Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients

Misaki, Taro; Naka, Shuhei; Kuroda, Keiko; Nomura, Ryota; Shiooka, Tempei; Naito, Yasuhisa; Suzuki, Yumiko; Yasuda, Hideo; Isozaki, Taisuke; Nakano, Kazuhiko

doi:10.1007/s10157-014-1072-0

Cited by 29 publications

(26 citation statements)

References 26 publications

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“…Thus, we hypothesized that the presence of cnm -positive S. mutans strains may affect IgAN. We previously showed that the rate of cnm -positive S. mutans strains isolated from the oral cavity was found to be significantly higher in IgAN patients than in non-diseased controls, suggesting that the presence of cnm -positive S. mutans strains in the oral cavity may influence IgAN severity18. Based upon the present study, we hypothesized that cnm status and dental caries status exacerbate urinary protein levels in IgAN patients.…”

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confidence: 50%

Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions

Misaki

Naka

Hatakeyama

et al. 2016

Sci Rep

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Streptococcus mutans is a major pathogen of human dental caries. Strains harbouring the cnm gene, which encodes Cnm, a collagen-binding protein, contribute to the development of several systemic diseases. In this study, we analysed S. mutans strains isolated from the oral cavity of immunoglobulin (Ig)A nephropathy (IgAN) patients to determine potential relationships between cnm and caries status as well as IgAN conditions. Saliva specimens were collected from 109 IgAN patients and the cnm status of isolated S. mutans strains was determined using PCR. In addition, the dental caries status (decayed, missing or filled teeth [DMFT] index) in patients who agreed to dental consultation (n = 49) was evaluated. The DMFT index and urinary protein levels in the cnm-positive group were significantly higher than those in the cnm-negative group (p < 0.05). Moreover, the urinary protein levels in the high DMFT (≥15) group were significantly higher than those in the low DMFT (<15) group (p < 0.05). Our results show that isolation of cnm-positive S. mutans strains from the oral cavity may be associated with urinary protein levels in IgAN patients, especially those with a high dental caries status.

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confidence: 50%

Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions

Misaki

Naka

Hatakeyama

et al. 2016

Sci Rep

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“…Our recent studies suggest that cnm -positive S. mutans strains could be associated with aggravated cerebral haemorrhaging [16-18], non-alcoholic steatohepatitis [19, 20] and inflammatory bowel disease [21]. We also demonstrated that cnm -positive S. mutans was associated with IgAN [22, 23]. …”

Section: Introductionmentioning

confidence: 60%

“…No differences were observed among the 2 groups in the mesangial hypercellularity, endocapillary hypercellularity, segmental glomerulosclerosis, tubular atrophy/interstitial fibrosis and crescent scores (Table 3). Comparisons between cnm -positive and -negative S. mutans groups of IgAN patients were described in detail previously [22]. The segmental glomerulosclerosis score was significantly higher in the cnm -positive group than in the cnm -negative group (0.94 vs. 0.57, p = 0.02) [22].…”

Section: Resultsmentioning

confidence: 99%

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<b><i>Campylobacter rectus</i></b> in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients

Misaki

Naka

Wato

et al. 2018

Nephron

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Background: Periodontitis-related pathogens, such as Campylobacter or Treponema species, have recently been shown to be associated with immunoglobulin A nephropathy (IgAN). Some strains of Streptococcus mutans, a major pathogen of dental caries, harbour the cnm gene that encodes a collagen-binding protein (Cnm). This has also been demonstrated to be associated with urinary protein levels in IgAN patients. Objectives: The purpose of the present study was to analyse the association of IgAN with C. rectus, Treponema denticola and cnm-positive S. mutans in the oral cavity of humans. Methods: The presence of C. rectus, T. denticola and cnm-positive S. mutans strains in saliva samples of 117 IgAN patients and 56 healthy controls was evaluated by PCR, and the subjects’ clinical parameters were analysed. Results: C. rectus was significantly more prevalent in the IgAN group than in the control group (p < 0.05). The C. rectus-positive group was significantly associated with proteinuria in the IgAN group (p < 0.05). In addition, the C. rectus-positive and cnm-positive S. mutans group was shown to be more closely associated with urinary protein levels than the other groups (p < 0.0083). Conclusion: Our results suggest that harbouring C. rectus in the oral cavity could be associated with proteinuria in IgAN patients.

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“…Oral bacteria can enter the bloodstream, and usually, bacteremia can be rapidly eliminated by the immune system. However, it has been shown that if S. mutans persists in the bloodstream, it can colonize the endothelial cells of the coronary arteries [36]; the cerebral arterial wall [51], the renal arterial wall [52], and even reach the hepatic veins in the liver [53]. G. mellonella has a pathogenic defense mechanism similar to the innate immune system of mammals [54], and their hemolymph is considered an analog to blood in vertebrates.…”

Section: Discussionmentioning

confidence: 99%

Inactivation ofStreptococcus mutansgeneslytSTanddltADimpairs its pathogenicityin vivo

Pedraza

Rosalen

Castilho

et al. 2019

Journal of Oral Microbiology

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Background: Streptococcus mutans orchestrates the development of a biofilm that causes dental caries in the presence of dietary sucrose, and, in the bloodstream, S. mutans can cause systemic infections. The development of a cariogenic biofilm is dependent on the formation of an extracellular matrix rich in exopolysaccharides, which contains extracellular DNA (eDNA) and lipoteichoic acids (LTAs). While the exopolysaccharides are virulence markers, the involvement of genes linked to eDNA and LTAs metabolism in the pathogenicity of S. mutans remains unclear. Objective and Design: In this study, a parental strain S. mutans UA159 and derivative strains carrying single gene deletions were used to investigate the role of eDNA (ΔlytS and ΔlytT), LTA (ΔdltA and ΔdltD), and insoluble exopolysaccharides (ΔgtfB) in virulence in a rodent model of dental caries (rats) and a systemic infection model (Galleria mellonella larvae). Results: Fewer carious lesions were observed on smooth and sulcal surfaces of enamel and dentin of the rats infected with ΔlytS, ΔdltD, and ΔgtfB (vs. the parental strain). Moreover, strains carrying gene deletions prevented the killing of larvae (vs. the parental strain). Conclusions: Altogether, these findings indicate that inactivation of lytST and dltAD impaired S. mutans cariogenicity and virulence in vivo.

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Distribution of Streptococcus mutans strains with collagen-binding proteins in the oral cavity of IgA nephropathy patients

Abstract: cnm-positive S. mutans strains are potentially associated with the pathogenesis of IgAN.

Cited by 29 publications

References 26 publications

Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions

Presence of Streptococcus mutans strains harbouring the cnm gene correlates with dental caries status and IgA nephropathy conditions

<b><i>Campylobacter rectus</i></b> in the Oral Cavity Correlates with Proteinuria in Immunoglobulin A Nephropathy Patients

Inactivation ofStreptococcus mutansgeneslytSTanddltADimpairs its pathogenicityin vivo

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