Distribution of [14C]‐Labelled Aflatoxin B1 in Mice

Arora, Ram Gopal; Appelgren, Lars‐Erik; Bergman, Åke

doi:10.1111/j.1600-0773.1978.tb02265.x

Cited by 30 publications

(4 citation statements)

References 11 publications

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“…Few reports have demonstrated renal damage in rats (Mayura et al, 1998;Abdel-Wahhab, et al, 1998). Arora et al (1978) reported that the kidneys also excreted AFB 1 and that the renal medulla was quite sensitive to this mycotoxin. In our studies, the kidney from rats fed aflatoxin-contaminated diet showed pathological changed typical to those reported in the previous reports and confirmed the changes of the biochemical parameters of kidney functions reported herein.…”

Section: Discussionmentioning

confidence: 99%

Zizyphus spina-Christi Extract Protects Against Aflatoxin B1- Intitiated Hepatic Carcinogenicity

Abdel‐Wahhab

Omara²,

Abdel-Galil³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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Aflatoxins (AF), a group of closely related, extremely toxic mycotoxins, produced by Aspergillus flavus and A. parasiticus can occur as natural contaminants of foods and feeds. Aflatoxins have been shown to be hepatotoxic, carcinogenic, mutagenic, and teratogenic to different animal species. Zizyphus spina-christi L. extract was investigated for its antifungal and antimicrobial activities. The aim of the present work was to evaluate the antioxidant activity of the methanol extract of Z. spina-christi L. leaves against the oxidative stress of aflatoxin in rats. Fourty male Sprague-Dawley male rats were divided into four groups including the control group, the group fed aflatoxin-contaminated diet (3 mg /kg diet) and the groups treated with Zizyphus extract (5 mg /kg b.w) alone or in combination with AF for 15 days. Biochemical analysis reveled that treatment with AF resulted in a significant increase in ALT, AST, cholesterol, triglycerides, uric acid, TNFa, LPO, NO and CEA, whereas it decrease significantly GPX and SOD. The histopatholgical examination of the liver, kidney and testis showed sever histological changes typical to those reported for aflatoxicosis. Animals treated with Zizyphus extract alone or plus AF showed a significant improvement in all biochemical parameters and histological picture of liver, kidney and testis. It could be concluded that Zizyphus extract have a power protective role against aflatoxicosis.

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Section: Discussionmentioning

confidence: 99%

Zizyphus spina-Christi Extract Protects Against Aflatoxin B1- Intitiated Hepatic Carcinogenicity

Abdel‐Wahhab

Omara²,

Abdel-Galil³

et al. 2008

Afr. J. Trad. Compl. Alt. Med.

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“…Wangikar et al[ 106 ], 2014 studied the effect of OTA and aflatoxin B1 (AFB 1 ) mycotoxins administered orally to pregnant rats, revealing that these mycotoxins caused visceral anomalies such as gastroschisis. Arora et al[ 107 ], reported that a single dose of AFB 1 given in a pregnant female by the stomach tube caused protrusion of intestines after exposure on gestation day 8. Treatment of pregnant rats with AFB 1 resulted in the formation of benign and malignant tumors in the liver, stomach, intestine, endocrine organs, and the central and peripheral nervous system in the offspring.…”

Section: Role Of Food Contaminants On Fetal Programmingmentioning

confidence: 99%

Early exposure to food contaminants reshapes maturation of the human brain-gut-microbiota axis

Sarron¹,

Pérot²,

Barbezier³

et al. 2020

WJG

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Early childhood growth and development is conditioned by the consecutive events belonging to perinatal programming. This critical window of life will be very sensitive to any event altering programming of the main body functions. Programming of gut function, which is starting right after conception, relates to a very well-established series of cellular and molecular events associating all types of cells present in this organ, including neurons, endocrine and immune cells. At birth, this machinery continues to settle with the establishment of extra connection between enteric and other systemic systems and is partially under the control of gut microbiota activity, itself being under the densification and the diversification of microorganisms’ population. As thus, any environmental factor interfering on this pre-established program may have a strong incidence on body functions. For all these reasons, pregnant women, fetuses and infants will be particularly susceptible to environmental factors and especially food contaminants. In this review, we will summarize the actual understanding of the consequences of repeated low-level exposure to major food contaminants on gut homeostasis settlement and on brain/gut axis communication considering the pivotal role played by the gut microbiota during the fetal and postnatal stages and the presumed consequences of these food toxicants on the individuals especially in relation with the risks of developing later in life non-communicable chronic diseases.

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“…It is also the most prevalent aflatoxin usually found in cases of aflatoxicosis and is responsible for acute toxicity, chronic toxicity, carcinogenicity, teratogenicity, genotoxicity and immunotoxicity (Creppy, 2002). Several reports have shown the detrimental effects of AFB1 on the liver (Hassan et al, 2015), testis, epididymis (Agnes and Akbarsha, 2001;Hamzawy et al, 2012), Kidney (Abdel-Hamid andFirgany Ael, 2015;Arora et al, 1978), Heart (Abdulmajeed, 2011;Mohamed and Metwally, 2009), ovary (Ibeh et al, 2000), and the brain (Bahey et al, 2015). Aflatoxin B1 mutagenic effects have been well documented in a number of in vitro and in vivo models, where the presence of DNA adducts, DNA breaks, gene mutations, induction of DNA synthesis and inhibition of DNA repair have been determined, as well as increases in the rate of chromosomal aberrations, micronuclei and sister chromatid exchanges (SCE) (Madrigal-Santillán, et al, 2010;Witt et al, 2000;Woo et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

The Effects of Aflatoxin B1 on Chromosome Aberrations and Sister Chromatid Exchanges in Human Lymphocytes

Algarni¹

2018

Int. J. Curr. Res. Biosci. Plant Biol.

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Aflatoxin B1 (AFB1) is a ubiquitous mycotoxin produced by toxicogenic Aspergillus species. AFB1 has been reported to cause serious adverse health effects, such as cancers and abnormal development and reproduction, in animals and humans. The aim of this study was to investigate the ability of aflatoxin B1 (AFB1) to induce chromosome aberrations (CA) and sister chromatid exchanges (SCE) in human lymphocytes. AFB1 exposure significantly increased the number of CA and the frequency of SCE when compared with the control group. This significant increase in CAs as well as SCE may be attributed to the fact that AFB1 can induce genotoxicity through DNA damage. Thus, the present study indicates that AFB1 was genotoxic in human lymphocytes. K e y w o r d s Aflatoxin B1 Chromosome aberrations Genotoxicity Human lymphocytesHow to cite this article:

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Distribution of [¹⁴C]‐Labelled Aflatoxin B₁ in Mice

Cited by 30 publications

References 11 publications

<i>Zizyphus spina-Christi</i> Extract Protects Against Aflatoxin B1- Intitiated Hepatic Carcinogenicity

<i>Zizyphus spina-Christi</i> Extract Protects Against Aflatoxin B1- Intitiated Hepatic Carcinogenicity

Early exposure to food contaminants reshapes maturation of the human brain-gut-microbiota axis

The Effects of Aflatoxin B1 on Chromosome Aberrations and Sister Chromatid Exchanges in Human Lymphocytes

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