Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (<i>ob/ob</i>)

Mizuno, Márcia Sanae; Crisma, Amanda Rabello; Borelli, Primavera; Schäfer, Barbara; Silveira, Mariana Póvoa; Castelucci, Patrícia

doi:10.3748/wjg.v20.i38.13911

Cited by 13 publications

(8 citation statements)

References 36 publications

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“…Of the P2X receptors, an involvement of both P2X 2 and P2X 7 receptors has been identified. Obesity promoted a decrease in the expression of P2X 2 receptors on enteric neurons of obese male mice [57]. Human adipocytes from metabolic patients express functionally active P2X 7 receptors, which modulate the release of inflammatory molecules such as interleukin-6, tumour necrosis factor-α and p l a s m i n o g e n a c t i v a t o r i n h i b i t o r-1 , i n p a r t v i a inflammasome activation [58].…”

Section: P2x Receptorsmentioning

confidence: 98%

The involvement of purinergic signalling in obesity

Burnstock

Gentile

2018

Purinergic Signalling

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Obesity is a growing worldwide health problem, with an alarming increasing prevalence in developed countries, caused by a dysregulation of energy balance. Currently, no wholly successful pharmacological treatments are available for obesity and related adverse consequences. In recent years, hints obtained from several experimental animal models support the notion that purinergic signalling, acting through ATP-gated ion channels (P2X), G protein-coupled receptors (P2Y) and adenosine receptors (P1), is involved in obesity, both at peripheral and central levels. This review has drawn together, for the first time, the evidence for a promising, much needed novel therapeutic purinergic signalling approach for the treatment of obesity with a ‘proof of concept’ that hopefully could lead to further investigations and clinical trials for the management of obesity.

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Section: P2x Receptorsmentioning

confidence: 98%

The involvement of purinergic signalling in obesity

Burnstock

Gentile

2018

Purinergic Signalling

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“…Furness [26] (2006) emphasized that NOS catalyzes the formation of the NO that is present in the myenteric plexus and neuronal processes in the gut, which acts to relax the muscle fiber function of the gastrointestinal musculature. Previous studies have shown the presence of NOS in the enteric ganglia and muscle fibers under various conditions, such as malnutrition and renutrition [27,28] , ischemia and reperfusion [29][30][31] and obesity [32,33] . The enteric neurons of the ICJ stain positive for NOS, PGP 9.5, and c-kit [3,4,6,8] .…”

Section: Semmentioning

confidence: 99%

Effects of aging on the architecture of the ileocecal junction in rats

Brito

Chopard

Cury

et al. 2016

WJGPT

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AIM:To evaluate the structural organization of the elastic and collagen fibers in the region of the ileocecal transition in 30 young and old male Wistar rats. METHODS:Histology, immunohistochemistry (IHC), transmission electron microscopy and scanning electron microscopy were employed in this study. The results demonstrated that there was a demarcation of the ileocecal region between the ileum and the cecum in both groups. RESULTS:The connective tissue fibers had different distribution patterns in the two groups. IHC revealed the presence of nitric oxide synthase, enteric neurons and smooth muscle fibers in the ileocecal junctions (ICJs) of both groups. Compared to the young group, the elderly group exhibited an increase in collagen type Ⅰ fibers, a decrease in collagen type Ⅲ fibers, a decreased linear density of oxytalan elastic fibers, and a greater linear density of elaunin and mature elastic fibers. CONCLUSION:The results revealed changes in the patterns of distribution of collagen and elastic fibers that may lead to a possible decrease in ICJ functionality. Core tip: The ileocolonic sphincter controls the forward and backward flow by integrating its motility with that of the distal ileum and proximal the ileocolonic sphincter controls the forward and backward flow by integrating its motility with that of the distal ileum and proxima. The ileocecal junction (ICJ) includes the muscle bundles in the terminal ileum, the intrinsic nerve plexus. The ICJ includes the muscle bundles in the terminal ileum, the intrinsic nerve plexus. Given the importance of knowing how the ICJ changes with age, the objective of this study was to characterize the morphological changes in the ICJ in rats aged 21 d and 2 years, using optical microscopy and electronic scanning and transmission methodologies. Additionally, the neurochemical characterization of the inhibitory neurons of the myenteric plexus, which are immunoreactive to the enzyme nitric oxide synthase, and the staining of the neuronal population were employed to identify immunoreactivity to HuC/D.de Brito MC, Chopard RP, Cury DP, Watanabe IS, Mendes CE, Castelucci P. Effects of aging on the architecture of the ileocecal junction in rats.

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“…Estes plexos podem sofrer alterações frente a diversos protocolos como: desnutrição/renutrição (CASTELUCCI et al, 2002a;GIROTTI et al, 2013;MISAWA et al, 2010), obesidade (MIZUNO et al 2014(MIZUNO et al , 2012 e isquemia/reperfusão (MAROSTI et al, 2015;MENDES et al, 2015;PALOMBIT et al, 2013;PAULINO et al, 2011) e inflamação intestinal (DA SILVA et al, 2015).…”

Section: Sistema Nervoso Entéricounclassified

Estudo do efeito dos antagonistas do receptor P2X7 e Panexina-1 nas células gliais entéricas no protocolo de isquemia e reperfusão intestinal.

Mendes¹

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Distribution of the P2X2 receptor and chemical coding in ileal enteric neurons of obese male mice (ob/ob)

Abstract: Obesity may exert its effects by promoting a decrease in P2X2 receptor expression and modifications in the density of the NOS-ir, ChAT-ir and CalR-ir myenteric neurons.

Cited by 13 publications

References 36 publications

The involvement of purinergic signalling in obesity

The involvement of purinergic signalling in obesity

Effects of aging on the architecture of the ileocecal junction in rats

Estudo do efeito dos antagonistas do receptor P2X7 e Panexina-1 nas células gliais entéricas no protocolo de isquemia e reperfusão intestinal.

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