Distribution of the Antibody to Influenza C Virus in Dogs and Pigs in Yamagata Prefecture, Japan

Ohwada, Kazuo; Kitame, Fumio; Sugawara, Kanetsu; Nishimura, Hidekazu; Homma, M.; Nakamura, Kenzo

doi:10.1111/j.1348-0421.1987.tb01351.x

Cited by 34 publications

(26 citation statements)

References 16 publications

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“…Furthermore, human influenza C virus isolates were found to be closely related to pig isolates, suggesting that interspecies transmission of influenza C virus between humans and pigs has occurred in nature (24). Influenza C virus-specific antibodies were also detected in dogs (26,27,39), but detection or isolation of the virus from this animal species has not been documented, although experimental infection resulted in clinical symptoms and viral replication (38). Consequently, influenza C viruses are not restricted to humans, but the potential role of pigs or dogs as an animal reservoir for human influenza C virus remains to be elucidated.…”

mentioning

confidence: 86%

Rescue of Influenza C Virus from Recombinant DNA

Crescenzo-Chaigne

Werf

2007

J Virol

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The rescue of influenza viruses by reverse genetics has been described only for the influenza A and B viruses. Based on a similar approach, we developed a reverse-genetics system that allows the production of influenza C viruses entirely from cloned cDNA. The complete sequences of the 3 and 5 noncoding regions of type C influenza virus C/Johannesburg/1/66 necessary for the cloning of the cDNA were determined for the seven genomic segments. Human embryonic kidney cells (293T) were transfected simultaneously with seven plasmids that direct the synthesis of each of the seven viral RNA segments of the C/JHB/1/66 virus under the control of the human RNA polymerase I promoter and with four plasmids encoding the viral nucleoprotein and the PB2, PB1, and P3 proteins of the viral polymerase complex. This strategy yielded between 10 3 and 10 4 PFU of virus per ml of supernatant at 8 to 10 days posttransfection. Additional viruses with substitutions introduced in the hemagglutinin-esterase-fusion protein were successfully produced by this method, and their growth phenotype was evaluated. This efficient system, which does not require helper virus infection, should be useful in viral mutagenesis studies and for generation of expression vectors from type C influenza virus.

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confidence: 86%

Rescue of Influenza C Virus from Recombinant DNA

Crescenzo-Chaigne

Werf

2007

J Virol

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“…The influenza C virus has also been found in pigs, and there are some reports about interspecies transmission of the virus between humans and pigs [6,7]. However, pigs are not considered to play a significant role in the transmission cycle of the viruses in humans [7,8]. …”

Section: Introductionmentioning

confidence: 99%

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

Furuse

Matsuzaki

Nishimura

et al. 2016

Viruses

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Infections with the influenza C virus causing respiratory symptoms are common, particularly among children. Since isolation and detection of the virus are rarely performed, compared with influenza A and B viruses, the small number of available sequences of the virus makes it difficult to analyze its evolutionary dynamics. Recently, we reported the full genome sequence of 102 strains of the virus. Here, we exploited the data to elucidate the evolutionary characteristics and phylodynamics of the virus compared with influenza A and B viruses. Along with our data, we obtained public sequence data of the hemagglutinin-esterase gene of the virus; the dataset consists of 218 unique sequences of the virus collected from 14 countries between 1947 and 2014. Informatics analyses revealed that (1) multiple lineages have been circulating globally; (2) there have been weak and infrequent selective bottlenecks; (3) the evolutionary rate is low because of weak positive selection and a low capability to induce mutations; and (4) there is no significant positive selection although a few mutations affecting its antigenicity have been induced. The unique evolutionary dynamics of the influenza C virus must be shaped by multiple factors, including virological, immunological, and epidemiological characteristics.

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“…A cohort study in a child-care house has demonstrated that influenza C virus can repeatedly infect individuals who have antibodies against the virus [8,9]. Besides humans, pigs and dogs were reported to have antibodies against influenza C virus [11,21,26].…”

Section: Summary Multiplication Of Influenza C Virus In Mdck Cell Cumentioning

confidence: 98%

MDCK cell cultures supplemented with high concentrations of trypsin exhibit remarkable susceptibility to influenza C virus

Yamaoka

Homma

Hotta

1995

Archives of Virology

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Multiplication of influenza C virus in MDCK cell cultures increased with increasing concentrations of trypsin up to 160 micrograms/ml, whereas maximum growth of influenza A virus in the same culture was observed at a concentration of 10 micrograms/ml. In the presence of 160 micrograms of trypsin per ml MDCK cells showed the same or even higher susceptibility to various strains of influenza C virus compared with HMV-II cells, a human melanoma cell line that has been reported to have high susceptibility to the virus. Complete cleavage of the HE precursor protein of MDCK-grown influenza C virus into HE1 and HE2 subunits was achieved by trypsin at a concentration of 160 micrograms/ml, whereas only partial cleavage was observed at 10 micrograms/ml. The present results thus demonstrate that MDCK cell cultures supplemented with trypsin at a concentration of 160 micrograms/ml become highly susceptible to influenza C virus.

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Distribution of the Antibody to Influenza C Virus in Dogs and Pigs in Yamagata Prefecture, Japan

Cited by 34 publications

References 16 publications

Rescue of Influenza C Virus from Recombinant DNA

Rescue of Influenza C Virus from Recombinant DNA

Analyses of Evolutionary Characteristics of the Hemagglutinin-Esterase Gene of Influenza C Virus during a Period of 68 Years Reveals Evolutionary Patterns Different from Influenza A and B Viruses

MDCK cell cultures supplemented with high concentrations of trypsin exhibit remarkable susceptibility to influenza C virus

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