Distribution patterns of intramyocellular and extramyocellular fat by magnetic resonance imaging in subjects with diabetes, prediabetes and normoglycaemic controls

Kiefer, Lena S.; Jaña, Fabián; Rospleszcz, Susanne; Lorbeer, Roberto; Machann, Jürgen; Kraus, M.; Roemer, Frank W.; Rathmann, Wolfgang; Meisinger, Christa; Heier, Margit; Nikolaou, Konstantin; Peters, Annette; Storz, Corinna; Diallo, Thierno D.; Schlett, Christopher L.; Bamberg, Fabian

doi:10.1111/dom.14413

Cited by 20 publications

(15 citation statements)

References 25 publications

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“…Myosteatosis is an ectopic fat bank that increases with age. Lipid deposition in skeletal muscle leads to the accumulation of lipid intermediates (diacylglycerol and ceramide) and destroys the insulin signaling pathway, leading to insulin resistance (IR) and the development of type 2 diabetes ( 48 , 50 , 51 ). In addition, researchers have found that there is a positive correlation between abdominal adipose tissue and the homeostasis model assessment of insulin resistance (HOMA-IR) in elderly white men without diabetes ( 52 ) and a negative correlation with insulin sensitivity ( 53 ).…”

Section: Discussionmentioning

confidence: 99%

The Impact and Clinical Prediction of Hyperglycemia During Parenteral Nutrition for Nondiabetic Patients After Gastrectomy for Gastric Cancer

et al. 2022

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Background and PurposeHyperglycemia (HG) is associated with increased postoperative complications. This study aims to evaluate the effect of HG during supplemental parenteral nutrition (SPN) on short-term prognosis in non-diabetic patients undergoing gastrectomy for cancer and to analyse the risk factors and prevention methods for HG.MethodsA total of 359 patients were divided into three groups according to blood glucose (BG) during SPN: normoglycemic patients ( ≤ 125 mg/dL), mild HG (125~200 mg/dL), and severe HG (>200 mg/dL). The effect of BG on postoperative short-term outcomes was analyzed. Multivariate regression was performed to investigate influencing factors for severe HG. The safety and efficacy of insulin addition to total nutrient admixture (TNA) for the prevention and management of HG were assessed by propensity score matching (PSM). In addition, regression analysis was performed in the noninsulin group to investigate the predictive factors of severe HG, and a nomogram was plotted.ResultsThe postoperative complication rate was 18.9%, but it was significantly higher in patients with severe HG than in mild HG and normoglycemic patients (25.2, 15.0, and 10.0%, respectively, p < 0.05). Multivariate logistic regression analysis showed that anemia, myosteatosis, higher postoperative capillary blood glucose (CBG) before TNA infusion, and insulin in the TNA were independent influencing factors for severe HG. Based on the above factors, 75 pairs of patients (insulin group and non-insulin group) with comparable baseline data were successfully matched by PSM. The HG incidence and the glycemic fluctuation were significantly improved through 1 U insulin/6 g glucose (1/6 scheme) to TNA. A nomogram containing hemoglobin, skeletal muscle radiodensity, pre-SPN CBG, and pTNM stage with good predictive efficacy (C-index: 0.750) was constructed based on the noninsulin group.ConclusionPoor postoperative glycemic control was related to worse outcomes in non-diabetic patients undergoing gastrectomy for cancer. Pre-operative anemia, myosteatosis, and high postoperative CBG before TNA infusion are risk factors for severe HG. Insulin in TNA can improve the blood glucose control of patients. Our proposed nomogram rendered an individualized predictive tool for HG during SPN, which helps screen high-risk patients requiring insulin therapy. Future studies with larger samples are needed to develop a complete insulin application protocol for SPN.

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Section: Discussionmentioning

confidence: 99%

The Impact and Clinical Prediction of Hyperglycemia During Parenteral Nutrition for Nondiabetic Patients After Gastrectomy for Gastric Cancer

et al. 2022

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“…In terms of improving systemic glucose metabolism, consistent with previous studies, we found that gAd significantly reduced blood glucose levels and improved impaired glucose tolerance in high-fat diet mice, which is in agreement with the improvement of glucose metabolism by aerobic exercise. 37 , 38 Additionally, muscle lipid deposition is considered to be an important determinant of insulin resistance in skeletal muscle, 39 , 40 since increases in intramyocellular lipid and intermyocellular adipose tissue are associated with impaired skeletal muscle insulin signaling. Our study found that either exercise or gAd intervention reduced lipid ectopic deposition in the quadriceps muscle of mice and that SESN2 was involved.…”

Section: Discussionmentioning

confidence: 99%

Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2

Liu

Yang²,

Shao³

et al. 2023

Sports Medicine and Health Science

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“…The sample size for our pilot study was set according to that in previous studies that used an exploratory case study of fat distribution among older adults [ 30 , 31 ]. The exclusion criteria were: diseases that affect fat distribution and/or physical performance [ 32 , 33 , 34 ]; a clinical history of diabetes mellitus, heart disease (myocardial infarction, congestive heart failure, and angina pectoris), cerebrovascular disease (stroke, cerebral infarction, and cerebral hemorrhage), Parkinson’s disease, or previous hip and knee replacements; and patients with contraindications for magnetic resonance imaging (MRI). The participants underwent dual-energy X-ray absorptiometry (DXA), MRI, and 1 H-MRS to assess their body fat distribution and body composition.…”

Section: Methodsmentioning

confidence: 99%

Sex-Specific Differences in Lower Body Fat Distribution and Association with Physical Performance among Healthy Community-Dwelling Older Adults: A Pilot Study

Kim

Won

2022

IJERPH

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This study aims to examine sex-specific differences in body composition and lower extremity fat distribution and their association with physical performance among healthy older adults. The pilot study comprises 40 subjects (20 men and 20 women) matched by age and body mass index. The participants undergo dual-energy X-ray absorptiometry, magnetic resonance imaging, and proton magnetic resonance spectroscopy (1H-MRS) to assess body composition and lower extremity fat distribution. 1H-MRS is used to measure the extramyocellular lipid (EMCL) and intramyocellular lipid (IMCL) contents of the lower leg muscles (soleus and tibialis anterior) at the maximum circumference of the calf after overnight fasting. The tibialis anterior IMCL, as assessed by 1H-MRS, is negatively associated with the five-times sit-to-stand test scores (rs = 0.518, p = 0.023) in men, while the soleus IMCL content is negatively associated with the timed up-and-go test scores (rs = 0.472, p = 0.048) in women. However, the soleus EMCL content is positively associated with the five-times sit-to-stand test scores (rs = −0.488, p = 0.040) in women, but this association is not statistically significant in men. This study shows an inverse correlation between IMCL content and physical performance in healthy older individuals and lower leg muscle-specific IMCL based on sex differences. Furthermore, our results suggest that greater EMCL content in the soleus and calf subcutaneous fat might affect physical performance positively in women but not men.

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Distribution patterns of intramyocellular and extramyocellular fat by magnetic resonance imaging in subjects with diabetes, prediabetes and normoglycaemic controls

Cited by 20 publications

References 25 publications

The Impact and Clinical Prediction of Hyperglycemia During Parenteral Nutrition for Nondiabetic Patients After Gastrectomy for Gastric Cancer

The Impact and Clinical Prediction of Hyperglycemia During Parenteral Nutrition for Nondiabetic Patients After Gastrectomy for Gastric Cancer

Globular adiponectin ameliorates insulin resistance in skeletal muscle by enhancing the LKB1-mediated AMPK activation via SESN2

Sex-Specific Differences in Lower Body Fat Distribution and Association with Physical Performance among Healthy Community-Dwelling Older Adults: A Pilot Study

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