Distribution of telocytes in the corpus and cervix of human uterus: an immunohistochemical study

Klein, Martin; Urban, Lukáš; Deckov, Ivan; Danišovič, Ľuboš; Polák, Štefan; Danihel, Ľ; Varga, Ivan

doi:10.1515/biolog-2017-0134

Cited by 10 publications

(5 citation statements)

References 36 publications

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“…They express CD 117, CD 34, vimentin [48], ER, and PR [36]. Our own previous experiments also demonstrated that uterine TCs are CD 117 positive in different histological layers of both the uterine body and cervix, with the strongest positivity found in the myometrium [49]. Apart from these typical markers, Hatta et al and Rosenbaum et al demonstrated that uterine TCs are positive for connexin 43 and SK3 channels, respectively [47,50,51].…”

Section: Immunophenotype Of Frs Telocytesmentioning

confidence: 80%

Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications

Klein

Csöbönyeiová

Danišovič

et al. 2022

Life

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From their initial description in 2005 to this day, telocytes (TCs) have been described in the ovary, uterine tubes, uterus, vagina, mammary gland, and placenta. Their morphological features, immunophenotype, physiological functions, and roles in disease have been thoroughly documented in both animal models and human subjects. TCs, with their extremely long cytoplasmic processes called telopodes, play a pivotal role in the morphological and functional interconnection of all the components of the interstitial compartment, but also with constituents of the parenchyma. Although there is no specific immunohistochemical marker for their identification, the most cited are CD 117, CD 34, platelet-derived growth factor receptor (PDGFR), vimentin, and specific markers typical for the female reproductive system (FRS)—estrogen and progesterone receptors (ER and PR). This immunophenotype provides important clues to their physiological roles. Their main functions include the regulation of hormone-dependent processes, intercellular signaling, immune surveillance, microenvironmental maintenance, and the nursing of stem cells. In a situation where TCs are functionally or morphologically decimated, many disease entities may develop, including premature ovarian failure, endometriosis, ectopic pregnancy, infertility, preeclampsia, or even breast cancer. The common denominator of many of these conditions is that their etiopathogenesis is either partially known or completely obscure. Even though the exact role of TCs in these conditions is yet to be revealed, multiple lines of research indicate that their future clinical application may enrich diagnostic-therapeutic strategies of countless conditions. TCs are also heavily debated in terms of their possible use in regenerative medicine and tissue engineering. Some of the concepts related to TC research are strongly substantiated by experimental data, while others are highly speculative. Only future research endeavors will clearly distinguish dead-end lines of research from genuine contributions to the field.

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Section: Immunophenotype Of Frs Telocytesmentioning

confidence: 80%

Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications

Klein

Csöbönyeiová

Danišovič

et al. 2022

Life

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“…Vimentin is cytoskeletal type III intermediate filament protein found in mesenchymal-derived cells that provides an architectural network for organelles anchoring to cytoplasm [73]. CD117 is a transmembrane receptor tyrosine kinase widely used for TCs identification which is active in proliferation and differentiation [77]. Based on two distinct double-immunostainings for CD34/CD117 and CD34/Vimentin, skeletal muscle TCs were identified in all groups.…”

Section: Discussionmentioning

confidence: 99%

Morphological Evidence of Telocytes in Skeletal Muscle Interstitium of Exercised and Sedentary Rodents

et al. 2021

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Skeletal muscle atrophy, resulting from states of hypokinesis or immobilization, leads to morphological, metabolic, and functional changes within the muscle tissue, a large variety of which are supported by the stromal cells populating the interstitium. Telocytes represent a recently discovered population of stromal cells, which has been increasingly identified in several human organs and appears to participate in sustaining cross-talk, promoting regenerative mechanisms and supporting differentiation of local stem cell niche. The aim of this morphologic study was to investigate the presence of Telocytes in the tibialis anterior muscle of healthy rats undergoing an endurance training protocol for either 4 weeks or 16 weeks compared to sedentary rats. Histomorphometric analysis of muscle fibers diameter revealed muscle atrophy in sedentary rats. Telocytes were identified by double-positive immunofluorescence staining for CD34/CD117 and CD34/vimentin. The results showed that Telocytes were significantly reduced in sedentary rats at 16 weeks, while rats subjected to regular exercise maintained a stable Telocytes population after 16 weeks. Understanding of the relationship between Telocytes and exercise offers new chances in the field of regenerative medicine, suggesting possible triggers for Telocytes in sarcopenia and other musculoskeletal disorders, promoting adapted physical activity and rehabilitation programmes in clinical practice.

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“…The morphological and topographical differences between the majority of these c-kit-positive cells are well known, so the cells should not be mistaken for each other. According to our previous results, immunohistochemical staining for c-kit appears to be the most suitable method for the detection and description of telocytes in the female genital tract (Urban et al 2016;Klein et al 2017).…”

Section: Question 3 Is It Possible To Identify Telocytes Using Monocmentioning

confidence: 96%

Recently discovered interstitial cells termed telocytes: distinguishing cell-biological and histological facts from fictions

et al. 2018

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Distribution of telocytes in the corpus and cervix of human uterus: an immunohistochemical study

Cited by 10 publications

References 36 publications

Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications

Telocytes in the Female Reproductive System: Up-to-Date Knowledge, Challenges and Possible Clinical Applications

Morphological Evidence of Telocytes in Skeletal Muscle Interstitium of Exercised and Sedentary Rodents

Recently discovered interstitial cells termed telocytes: distinguishing cell-biological and histological facts from fictions

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