Distribution of serum zinc levels in hemodialysis patients–factors related to hypozincemia–

Nagano, Nobuo; Ito, Kyoko; Oishi, Yo; Minami, Masami; Hayashi, Hideki; Tsunoda, Chie; Nakajima, Haruno; Sunaga, Satoru; Nohara, Tomoi; Otaka, Yukihiro; Hoshi, Ayako; Tamei, Noriko; Nohara, Atsushi; Ando, Tetsuo; Ogawa, Tetsuya; Nitta, Kosaku; Tsutsui, Takaaki

doi:10.4009/jsdt.51.369

Cited by 3 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Zinc intake is insufficient in 60-70% of both males and females aged ≥ 20 years and is significantly lower than the RDA in pregnant and lactating women as well ( Figure 2) [4,5]. Zinc deficiency is known often to accompany severe physical disabilities, liver cirrhosis, chronic hepatitis, chronic inflammatory bowel diseases, type 2 diabetes mellitus, chronic kidney disease, cardiac insufficiency, short stature, and is also more common in the elderly and professional athletes [6][7][8][9][10][11][12][13][14][15]. Percentage of people with zinc intake less than the RDA in Japan.…”

Section: Prevalence Of Insufficient Zinc Intake and Zinc Deficiency Imentioning

confidence: 99%

“…Finally, excessive excretion of zinc via urine can cause zinc deficiency. Excessive excretion occurs in those with conditions such as chronic kidney disease [12,13] and diabetes mellitus [11]. Table 1 summarizes the four criteria in the Practical Guideline for diagnosing zinc deficiency.…”

Section: Causes Of Zinc Deficiency Can Be Divided Into Four Major Catmentioning

confidence: 99%

“…Zinc is administered to patients suffering from a wide variety of diseases, including chronic liver disease, cirrhosis, IBD, chronic kidney disease [12,13], and diabetes mellitus [11]. It is also administered to those taking medications with chelating effects, and to athletes and pregnant women.…”

Section: Treatment Of Zinc Deficiencymentioning

confidence: 99%

See 2 more Smart Citations

Japan’s Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis

Kodama

Tanaka

Naito

et al. 2020

IJMS

View full text Add to dashboard Cite

Zinc deficiency is common in Japan, yet awareness on this disorder is lacking. The Japanese Society of Clinical Nutrition recently issued the Japan’s Practical Guideline for Zinc Deficiency 2018 setting forth criteria for diagnosing zinc deficiency, i.e., (a) one or more symptoms of zinc deficiency or low serum alkaline phosphatase, (b) ruling out other diseases, (c) low serum zinc, and (d) alleviation of symptoms upon zinc administration. Serum zinc <60 μg/dL and 60–80 μg/dL indicate zinc deficiency and marginal deficiency, respectively. Zinc deficiency symptoms vary and include dermatitis and taste disorders among others. Zinc administration improves taste in 50–82% of patients suffering from taste disorders (a common symptom of zinc deficiency). Effects of zinc administration do not appear immediately, and therapy should be continued for at least three months. Zinc deficiency often accompanies various diseases and conditions. Here, we focus on inflammatory bowel diseases and liver cirrhosis. As zinc deficiency enhances intestinal inflammation via macrophage activation, we discuss the pathological mechanism for inflammation and zinc deficiency in the context of IBD. Zinc deficiency can also lead to a nitrogen metabolic disorder in patients with liver cirrhosis. Zinc supplementation can improve not only the ammonia metabolism, but also the protein metabolism. We also discuss directions for future studies of zinc deficiency.

show abstract

Section: Prevalence Of Insufficient Zinc Intake and Zinc Deficiency Imentioning

confidence: 99%

Section: Causes Of Zinc Deficiency Can Be Divided Into Four Major Catmentioning

confidence: 99%

See 1 more Smart Citation

Japan’s Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis

Kodama

Tanaka

Naito

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…It has been reported so far that the prevalence rate of zinc deficiency among patients undergoing hemodialysis (HD) was high at 40%-78% [7][8][9]; the prevalence rates of zinc deficiency (Zn<60 μg/dL) and marginal zinc deficiency (60-80 μg/dL) in HD patients in Japan were 51.0% and 44.4%, respectively [10]. Thus, approximately 95% of HD patients in Japan meet the definition of zinc deficiency [10].…”

Section: Introductionmentioning

confidence: 99%

Association between zinc deficiency and aorta stiffness in non-diabetic hemodialysis patients

et al. 2023

View full text Add to dashboard Cite

Objectives Zinc deficiency (Zn < 60 μg/dL) is known to play an important role for vascular calcification. However, little data is available regarding the association between zinc deficiency and aorta stiffness in dialysis patients. Thus, we studied the relationship between zinc deficiency and aorta stiffness in non-diabetic hemodialysis (HD) patients. Methods Of 150 patients receiving maintenance HD at our hospital, we included 79 non-diabetic HD patients (age: 70±11 years, 49 men) after excluding 71 diabetic HD patients. Zinc deficiency was defined as Zn <60 μg/dL during pre-HD blood sampling. The association between zinc deficiency and aorta stiffness was analyzed. Aorta stiffness was evaluated as brachial-ankle pulse wave velocity (baPWV). Other surrogate markers for cardiovascular complications were also measured. Results The zinc deficiency group (ZD group) included 45 patients (57.0%). Compared to the zinc non-deficiency group (ZND group), patients with ZD group were significantly older, higher levels of CRP and hypoalbuminemia. Moreover, they had significantly higher levels of baPWV, and lower levels of ankle-brachial pressure index (ABI) (p<0.05). After adjusting for hypoalbuminemia, and CRP, multivariate analysis showed that age and zinc level were independent predictors of baPWV. Conclusion The study suggested that zinc deficiency may be an independent risk factor for aorta stiffness, even after adjusting for malnutrition and inflammation.

show abstract

“…It has benn reported so far that the zinc deficiency among patients undergoing hemodialysis (HD) was high at 40%–78% 7)8)9); the rates of zinc deficiency (Zn<60 μg/dL) and marginal zinc deficiency (60–80 μg/dL) in HD patients in Japan were 51.0% and 44.4%, respectively10). Thus, approximately 95% of HD patients in Japan satisfy the standard value of zinc deficiency10).…”

Section: Introductionmentioning

confidence: 99%

Association between zinc deficiency and aorta stiffness in non-diabetic hemodialysis patients

Ishioka

Hidaka

Fujiwara

et al. 2022

Preprint

View full text Add to dashboard Cite

ObjectivesZinc deficiency (Zn < 60 μg/dL) is known to play an important role for vascular calcification. However, little data is available regarding the association between zinc deficiency and aorta stiffness in dialysis patients. Thus, we studied the relationship between zinc deficiency and aorta stiffness in non-diabetic hemodialysis(HD) patients.MethodsOf 150 patients receiving maintenance HD at our hospital, we included 79 non-diabetic HD patients (age: 70±11 years, 49 men) after excluding 71 diabetic HD patients. Zinc deficiency was defined as Zn <60 μg/dL during pre-HD blood sampling. The association between zinc deficiency and aorta stiffness was analyzed. Aorta stiffness was evaluated as brachial-ankle pulse wave velocity (baPWV). Other surrogate markers for cardiovascular complications were also measured.ResultsThe zinc deficiency group (ZD group) included 45 patients (57.0%). Compared to the zinc non-deficiency group (ZND group), patients with ZD group were significantly older, higher levels of CRP and hypoalbuminemia. Moreover, they had significantly higher levels of baPWV, and lower levels of ankle-brachial pressure index (ABI) (p<0.05). After adjusting for hypoalubuminuria, and CRP, multivariate analysis showed that age and zinc level were independent predictors of baPWV.ConclusionThe study suggested that zinc deficiency may be an independent risk factor for aorta stiffness, even after adjusting for malnutrition and inflammation.

show abstract

Distribution of serum zinc levels in hemodialysis patients–factors related to hypozincemia–

Cited by 3 publications

References 7 publications

Japan’s Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis

Japan’s Practical Guidelines for Zinc Deficiency with a Particular Focus on Taste Disorders, Inflammatory Bowel Disease, and Liver Cirrhosis

Association between zinc deficiency and aorta stiffness in non-diabetic hemodialysis patients

Association between zinc deficiency and aorta stiffness in non-diabetic hemodialysis patients

Contact Info

Product

Resources

About