Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain

Eyles, Darryl W.; Smith, Steven A.; Kinobe, Robert T.; Hewison, Martin; McGrath, John J.

doi:10.1016/j.jchemneu.2004.08.006

Cited by 1,255 publications

(979 citation statements)

References 51 publications

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“…It is of particular importance that a novel study in human brains confirmed the presence of the vitamin D receptor as well as genes encoding catalytic enzymes in 1,25(OH) 2 D 3 metabolism in both neuronal and glial cells within brain structures critical for cognition (Zehnder, Bland et al 2001;Burne, JJ et al;Eyles, Smith et al 2005). Furthermore, the VDR and catalytic enzymes were colocalized in the brain; these findings support a functional role for vitamin D in the human brain.…”

Section: Co-localization Of Vdr and 1 25(oh) 2 D 3 In The Brainmentioning

confidence: 71%

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Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

305

219

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Section: Co-localization Of Vdr and 1 25(oh) 2 D 3 In The Brainmentioning

confidence: 71%

“…The protein also increases signal transmission in hippocampal cells which are known to have high levels of VDR mRNA Eyles, Smith et al 2005). Another protective neurotrophin, GDNF, affects the survival and differentiation of dopaminergic cells.…”

Section: 25(oh) 2 D 3 and Neuronal Protectionmentioning

confidence: 99%

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

305

219

View full text Add to dashboard Cite

show abstract

“…mone in tissues, which are not primarily related to mineral metabolism, have been shown within last 30 years. Vitamin D is suggested to act as a neuroactive steroid due to the local bioactivation of the pre-vitamin D hormone in the central nervous system (CNS) and the widely distributed localization of nuclear receptor throughout the brain (Luine et al 1987;Musiol et al 1992;Elaroussi et al 1994;Johnson et al 1996;Veenstra et al 1998;Prufer et al 1999;Miller and Portale 2000;Langub et al 2001;Garcion et al 2002;Burkert et al 2003;Eyles et al 2005;McCann and Ames. 2008;Cekic et al 2009;Dickens et al 2011).…”

Section: Discussionmentioning

confidence: 99%

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Gezen-Ak

Dursun

Bılgıç

et al. 2012

Tohoku J. Exp. Med.

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Vitamin D 3 is a neurosteroid that mediates its effects via the vitamin D receptor (VDR). The VDR gene is located on chromosome 12q13 and consists of 9 exons. VDR contains the DNA-binding site encoded by exons 2 and 3 and the ligand-binding site encoded by exons 4 -9. Our earlier study showed that the ApaI polymorphic site of the VDR gene is associated with late-onset Alzheimer's disease (AD). Here, we investigated the association between additional polymorphisms of the VDR gene and AD using the same samples. Two single nucleotide polymorphisms (SNPs) in intron 8 (BsmI and Tru9I polymorphisms) and one in exon 2 (FokI polymorphism) of the VDR gene were examined in up to 108 AD patients and 115 age-matched controls. Genotypes were determined with polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. Haplotype analysis also included the previously studied polymorphic sites that were recognized by TaqI (in exon 9) and ApaI (in intron 8) restriction enzymes. There was no significant difference between AD patients and controls when their genotypes for BsmI, Tru9I and FokI polymorphic sites were compared. However, the frequency of "TaubF" haplotype (alleles of TaqI, ApaI, Tru9I, BsmI and FokI, respectively), which was determined by analyzing 5 polymorphisms together, was significantly higher in the AD patient group, suggesting that this haplotype is a risk factor in AD. Our results point out a possible link between AD and certain VDR polymorphisms and indicate that individuals with these polymorphisms might be vulnerable to AD.

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“…33 Significant amounts of vitamin D receptors have been revealed in the ventromedial hypothalamus of the human brain, which sends projections to the periaqueductal grey matter and thereby potentially regulates nociceptive signalling through the spinal cord via descending projections of the dorsal horns. 34 Although a biologic explanation for the role of vitamin D in states of chronic pain seems plausible, this view was not supported in a recent meta-analysis. 35 Straube et al 35 conducted a meta-analysis of 22 relevant studies in which they reported vitamin D levels and investigated the effects of vitamin D treatment on chronic pain conditions.…”

Section: Discussionmentioning

confidence: 97%

Low serum vitamin D levels are not associated with increased postoperative pain and opioid requirements: a historical cohort study

Bose

Khanna

You

et al. 2015

Can J Anesth/J Can Anesth

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Purpose Vitamin D deficiency has been associated with chronic non-specific musculoskeletal pain syndromes; however, studies are lacking with respect to its relationship with postoperative pain. We tested the hypothesis that a lower preoperative vitamin D level is associated with increased postoperative pain and/or opioid consumption in morbidly obese patients who had laparoscopic bariatric surgery.

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Distribution of the Vitamin D receptor and 1α-hydroxylase in human brain

Cited by 1,255 publications

References 51 publications

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Vitamin D Receptor Gene Haplotype Is Associated with Late-Onset Alzheimer's Disease

Low serum vitamin D levels are not associated with increased postoperative pain and opioid requirements: a historical cohort study

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