Distribution of Th1, Th2, and Th0 and the Th1/Th2 Cell Ratios in Human Peripheral and Endometrial T Cells

Saito, Shigeru; Tsukaguchi, Nobuhiko; Hasegawa, Takashi; Michimata, Toshihiko; Tsuda, Hiroshi; Narita, Nobuhiro

doi:10.1111/j.1600-0897.1999.tb00097.x

Cited by 123 publications

(84 citation statements)

References 33 publications

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“…Pregnancy had been thought to be an immuno-suppressed condition, but maternal lymphocytes were activated and clearly secreted most cytokines in the human deciduas. Saito et al [18,19] suggested that during pregnancy, Th1 cell function was restrained and it became clear that the Th2 cell function became dominant in mice and humans. IL-6 was identified in placenta, amnion, deciduas and myometrium [5].…”

Section: Discussionmentioning

confidence: 99%

“…Local immune cells or cytokines in the uterus played roles in maintaining pregnancy, support fetal growth and preventing infection [19]. The authors think that it is especially important for elimination of the fetal membrane and phylaxis after parturition to shift from T-helper 2-type (Th2) cell dominance to T-helper 1-type (Th1) cell dominance of T-helper cells in the intrauterine immune system around parturition.…”

mentioning

confidence: 99%

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Changes in Interleukin-6 Concentration in Peripheral Blood of Pre- and Post-Partum Dairy Cattle and Its Relationship to Postpartum Reproductive Diseases

Ishikawa

Nakada

Hagiwara

et al. 2004

The Journal of Veterinary Medical Science

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ABSTRACT. Reproductive diseases after parturition are a serious problem in dairy cattle. It is important to predict postpartum reproducti ve diseases early and to develop prophylaxis. The objectives of this study were to demonstrate changes in the peripheral blood con centration of interleukin-6 (IL-6) before parturition, which was mainly produced by T helper 2 type (Th2) cells, and to investigate a correlation between the IL-6 concentration and the occurrence of the postpartum retained placenta, endometritis and/or follicular cyst in da iry cattle. Twenty-seven Holstein-Friesian cows were used for this study. Thirteen had no clinical disease, 8 had retained placenta, 4 were diagnosed with endometritis by vaginal inspection, and 2 were diagnosed with follicular cyst by rectal palpation at 1 and 2 months a fter parturition. Blood samples were collected 60 days pre-and post-partum. They used for IL-6, progesterone (P 4 ) and estradiol-17β (E 2 ) concentration determination. This study showed that the IL-6 concentration prepartum was higher than postpartum. Low levels of IL-6 and P 4 in peripheral blood prepartum tended to affect retained placenta and a high level of IL-6 prepartum tended to affect endometrit is. These results indicate that measurement of change in the IL-6 concentration during pregnancy is one useful tool for predicting crisis in postpartum reproductive diseases in dairy cattle. KEY WORDS: cattle, endometritis, interleukin-6, pregnant, retained placenta.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Changes in Interleukin-6 Concentration in Peripheral Blood of Pre- and Post-Partum Dairy Cattle and Its Relationship to Postpartum Reproductive Diseases

Ishikawa

Nakada

Hagiwara

et al. 2004

The Journal of Veterinary Medical Science

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“…Normal human pregnancies are distinguished by a Th2 bias (Poole and Claman, 2004;Kidd, 2003;Sacks et al, 2003;Suzuki and Okudaira, 2004;Shimaoka et al, 2000;Lim et al, 2000;Piccinni et al, 2000;Saito et al, 1999). The shift from Th1 cytokine production to Th2 cytokine production protects the semi-allogeneic fetus from rejection by the maternal immune system, but as gestation progresses a shift from a predominate Th2 response to a Th1 response occurs (Raghupathy et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: Determinations of a panel of nine cytokines in clinical sample culture supernatants

duPont¹,

Wang

Wadhwa

et al. 2005

Journal of Reproductive Immunology

269

181

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Problem: Analyses of the expression pattern of multiple cytokines are frequently required for characterization of the status of the immune system as it pertains to Th type bias and intrinsic levels of inflammation. Classically, analysis of cytokine expression patterns has been performed by enzymelinked immunosorbent assays (ELISA) for each separate analyte. A new technology, Luminex MAP ® , facilitates the simultaneous evaluation of multiple immune mediators with advantages of higher throughput, smaller sample volume, and lower cost. Validation of this technology has been limited to small sample sets, limited use of clinical study specimens, and use of non-commercial reagents. * Corresponding author. Methods: Ninety-six specimens from women over the course of their respective pregnancies were evaluated for cytokine concentrations using commercially available ELISA kits and commercially available Luminex MAP ® kits according to the manufacturers' directions. Correlations between data sets were evaluated using Pearson's correlation coefficient (r).Results: Excellent correlations were demonstrated for IL-1␤, IL-4, IL-5, IL-6, IL-10, IFN ␥, and TNF ␣, in contrast to IL-12 p70 and IL-13. Conclusions: Luminex multiplex technology has distinct advantages and is a valid alternative method to ELISA for the evaluation of the majority of cytokines tested and for the characterization of immune system status.

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“…Thus, subsets of uNK cells in Tg2Rβ mice could emerge at the time-mismatched pregnant days. Indeed, in human, successful pregnancy depends on which helper T cell subset, i.e., Th1 or Th2, is predominant [10,11]. The same mechanism might also be involved in successful pregnancy in murine uNK cells.…”

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confidence: 99%

A Study of Reproductive Performance in Pregnant, IL-2 Receptor .BETA.-chain Overexpressed Transgenic Mice.

Namba

Hondo

Morimoto

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. Relationships between female reproductive performance and uterine natural killer (uNK) cells were investigated in pregnant IL-2 receptor β-chain overexpressed transgenic (Tg2Rβ) mice. At 8 days of pregnancy, all fetuses were alive, suggesting that implantation normally occurred in these mice. However, 47% of fetuses were dead at 10 days of pregnancy and at 12 days all fetuses were resorbing, indicating that fetal loss progressed with the advance of pregnancy. The placenta of Tg2Rβ mice gradually decreased in weight with the advance of pregnancy. At 10 days the placental labyrinth, decidua basalis, and metrial gland in Tg2Rβ mice were poorly developed, and more uNK cells were found in Tg2Rβ mice than in the control mice. We propose that Tg2Rβ mice are the first and interesting model that uNK cells can cause abortion, to clarify the involvement of uNK cell function in female reproductive performance. KEY WORDS: IL-2 receptor β-chain overexpression, placenta, transgenic mouse.

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Distribution of Th1, Th2, and Th0 and the Th1/Th2 Cell Ratios in Human Peripheral and Endometrial T Cells

Abstract: These data indicate that Th1 cells predominate in the nonpregnant endometrium, especially during the proliferative phase, while Th2 cells predominate in early pregnancy decidua.

Cited by 123 publications

References 33 publications

Changes in Interleukin-6 Concentration in Peripheral Blood of Pre- and Post-Partum Dairy Cattle and Its Relationship to Postpartum Reproductive Diseases

Changes in Interleukin-6 Concentration in Peripheral Blood of Pre- and Post-Partum Dairy Cattle and Its Relationship to Postpartum Reproductive Diseases

Validation and comparison of luminex multiplex cytokine analysis kits with ELISA: Determinations of a panel of nine cytokines in clinical sample culture supernatants

A Study of Reproductive Performance in Pregnant, IL-2 Receptor .BETA.-chain Overexpressed Transgenic Mice.

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