Distribution of vitamin K2 in subchondral bone in osteoarthritic knee joints

Ishii, Yoshinori; Noguchi, Hideo; Takeda, Mitsuhiro; Sato, Junko; Yamamoto, Noriaki; Wakabayashi, Hiroyuki; Kanda, Junkichi; Toyabe, Shin-ichi

doi:10.1007/s00167-012-2239-4

Cited by 5 publications

(6 citation statements)

References 34 publications

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“…Our results showing a relation between GRP and MGP ␥-carboxylation deficiency and OA are also in agreement with recent findings, suggesting that vitamin K metabolism may be associated with synovitis in OA patients, and that serum undercarboxylated OC could be a biomarker for OA [38]. The novel association of both phylloquinone (vitamin K1) and menaquinone (vitamin K2) deficiency with the disease further suggests the use of vitamin K as a potential therapeutic/prophylactic agent for OA [39]. We are currently collecting a representative number of OA patients and controls sera samples to determine and compare levels of (i) vitamin K1 and K2 and (ii) c/uc GRP protein forms, for which we are developing an ELISA detection kit (industrial application reported in the international patent request PCT/PT2009000046).…”

Section: Discussionsupporting

confidence: 92%

Insights into the association of Gla‐rich protein and osteoarthritis, novel splice variants and γ‐carboxylation status

Rafael

Cavaco

Viegas

et al. 2014

Molecular Nutrition Food Res

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Section: Discussionsupporting

confidence: 92%

Insights into the association of Gla‐rich protein and osteoarthritis, novel splice variants and γ‐carboxylation status

Rafael

Cavaco

Viegas

et al. 2014

Molecular Nutrition Food Res

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“…[50] Radiographic OA significantly decreased with increased serum levels of vitamin K. A more recent study provided more evidence of vitamin K, as direct measurements of vitamin K2 in the condyles of knees showed that patients with advanced OA had lower levels of vitamin K2. [51] The authors suggested that this provides evidence for the role in which vitamin K may affect bone turnover. [51] However, other studies have shown that vitamin K supplementation does not provide a protective effect on the severity of OA.…”

Section: Dietmentioning

confidence: 99%

“…[51] The authors suggested that this provides evidence for the role in which vitamin K may affect bone turnover. [51] However, other studies have shown that vitamin K supplementation does not provide a protective effect on the severity of OA. [2] Occupation An individual's occupation may predispose him/her to developing OA.…”

Section: Dietmentioning

confidence: 99%

“…One study demonstrated that individuals with low plasma levels of phylloquinone, a form of vitamin K, had increased prevalence of osteophytes, JSN, and OA of the hand and knees [50]. Radiographic OA significantly decreased with increased serum levels of vitamin K. A more recent study provided more evidence of vitamin K, as direct measurements of vitamin K2 in the condyles of knees showed that patients with advanced OA had lower levels of vitamin K2 [51]. The authors suggested that this provides evidence for the role in which vitamin K may affect bone turnover [51].…”

Section: Risk Factorsmentioning

confidence: 99%

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Osteoarthritis of the hand I: aetiology and pathogenesis, risk factors, investigation and diagnosis

Leung

Rainsford

Kean

2013

Journal of Pharmacy and Pharmacology

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Objective Osteoarthritis (OA) of the hand can be a debilitating condition that hinders an individual's quality of life. With multiple joints within the hand that are commonly affected OA, an individual's ability to use their hand in everyday movements become more limited. The article aims to review literature on the aetiology and pathogenesis of OA, risk factors, characteristics of hand OA and the steps of diagnosis. Key findings The aetiology and pathogenesis of OA, in particular hand OA, is not fully understood. However, it is known that several factors play a role. Environmental factors, such as stress from mechanical loading, especially to vulnerable joints predispose individuals to developing OA. Extracellular matrix changes in protein levels have also been noted in individuals with OA. Linked to hand OA development are boney enlargements (Herbeden's and Bouchard's nodes). Several risk factors for OA include: age, obesity, gender, smoking, genetics, diet and occupation. Various diagnostic methods include a combination of using radiographic methods, clinical presentation, a number of developed measurements and scales. Summary With OA having several risk factors and various causes and contributing elements, it is important to elucidate the pathogenesis of OA and determine exactly how risk factors play a role in its development. Because of the contributions from several elements, diagnosis is best when it uses multiple methods. In turn, understanding OA and making better diagnoses could lead to improved management of the condition through both pharmacological and nonpharmacological interventions.

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“…However, this study did not include carboxylation as part of the variables. Ishii et al [30] reported that menaquinone level was significantly higher in the femoral/tibial lateral condyles, compared to medial condyles among patients (n = 58; mean age 73 ± 8 years) with Kellgren-Lawrence (KL) grade 4 undergoing total knee arthroplasty, regardless of age and sex. This observation was possibly contributed by the more severe OA condition at the medial condyles, compared to the lateral side.…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

Chin

2020

Nutrients

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Vitamin K is a cofactor of γ-glutamyl carboxylase, which plays an important role in the activation of γ-carboxyglutamate (gla)-containing proteins that negatively regulate calcification. Thus, vitamin K status might be associated with osteoarthritis (OA), in which cartilage calcification plays a role in the pathogenesis of the disease. This review collates the evidence on the relationship between vitamin K status (circulating or dietary intake level of vitamin K, or circulating uncarboxylated gla proteins) and OA from human observational studies and clinical trial, to examine its potential as an agent in preventing OA. The current literature generally agrees that a sufficient level of vitamin K is associated with a lower risk of OA and pathological joint features. However, evidence from clinical trials is limited. Mechanistic study shows that vitamin K activates matrix gla proteins that inhibit bone morphogenetic protein-mediated cartilage calcification. Gla-rich proteins also inhibit inflammatory cascade in monocytic cell lines, but this function might be independent of vitamin K-carboxylation. Although the current data are insufficient to establish the optimal dose of vitamin K to prevent OA, ensuring sufficient dietary intake seems to protect the elderly from OA.

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Distribution of vitamin K2 in subchondral bone in osteoarthritic knee joints

Cited by 5 publications

References 34 publications

Insights into the association of Gla‐rich protein and osteoarthritis, novel splice variants and γ‐carboxylation status

Insights into the association of Gla‐rich protein and osteoarthritis, novel splice variants and γ‐carboxylation status

Osteoarthritis of the hand I: aetiology and pathogenesis, risk factors, investigation and diagnosis

The Relationship between Vitamin K and Osteoarthritis: A Review of Current Evidence

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