Distribution of T and B lymphocytes in jejunal and ileocaecal Peyer's patches of lambs

Larsen, H.J.S.; Landsverk, Thor

doi:10.1016/s0034-5288(18)30494-6

Cited by 34 publications

(28 citation statements)

References 13 publications

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“…Both MIg + lymphocytes and particles are found in the medullary area of the follicles but are absent from the cortical zone where the MIg lymphocytes are found (10). It is therefore possible that the particles play a role in the events triggering the transition frotn MIg-to Mlg + lymphocytes.…”

Section: Discussionmentioning

confidence: 99%

Carbonic anhydrase—a marker for particles shed from the epithelium to the lymphoid follicles of the ileal Peyer's patch in goat kids and lambs

Landsverk

Jansson

Nicander³

et al. 1987

Immunol Cell Biol

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Summary Carbonic anhydrase (CA) was found to be a marker for 50 nanometer membrane‐bounded particles shed from the lateral cell border of follicle‐associated epithelial cells (FAE) in the ileal Peyer's patch (PP) of pre‐ and post‐natal lambs and goat kids. The CA‐positive particles seemed to filter into the underlying lymphoid tissue where they formed part of the matrix embedding the cells of the follicle centre.

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Section: Discussionmentioning

confidence: 99%

Carbonic anhydrase—a marker for particles shed from the epithelium to the lymphoid follicles of the ileal Peyer's patch in goat kids and lambs

Landsverk

Jansson

Nicander³

et al. 1987

Immunol Cell Biol

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“…The more developed capsule of the ileal PP creates a sac-like structure with a narrow neck portion and this may contribute to the remarkable segregation of cells characteristic for the ileal PP. The follicle cell population is largely restricted to IgM+ lymphocytes, macrophages resembling tingible body macrophages, and FDC-like cells (Larsen and Landsverk, 1986;Hein et al, 1989;Halleraker et al, 1990). Thus, the capsule could contribute to a secluded environment for B lymphocytes which may be essential to its assumed primary lymphoid function.…”

Section: Discussionmentioning

confidence: 99%

Ontogeny of reticular cells in the ileal Peyer's patch of sheep and goats

Nicander¹,

Halleraker²,

Landsverk³

1991

Am. J. Anat.

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The ontogeny of reticular cells in the ileal Peyer's patch of sheep from 70 days gestational age was studied by light and electron microscopy and by enzyme histochemistry. Small to medium-sized lymphocytes were seen in the lamina propria at 97 days, when the stroma was essentially still mesenchymal. By 110 days, the stromal cells in the dome/follicle primordia had differentiated into reticular fibroblasts, whose processes and fibers were seen to surround groups of lymphocytes. With advancing age the number and size of primordia increased, and proliferation was obvious among the lymphocytes. Processes of reticular cells increased in number and penetrated between individual lymphocytes of the groups. Coarser desmosome-like contacts were seen between the reticular cells from 115 days onwards. A central light area in the follicle was apparent from 130 days onwards. The fine structure of the stromal cells in this light follicle center developed towards but never became similar to that of follicular dendritic cells in a typical germinal center. The fine interdigitating end branches of the stromal cells were less numerous, and the dense homogeneous material present in between the end branches was not observed in the ileal Peyer's patch follicle. Instead, small particles and vesicles were seen between the various cell types of the light center and were not restricted to the intercellular spaces between the stromal cells. In the dark peripheral zone of the follicle, the stromal cells retained more immature features. The follicle became bordered by a capsule at an early stage. This capsule was formed by multiple layers of flattened fibroblasts separated by small amounts of intercellular material only. The alkaline phosphatase, Mg(2+)-dependent adenosine triphosphatase and 5' nucleotidase reactivities of the follicular dendritic cells in the ileal Peyer's patch were similar to those of early prenatal primary follicles of sheep lymph nodes. This study indicates that the stromal cells of the ileal Peyer's patch are mesenchymal in nature and different from those of germinal centers and the epithelial stromal cells of bursa Fabricii of birds.

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“…Lymphoid follicles of the JPP and colonic patches contain about 35 to 45% sIgM + B lymphocytes, 10 to 15% of CD4 + T lymphocytes and 4 to 6% plasma cells [2,36,43,67]. The percentage of γδ T lymphocytes is markedly higher only in the interfollicular areas of the rectal patches [2].…”

Section: Histology and Lymphocyte Subsetsmentioning

confidence: 99%

“…There is a high frequency of isotype switching. The IPP contains 95% sIgM + B lymphocytes and less than 1% CD4 + T lymphocytes [36,43,67]. More lymphocytes expressing MHCII are present in the IPP compared to JPP [43].…”

Section: Histology and Lymphocyte Subsetsmentioning

confidence: 99%

MALT structure and function in farm animals

2006

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-Mucosa-associated lymphoid tissue (MALT) is defined as an organized lymphoid tissue in the mucosa that samples antigens. The morphological characteristics that distinguish MALT from lymphoid infiltrates are discussed. MALT has been extensively investigated in laboratory animals, while knowledge in cattle, sheep, goats, pigs and horses that are summarized under the term farm animals in this review is fragmentary. Literature data about the distribution, morphology, function and involvement in infectious diseases of MALT in farm animals are described. The understanding of specific features of MALT in other species than laboratory animals is important for comparative research, in order to understand pathological and immunological processes in the respective species and as a potential route of vaccination of mucosal surfaces.

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Distribution of T and B lymphocytes in jejunal and ileocaecal Peyer's patches of lambs

Cited by 34 publications

References 13 publications

Carbonic anhydrase—a marker for particles shed from the epithelium to the lymphoid follicles of the ileal Peyer's patch in goat kids and lambs

Carbonic anhydrase—a marker for particles shed from the epithelium to the lymphoid follicles of the ileal Peyer's patch in goat kids and lambs

Ontogeny of reticular cells in the ileal Peyer's patch of sheep and goats

MALT structure and function in farm animals

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