Distribution of substance P-like immunoreactivity in guinea pig central nervous system

Gallagher, Anna; Chahl, Loris A.; Lynch, A.M.

doi:10.1016/0361-9230(92)90027-u

Cited by 28 publications

(8 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…SP immunostaining in the female guinea pig midbrain appears to be similar to that previously reported in guinea pigs [38] and rats [33]. SP immunoreactivity was present in varying densities throughout the rostrocaudal extent of the MCG and overlapped with the distribution of ERIR at all MCG levels.…”

Section: Discussionsupporting

confidence: 67%

Convergence of Substance P and Estrogen Receptor Immunoreactivity in the Midbrain Central Gray of Female Guinea Pigs

Turcotte

Blaustein²

1997

Neuroendocrinology

View full text Add to dashboard Cite

Substance P (SP) and estrogen receptor immunoreactivity overlap in the mid-brain central gray (MCG) of female guinea pigs. Estrogen-receptor-containing cells are found throughout the rostrocaudal extent of the MCG. Moderately dense SP immunostaining is also found in this region. SP-immunoreactive punctate structures suggestive of boutons were found in close association with the processes of some estrogen-receptor-immunoreactive neurons. These associations were observed primarily in the lateral and ventrolateral MCG at the midcollicular and caudal levels. This finding suggests an anatomical substrate for interactions between SP and estradiol-sensitive neurons in the midbrain. Such interactions may underlie the effects of SP on female sexual behavior.

show abstract

Section: Discussionsupporting

confidence: 67%

Convergence of Substance P and Estrogen Receptor Immunoreactivity in the Midbrain Central Gray of Female Guinea Pigs

Turcotte

Blaustein²

1997

Neuroendocrinology

View full text Add to dashboard Cite

show abstract

“…Even following pretreatment with colchicine, cell bodies containing SP-IR are not found within the SCN of A. niloticus (present study), mice (Stoekel et al, 1982), ground squirrels (Smale et al, 1991), guinea pigs (Gallagher et al, 1992), or mice (Stoeckel et al, 1982); SP-IR is also absent from cell bodies within the SCN of sheep (Tillet et al, 1989). On the other hand, SP-IR cell bodies are present in a distinct subnucleus within the SCN of both golden hamsters (M. auratus, Morin et al, 1991) and djungarian hamsters (Phodopus sungoris, Reuss and Burger, 1994).…”

Section: Suprachiasmatic Nucleusmentioning

confidence: 44%

“…In the case of some peptides, this variability does not follow clear phylogenetic patterns. For example, SP-IR is found within neurons in the SCN of a primate (Mick et al, 1992) and the golden hamster , but not A. niloticus (present study) or guinea pigs (Gallagher et al, 1992). This variability suggests that this peptide has been lost and/or gained from SCN neurons at multiple points in mammalian evolution.…”

Section: General Conclusionmentioning

confidence: 69%

The suprachiasmatic nucleus and intergeniculate leaflet ofArvicanthis niloticus, a diurnal murid rodent from East Africa

Smale

Boverhof

1999

J. Comp. Neurol.

View full text Add to dashboard Cite

“…This difference in the detection of SP-positive hippocampal cells between different avian species is paralleled in mammals. Some mammalian species, including humans, monkeys, and guinea pigs, exhibit SP-immunoreactive cell bodies in the Hp (Del Fiacco et al, 1987;Gallagher et al, 1992;Seress and Leranth, 1996), but, in the rat, these are not seen in the absence of colchicine pretreatment (Borhegyi and Leranth, 1997b). Of course, the level of SP in hippocampal cell bodies in rats may be below the threshold for detection by immunohistochemistry, and this could also be true in those avian species studied in which SP-immunoreactive cell bodies have not been found.…”

Section: Quantitative Comparisonsmentioning

confidence: 97%

Distribution of substance P reveals a novel subdivision in the hippocampus of parasitic South American cowbirds

Nair-Roberts

Erichsen

Reboreda

et al. 2006

J of Comparative Neurology

View full text Add to dashboard Cite

Parasitic cowbirds monitor potential hosts' nests and return to lay when appropriate, a task that is likely to involve spatial recall. Seasonal and sexual behavioral variations in the cowbirds correlate with anatomical changes in the hippocampal formation. During the breeding season, parasites have larger hippocampal formations than nonparasites. In parasitic species in which females alone perform nest bookkeeping, females have larger hippocampal formations than males. We investigated the distribution of the neuropeptide substance P (SP) in three sympatric cowbirds: two obligate parasites (shiny cowbird and screaming cowbird) and one nonparasite (bay-winged cowbird). Distribution of SP was similar to that in other songbirds, except for a previously undescribed field of dense SP-rich terminals within the hippocampus that we call the hippocampal SP terminal field (SPh). We found robust species differences in the volume of this new area, measured relative to the remainder of the telencephalon. SPh was largest in the generalist parasite (shiny cowbird) and smallest in the nonparasitic species (bay-winged cowbird). In the specialist parasite (screaming cowbird), SPh was smaller than in the generalist parasite but larger than in the nonparasitic species. SPh overlaps with two subdivisions described in the pigeon that have been related to the mammalian dentate gyrus and subiculum. The area containing SPh receives a major input from the lateral mammillary nucleus, which is probably the avian equivalent of the mammalian supramammillary nucleus (SUM), the main source of extrinsic SP input to mammalian hippocampus. SPh may be the termination of a pathway homologous to the SP-rich projection from SUM to the hippocampus in mammals.

show abstract

Distribution of substance P-like immunoreactivity in guinea pig central nervous system

Cited by 28 publications

References 36 publications

Convergence of Substance P and Estrogen Receptor Immunoreactivity in the Midbrain Central Gray of Female Guinea Pigs

Convergence of Substance P and Estrogen Receptor Immunoreactivity in the Midbrain Central Gray of Female Guinea Pigs

The suprachiasmatic nucleus and intergeniculate leaflet ofArvicanthis niloticus, a diurnal murid rodent from East Africa

Distribution of substance P reveals a novel subdivision in the hippocampus of parasitic South American cowbirds

Contact Info

Product

Resources

About