Distribution of the major histocompatibility complex antigens on different cellular components of human liver

Lautenschlager, Irmeli; Taskinen, Eero; Inkinen, Kaija; Lehto, Veli‐Pekka; Virtanen, Ismo; Häyry, P

doi:10.1016/0008-8749(84)90289-2

Cited by 53 publications

(22 citation statements)

References 21 publications

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“…Biopsies read as histologically normal in this and other studies, and which express HLA-A, -B, -C, may not represent 'normal' liver, with unrecognised immunological factors or agents such as drugs or alcohol promoting the expression of HLA products at the hepatocyte membrane. This may explain the variable findings in the different series reported to date (Saunders et al, 1979;Montano et al, 1982;Ponder et al, 1983;Lautenschlager et al, 1984;Nagafuchi et al, 1985;Fukusato et al, 1986;Nagafuchi & Scheuer, 1986 (Fukusato et al, 1986;Mazzeo et al, 1986).…”

Section: Discussionmentioning

confidence: 53%

“…Their distribution is more restricted than was originally held (Daar et al, 1984). The situation pertaining to hepatocytes is uncertain with some workers failing to detect them on normal liver cells (Ponder et al, 1983;Lautenschlager et al, 1984;Fukusato et al, 1986) and others reporting their presence at low levels (Saunders et al, 1979;Montano et al, 1982;Nagafuchi et al, 1985;Nagafuchi & Scheuer, 1986).…”

mentioning

confidence: 98%

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HLA expression in human hepatocellular carcinoma

Paterson

Sciot²,

Kew³

et al. 1988

Br J Cancer

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Section: Discussionmentioning

confidence: 53%

mentioning

confidence: 98%

HLA expression in human hepatocellular carcinoma

Paterson

Sciot²,

Kew³

et al. 1988

Br J Cancer

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“…These alterations could be caused by mutation, recombination, or activation of normal MHC genes (8,9). Recent studies on human and mouse liver tissues indicated that neither class I nor class II MHC antigens were detectable on the surface of normal hepatocytes (10)(11)(12)(13)(14). On the other hand, it was discovered that hepatocytes of human patients with acute and chronic active hepatitis expressed MHC class I antigens (11)(12)(13), and that HBc antigen-containing hepatocytes may also express class II antigen (15).…”

Section: Introductionmentioning

confidence: 99%

Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma.

Sung¹,

Hu²,

Hsu³

et al. 1989

J. Clin. Invest.

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Previous reports indicate that human hepatocytes do not express class I and class II MHC antigens. Our analyses on 10 human hepatocellular carcinoma (HCC) cell lines by immunofluorescence tests and RIA, demonstrate that all the human HCC cell lines tested express class I MHC antigens and among them, three poorly differentiated human HCC cell lines also express class II MHC antigens. Results of immunoprecipitation and/or Western blotting experiments indicate similarity in the chemical nature of both the class I and class II MHC antigens expressed by the human HCC cell lines and by a human B lymphoblastoid cell line Raji. Furthermore, a new variant form of class I antigen was detected in some of these HCC cell lines. Immunohistochemical studies of HCC tissues using the peroxidase-antiperoxidase staining method indicated that class I and class II antigens were detectable in 7 out of 11 and 3 out of 11 HCC tissues from patients, respectively. The availability of MHC class I antigen-positive cultured HCC cell lines, including the poorly differentiated lines that also express MHC class II antigen, has provided us with interesting models to study the relationship between expression of MHC antigen and transformation and differentiation of human hepatocytes. These studies will also allow us some insight into the role of MHC class I and class II antigen in the immunosensitivity and immunogenecity of HCC cells to the host-immune response.

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“…Additionally, CMV could be demonstrated in all but 2 of the PCR-positive specimens by at least one additional technique. As shown before, the molecular biological techniques provide a higher sensitivity for CMV detection in liver biopsy specimens than immunohistology, histological analysis or virus culture [25][26][27].…”

Section: Discussionmentioning

confidence: 94%

Cytomegalovirus in liver biopsies of marrow transplant recipients: detection methods, clinical, histological and immunohistological features

Einsele¹,

Waller²,

Weber

et al. 1994

Med Microbiol Immunol

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In a retrospective analysis liver biopsy specimens obtained from 44 marrow transplant recipients were studied to evaluate the frequency of local presence of human cytomegalovirus (CMV) and graft-versus-host disease (GvHD)-like histological and immunohistological alterations in patients with and without liver dysfunction following bone marrow transplantation (BMT). In 22 of 28 patients with marked liver dysfunction after BMT and histopathological alterations described as typical for acute GvHD CMV could be detected in the liver biopsy specimen. The polymerase chain reaction (PCR) technique revealed the highest sensitivity for CMV detection in liver biopsy samples, but in 20 of 22 PCR-positive specimens CMV infection could be confirmed by at least one additional technique. All the liver biopsies obtained from 16 patients with normal liver function lacking histopathological signs of GvHD were CMV negative. In all 3 patients with CMV-positive liver biopsy started on antiviral therapy liver function improved and no generalized CMV disease occurred. All the 4 patients without local presence of CMV started on severe immunosuppressive therapy showed an improvement of liver dysfunction without occurrence of CMV infection. Local CMV infection of the liver could not be differentiated from hepatic GvHD by clinical and histopathological features, nor by immunohistological analysis of the bile duct epithelium. In contrast, only in liver biopsy with local viral presence could an increase in HLA class II- and ICAM-1 expression be demonstrated on hepatocytes. Thus, especially the high negative predictive value of the PCR technique helps to manage the patient with liver dysfunction after BMT.

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Distribution of the major histocompatibility complex antigens on different cellular components of human liver

Cited by 53 publications

References 21 publications

HLA expression in human hepatocellular carcinoma

HLA expression in human hepatocellular carcinoma

Expression of class I and class II major histocompatibility antigens on human hepatocellular carcinoma.

Cytomegalovirus in liver biopsies of marrow transplant recipients: detection methods, clinical, histological and immunohistological features

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