Distribution of Subsequent Primary Invasive Melanomas Following a First Primary Invasive or In Situ Melanoma in Queensland, Australia, 1982-2010

Youlden, Danny R.; Youl, Philippa; Soyer, H. Peter; Aitken, Joanne F.; Baade, Peter D.

doi:10.1001/jamadermatol.2013.9852

Cited by 70 publications

(72 citation statements)

References 27 publications

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“…Second, OCR registers only the first incident melanoma diagnosis for a given patient. This method of dealing with multiple primary tumors is particularly problematic for melanoma, given that 3-9 % of patients develop a second primary melanoma [21][22][23][24], and that previous melanoma is an independent risk factor for a subsequent primary melanoma [25][26][27]. For patients with multiple primary melanomas whose first melanoma diagnosis preceded the LifeLabs pathology report, the LifeLabs report would not have been registered as a distinct melanoma diagnosis in OCR.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive capture of cutaneous melanoma by the Ontario Cancer Registry: validation study using community pathology reports

Tran

Schwartz

Fung

et al. 2015

Cancer Causes Control

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Melanoma is often managed outside hospital settings, creating the potential for underreporting to cancer registries. To our knowledge, completeness of melanoma capture in cancer registries has not been assessed using external data sources since the 1980s. We evaluated the melanoma capture rate from 1993 to 2009 in a provincial cancer registry. We identified all melanoma diagnoses in pathology reports from a major community laboratory in Ontario, Canada. Pathologically confirmed diagnoses were linked to Ontario Cancer Registry (OCR) records using health insurance numbers. We calculated capture rates as the proportion of patients with melanoma confirmed by a pathology report, with a corresponding melanoma diagnosis in OCR. OCR captured 3,798 of 4,275 (88.8, 95 % confidence interval: 87.9, 89.8 %) invasive melanoma diagnoses over the 17-year period. Annual capture rates of 94 % or higher were found for over half the study period. Among all 29,133 melanoma diagnoses in OCR, 27.6 % were registered based on a pathology report alone, compared with 3.4 % for non-cutaneous malignancies. This suggests that comprehensive capture of melanoma cases by a provincial cancer registry is achievable using source data from community laboratories. There is a need for ongoing validation to ensure data remain accurate and complete to reliably inform clinical care, research, and policy.

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Section: Discussionmentioning

confidence: 99%

Comprehensive capture of cutaneous melanoma by the Ontario Cancer Registry: validation study using community pathology reports

Tran

Schwartz

Fung

et al. 2015

Cancer Causes Control

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“…Multiple primary melanomas (MPM) are diagnosed in 1.2% to 8.2% of patients with sporadic melanoma . Patients with melanoma are at approximately nine‐fold increased risk of developing an additional primary melanoma compared to the general population . The risk is higher within the first year but remains elevated for more than 20 years after first diagnosis supporting a continued long‐term surveillance in melanoma patients …”

Section: Introductionmentioning

confidence: 99%

Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomas

Moscarella

Pellegrini

Pampena

et al. 2019

Experimental Dermatology

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Background The association of clinical and dermoscopic features with BRAF mutational status has been poorly analysed in multiple primary melanomas (MPM). Objective To investigate whether concordance of BRAF mutational status is associated with dermoscopic similarity in multiple melanomas of the same patient. Methods Dermoscopic images and corresponding tissue sections of 124 melanomas from 62 patients with MPM were selected at four Italian Dermatology Departments. Similarity of dermoscopic appearance between multiple melanomas was evaluated according to the presence of the same prevalent dermoscopic feature. The BRAFV600 mutational status was analysed with allele‐specific TaqManTM assays or pyrosequencing. Spearman's correlation and univariate and multivariate regression analysis were used for statistical analysis. Results A similar dermoscopic appearance was identified in 38.7% (24/62) of patients with MPM and was correlated with older age at first diagnosis (rho: 0.26; P: 0.042) and occurrence on sun‐damaged skin (rho: 0.27; P: 0.037). The BRAFV600 mutation was detected in 39.5% (49/124) of the tumors and a concordant BRAF mutational status between melanomas in 33/62 (53.2%) MPM patients. Dermoscopically similar melanomas showed 5.7‐fold higher odds to be concordant for BRAF mutational status compared to dissimilar lesions (OR: 5.7; 95% CI 1.7‐19.5; P: 0.005). Conclusion Dermoscopic similarity of multiple melanomas represents an independent clinical predictor of a concordant BRAF mutational status in MPM patients.

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“…The guidelines recommended that patients classified as high risk should be encouraged to perform skin self-examination, be educated about specific changes that suggest melanoma, and be offered a skin surveillance program. This advice is particularly relevant to people already diagnosed with melanoma, who are at 5-to 10-fold increased risk of a subsequent primary melanoma (11,12). Targeted high-risk screening and surveillance programs have been shown to assist with early diagnosis of melanoma and are deemed more cost-effective than a population-wide screening program (13)(14)(15)).…”

Section: Introductionmentioning

confidence: 99%

Doctors’ recognition and management of melanoma patients’ risk: An Australian population-based study

Madronio

Armstrong

Watts

et al. 2016

Cancer Epidemiology

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Distribution of Subsequent Primary Invasive Melanomas Following a First Primary Invasive or In Situ Melanoma in Queensland, Australia, 1982-2010

Cited by 70 publications

References 27 publications

Comprehensive capture of cutaneous melanoma by the Ontario Cancer Registry: validation study using community pathology reports

Comprehensive capture of cutaneous melanoma by the Ontario Cancer Registry: validation study using community pathology reports

Dermoscopic similarity is an independent predictor of BRAF mutational concordance in multiple melanomas

Doctors’ recognition and management of melanoma patients’ risk: An Australian population-based study

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