease

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