Distribution of theIL-1RN,IL-6,IL-10,INF-γ, andTNF-αGene Polymorphisms in the Mexican Population

Vargas‐Alarcón, Gilberto; Ramírez‐Bello, Julián; Juárez‐Cedillo, Teresa; Ramírez-Fuentes, Silvestre; Carrillo-Sánchez, Silvia; Fragoso, José Manuel

doi:10.1089/gtmb.2012.0100

Cited by 23 publications

(23 citation statements)

References 36 publications

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“…The frequency of allele –308A was not higher than 10% in Mestizos. This polymorphism seems to be very similarly distributed among Mexicans , and in general, for some Latin‐American populations, such as Colombians, Venezuelans, and Argentineans , with only two exceptional Mexican cases, in which allele A accounted for 20% of the frequency in individuals from the state of Nuevo Leon and Mexico City . Moreover, in European and African populations, the frequency of this allele ranges from 5% to 23% ; in particular, in the Spanish and the Portuguese, these values reach 15% and 24%, respectively.…”

Section: Discussionmentioning

confidence: 90%

“…Polymorphisms at the TNF locus have been extensively studied worldwide, and a great genetic diversity has been found according to ethnicity and geographical region , which could have a differential epidemiological impact within each population. In Mexico, several studies have examined the influence of the polymorphism TNFA–308G>A in different clinical settings and geographic regions . However, the variability of this and other TNF polymorphisms among the Mexican population (both Mestizo and native) is unknown .…”

Section: Introductionmentioning

confidence: 99%

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Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

et al. 2014

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The so-called tumor necrosis factor (TNF) block includes the TNFA, lymphotoxin alpha and beta (LTA and LTB) genes with single-nucleotide polymorphisms (SNP) and microsatellites with an allele frequency that exhibits interpopulation variability. To date, no reports have included both SNPs and microsatellites at the TNF block to study Mestizo or Amerindian populations from Mexico. In this study, samples of five Mexican Mestizo populations (Durango, Guadalajara, Monterrey, Puebla, and Tierra Blanca) and four native-Mexican populations (North Lacandonians, South Lacandonians, Tepehuanos, and Yaquis) were genotyped for two SNPs (LTA+252A>G and TNFA-308G>A) and four microsatellites (TNFa, d, e, and f), to analyze the genetic substructure of the Mexican population. Allele and haplotype frequencies, linkage disequilibrium (LD), and interpopulation genetic relationships were calculated. There was significant LD along almost all of the TNF block but the lowest D' values were observed for the TNFf-TNFd pair. Mestizos showed higher allele and haplotype diversity than did natives. The genetic differentiation level was reduced among Mestizos; however, a slightly, but significant genetic substructure was observed between northern and southern Mexican Mestizos. Among the Amerindian populations, the genetic differentiation level was significantly elevated, particularly in both North and South Lacandonians. Furthermore, among Southern Lacandonians, inhabitants of Lacanja town were the most differentiated from all the Mexicans analyzed. The data presented here will serve as a reference for further population and epidemiological studies including these TNF polymorphisms in the Mexican population.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

et al. 2014

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“…The sample population showed a predominant heterozygous genotype (49%) and C allele (~60%) expression in the IL10 -819 C>T and IL10 -592 C>A polymorphisms, respectively. The allele and genotype frequencies of the IL-10 SNPs in Mexican Mestizos from the west were compared to the frequencies reported in a previous study of Mexican Mestizos from the central region (Mexico city) (Vargas-Alarcon et al, 2012), as well as those in populations belonging to the Asian (Liu et al, 2010;Hua et al, 2013), African (Meenagh et al, 2002), and European (Boiardi et al, 2006;Scarpelli et al, 2006) ethnic groups. We observed no differences in the genotypic and allelic frequencies of these SNPs in Mexican Mestizos from the central and western regions.…”

Section: Allele and Genotype Frequenciesmentioning

confidence: 99%

Frequency distribution of interleukin-10 haplotypes (-1082 A>G, -819 C>T, and -592 C>A) in a Mexican population

et al. 2016

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Interleukin 10 (IL-10) is an immunoregulatory cytokine with multiple roles in the immune system. Three single nucleotide polymorphisms at positions -1082 (A>G), -819 (C>T), and -592 (C>A) in the promoter region of the IL10 gene are believed to be associated with different inflammatory, infectious, and autoimmune diseases. These polymorphisms exhibit a strong linkage disequilibrium (LD) and form three principal haplotypes (GCC, ACC, and ATA). The GCC and ATA haplotypes have been associated with high and low levels of IL-10 production, respectively. The aim of this study was to establish the allele and haplotype frequencies of the IL10 polymorphisms in Mestizos from western Mexico. SNPs were analyzed in 340 healthy unrelated Mestizos from western Mexico by polymerase chain reaction-restriction fragment length polymorphism. The studied population presented significant differences, in the distribution of IL10 polymorphisms, from the Asian, African, and European populations. We also observed a strong LD within -1082 A>G, -819 C>T, and -592 C>A (100% pc = 7.735 x 10). The haplotypes ACC (45.4%), ATA (22.0%), GTA (14.9%), and GCC (13.9%) were most frequently observed in this population. The haplotype frequencies, however, differed from those reported previously in Mestizos from central Mexico, Asians, Africans, and European Caucasians, suggesting a differential gene flow in the Mexican Mestizo population. This could account for the genetic variability between Mexicans and populations of other ethnicities. The study of these polymorphisms and their haplotypes could help in expanding our knowledge to design future disease-risk studies on the western Mexican population.

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“…32 It has also been demonstrated that the IL-38 polymorphism (rs3811058), is significantly differentially distributed in a Mexican population when compared to Caucasian, Asian, and African populations. 33 Although these studies do not directly identify a role for IL-38 in disease, they provide evidence that functional biology of IL-38 is important to understand since this might reveal new mechanisms of disease.…”

Section: Association Studiesmentioning

confidence: 99%

Biology of IL‐38 and its role in disease

Veerdonk

Graaf

Joosten

et al. 2017

Immunological Reviews

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IL-38 belongs to the IL-36 cytokines, which in turn are part of the IL-1 family. The first biological function of IL-38 described was blocking the activation of the IL-36R signaling similar to IL-36Ra. Since IL-36 cytokines require processing in order to become fully active, it is likely that IL-38 also must be processed to become maximally active. However, the protease(s) responsible for this is currently not known. In addition of IL-38 binding IL-36R, it has been proposed it can also interact with the co-receptor TIGIRR2. IL-38 is expressed in several tissues including tonsils, placenta, heart and brain, and IL-38 has been implicated in a wide variety of diseases including cardiovascular and autoimmune disease. Here, we discuss the discovery and biological function of IL-38, and its role in the pathogenesis of a wide variety of diseases.

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Distribution of theIL-1RN,IL-6,IL-10,INF-γ, andTNF-αGene Polymorphisms in the Mexican Population

Cited by 23 publications

References 36 publications

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

Tumor necrosis factor haplotype diversity in Mestizo and Native populations of Mexico

Frequency distribution of interleukin-10 haplotypes (-1082 A>G, -819 C>T, and -592 C>A) in a Mexican population

Biology of IL‐38 and its role in disease

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