Distribution of β-lactamases and emergence of carbapenemases co-occurring Enterobacterales isolates with high-level antibiotic resistance identified from patients with intra-abdominal infection in the Asia–Pacific region, 2015–2018

Chen, Yu-Chin; Chen, Wei-Yu; Hsu, Wei-Yun; Tang, Hung‐Jen; Chou, Yun; Chang, Yin‐Cheng; Chen, Chi‐Chung; Chuang, Yin-Ching; Chang, Tu‐Hsuan

doi:10.1016/j.jmii.2021.07.007

Cited by 12 publications

(7 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Within the carbapenem-resistance genes, OXA-1 was found to be co-occurring with NDM class genes with a co-resistance rate of >83%. This is correlated with a study conducted in Dubai, UAE, showing a similar pattern of resistance 32 . This study is important, especially for clinicians, because it would help them dispense antibiotics to which the bacteria are susceptible.…”

Section: Discussionsupporting

confidence: 90%

Genomic analysis of Carbapenem-resistance conferring genes in Klebsiella pneumoniae

Subramanian¹

2023

Preprint

View full text Add to dashboard Cite

Carbapenems are considered for treating Klebsiella pneumoniae and other Enterobacteriaceae infections, especially if they are not susceptible to other generally prescribed antibiotics, i.e., if they show resistance. In such cases, antibiotic activity decreases, and most patients succumb to the infection. A better understanding of the disease pattern and resistance mechanisms could be gained by magnifying the genes that confer resistance to antibiotics. Therefore, studying the genes that confer resistance to carbapenems and any other antibiotics for that matter is indispensable for coming up with improved treatment options. This study included the analyses of co-resistance patterns between resistance genes-between drug classes and within the carbapenem-resistant genes, genomic context analysis of highly expressed carbapenem-resistant genes, and phylogenetic study of OXA-producing genes, plasmid incompatibility identification, and sequence type identification using MLST. The presence of ESBLs, MBLs, and SBLs across the downloaded genomes was studied. SHV-producing genes were found to co-occur with most of the resistant genes belonging to different drug classes. The plasmid incompatibility type IncFIB was found to be common among the highly expressed genes, and most of these genes were flanked by different families of insertion sequence (IS) elements. MLST study suggested that the presence of sequence types ST-11, ST-14, and ST-147 was common in the downloaded set of genomes.

show abstract

Section: Discussionsupporting

confidence: 90%

Genomic analysis of Carbapenem-resistance conferring genes in Klebsiella pneumoniae

Subramanian¹

2023

Preprint

View full text Add to dashboard Cite

show abstract

“… 29 , 30 In previous work, we found that the TEM, CTX-M-15, and CMY-2 β-lactamases were the most commonly identified among our piperacillin/tazobactam-resistant E. coli isolates. 25 Although we could not measure their enzyme activity in our study, these isolates are known to potentially express substantial amounts of β-lactamase, which could explain their resistance to piperacillin/tazobactam.…”

Section: Discussionmentioning

confidence: 89%

“… 27 , 28 Previous SMART surveillance data have shown that the co-occurrence of plasmid-mediated AmpC beta-lactamase/ESBLs among carbapenemase-negative E. coli is common in Taiwan and Vietnam. 25 The in vitro antimicrobial susceptibility rates to cefepime in these isolates are low, with rates as low as 19.6%. While this finding may partially explain the observed low in vitro susceptibility rates to cefepime, further examination is needed to confirm this hypothesis.…”

Section: Discussionmentioning

confidence: 96%

“… 23 , 24 Our previous work identified CTX-M-1 (CTX-M-15, CTX-M-55) and CTX-M-9 (CTX-M-14, CTX-M-27) as the major groups of ESBLs between 2015 and 2018 in the Asia-Pacific region. 25 ST131 is considered the most prevalent and clinically important sequence type associated with CTX-M ESBLs. 26 These findings may partly explain the increasing ceftriaxone resistance observed in the Asia-Pacific region, considering the widespread prevalence of ESBLs among E. coli isolates.…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of carbapenemase-producing genes has remained stable in previous SMART surveillance, indicating that dissemination of carbapenemase-producing clones is an unlikely explanation for this trend. 25 Recent studies suggest that hyperproduction of SHV and TEM-1 β-lactamases may contribute to β-lactam/β-lactamase inhibitor resistance in E. coli . 29 , 30 In previous work, we found that the TEM, CTX-M-15, and CMY-2 β-lactamases were the most commonly identified among our piperacillin/tazobactam-resistant E. coli isolates.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Antimicrobial Susceptibility of E. coli Isolates from Intra-Abdominal Infections in the Asia-Pacific Region: Trends in Ciprofloxacin, Ceftriaxone, Cefepime, and Piperacillin/Tazobactam Susceptibility

Tsai,

Chen,

Chen

et al. 2023

IDR

Self Cite

View full text Add to dashboard Cite

Purpose To investigate the antibiotic susceptibility of Escherichia coli isolates in patients diagnosed with intra-abdominal infections (IAIs) in the Asia-Pacific region. Patients and Methods This study was conducted at 50 medical hospitals across 9 countries/regions as part of the Study for Monitoring Antimicrobial Resistance Trends (SMART) surveillance program from 2014 to 2018. Nonduplicate isolates of aerobic and facultative gram-negative bacilli were collected and processed for further antimicrobial susceptibility testing. Results A total of 10,709 isolates were collected, with E. coli (n=4737, 44.2%) being the leading pathogen causing IAIs, followed by Klebsiella pneumoniae (n=2429, 22.7%) and Pseudomonas aeruginosa (n=931, 8.7%). Community-associated (CA) E. coli isolates generally exhibited higher susceptibility rates for most antibiotics than hospital-associated (HA) isolates. In countries/regions other than Hong Kong, South Korea, and Singapore, HA isolates displayed lower susceptibility rates for multiple classes (≥4) of antibiotics. Among the commonly used antibiotics in IAIs, the overall susceptibility rate for ciprofloxacin was low, with an average of 41.3%. Ceftriaxone susceptibility rates in all selected countries were below 80% starting in 2018, ranging from 23.3% to 75.8%. The cefepime susceptibility rates varied across regions, with consistently reduced susceptibility ranging from 45.5% to 57.8% in India, Thailand, and Vietnam. Piperacillin/tazobactam demonstrated effectiveness against E. coli isolates in almost all countries except India, with a downward trend observed in the Philippines and Taiwan. Carbapenems remained effective against more than 90% of E. coli isolates, except in India. Conclusion Prudent use of fluoroquinolones and ceftriaxone is advised when treating both CA and HA IAIs in the Asia-Pacific region. The low susceptibility rate of cefepime in India, Thailand, and Vietnam needs careful consideration in its administration. Moreover, the increase in nonsusceptibility to piperacillin/tazobactam in the Philippines and Taiwan poses a potential risk that should be closely monitored.

show abstract

Geographical patterns of in vitro susceptibilities to tigecycline and colistin among worldwide isolates of Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme, 2016–2021

Wang

Lai

et al. 2023

International Journal of Antimicrobial Agents

View full text Add to dashboard Cite

Distribution of β-lactamases and emergence of carbapenemases co-occurring Enterobacterales isolates with high-level antibiotic resistance identified from patients with intra-abdominal infection in the Asia–Pacific region, 2015–2018

Cited by 12 publications

References 34 publications

Genomic analysis of Carbapenem-resistance conferring genes in <i>Klebsiella</i><i> </i><i>pneumoniae</i>

Genomic analysis of Carbapenem-resistance conferring genes in <i>Klebsiella</i><i> </i><i>pneumoniae</i>

Antimicrobial Susceptibility of E. coli Isolates from Intra-Abdominal Infections in the Asia-Pacific Region: Trends in Ciprofloxacin, Ceftriaxone, Cefepime, and Piperacillin/Tazobactam Susceptibility

Geographical patterns of in vitro susceptibilities to tigecycline and colistin among worldwide isolates of Acinetobacter baumannii, Escherichia coli and Klebsiella pneumoniae: Data from the Antimicrobial Testing Leadership and Surveillance (ATLAS) programme, 2016–2021

Contact Info

Product

Resources

About