Distribution of Satb1 in the central nervous system of adult mice

Huang, Ying; Zhang, Lei; Song, Ning‐Ning; Hu, Zheyi; Chen, Jia-Yin; Ding, Yu

doi:10.1016/j.neures.2011.05.015

Cited by 23 publications

(26 citation statements)

References 32 publications

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“…At later stages (P2), SATB1 + interneurons were absent from the MZ and IZ/SVZ but were abundant within the cortex (Figures 2E–2F2). Finally, and in agreement with previous reports (Huang et al., 2011; Balamotis et al., 2012), Satb1 was also expressed by pyramidal neurons (Figures 1A–1A2 and 2E–2F2). By demonstrating that during cortical development Satb1 is expressed by an increasing number of MGE-derived GABAergic neurons, our results suggest that SATB1 is implicated in the terminal differentiation and maturation of cortical interneurons.…”

Section: Resultssupporting

confidence: 94%

Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons

Denaxa¹,

Kalaitzidou²,

Garefalaki³

et al. 2012

Cell Reports

105

125

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SummaryThe generation of cortical interneuron subtypes is controlled by genetic programs that are activated in the ventral forebrain and unfold during the prolonged period of inhibitory neuron development. The LIM-homeodomain protein LHX6 is critical for the development of all cortical interneurons originating in the medial ganglionic eminence, but the molecular mechanisms that operate downstream of LHX6 to control the terminal differentiation of somatostatin- and parvalbumin-expressing interneurons within the cortex remain unknown. Here, we provide evidence that the nuclear matrix and genome organizer protein SATB1 is induced by neuronal activity and functions downstream of Lhx6 to control the transition of tangentially migrating immature interneurons into the terminally differentiated Somatostatin (SST)-expressing subtype. Our experiments provide a molecular framework for understanding the genetic and epigenetic mechanisms by which specified but immature cortical interneurons acquire the subtype-defining molecular and morphophysiological characteristics that allow them to integrate and function within cortical circuits.

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Section: Resultssupporting

confidence: 94%

Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons

Denaxa¹,

Kalaitzidou²,

Garefalaki³

et al. 2012

Cell Reports

105

125

View full text Add to dashboard Cite

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“…B‐B″,C‐C″). Therefore, Satb2 is expressed exclusively in neurons, similar to the distribution of Satb1 in a previous report (Huang et al, ). To explore whether Satb2 is expressed in excitatory or inhibitory neurons, double immunostaining for Satb2 and GFP was performed in brain sections from GAD67‐GFP knock‐in mice (Tamamaki et al, ), in which GFP expression is driven by the promoter of GABA‐synthesizing enzyme GAD67.…”

Section: Resultssupporting

confidence: 88%

“…Although Satb2 expression was not observed in the VTA and SNc, which contains the midbrain dopaminergic neurons projecting widely to the brain, the majority of TH‐positive neurons are expressing Satb1 in these two brain regions (Huang et al, ). Conversely, Satb1‐positive neurons in the dorsal raphe nucleus are not serotonergic (Huang et al, ), wheareas the majority of Satb2‐positive neurons was found to be colocalized with Tph2 in the dorsal part of this nucleus. The differential distribution of these two family members suggests their separate, not redundant, roles in the brain.…”

Section: Discussionmentioning

confidence: 99%

Expression of Transcription Factor Satb2 in Adult Mouse Brain

Huang

Song

Lan

et al. 2013

The Anatomical Record

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Previous investigations on the expression and function of special AT-rich sequence binding protein 2 (Satb2) are largely limited to the cerebral cortex. Here, we explore the expression of Satb2 thoroughly by immunohistochemistry in the adult mouse central nervous system (CNS). Besides the cerebral cortex, we found that Satb2 is specifically expressed in the bed nucleus of the stria terminalis, horizontal limb of the diagonal band, lateral hypothalamic area, arcuate nucleus, hypothalamic paraventricular nucleus, ventral tegmental nucleus, laterodorsal tegmental nucleus, dorsal raphe nucleus, rostral periolivary region, and parabrachial nucleus. Double immunostaining showed that Satb2 is exclusively expressed in the excitatory neurons of neocortex. In addition, Satb2 is specifically expressed in A12 group of hypothalamic dopaminergic neurons and in serotonergic neurons in the dorsal part of the dorsal raphe nucleus. Our results present a comprehensive overview of Satb2 expression in the adult brain and provide insights for studying the role of Satb2 in the mature CNS. Anat Rec, 296:452-461,

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“…[3][4][5] Special AT-rich sequence binding protein 1 (SATB1) is a nuclear matrix attachment DNA-binding protein, which is predominantly expressed in thymocytes and central nervous system. 6,7 SATB1, generally acknowledged as a genome organizer, tethers multiple genomic loci and recruits chromatin-remodeling enzymes to regulate the chromatin structure and gene expression. 8 Aberrant expression of SATB1 has been shown to play an important role in the initiation and progression of breast cancer, 9,10 lymphoma, 11 gastric cancer, 12 and various other cancers.…”

Section: Introductionmentioning

confidence: 99%

Inhibition of SATB1 by shRNA Suppresses the Proliferation of Cutaneous Malignant Melanoma

Zhang

Fang

et al. 2014

Cancer Biotherapy and Radiopharmaceuticals

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Overexpression of special AT-rich sequence binding protein 1 (SATB1), a global genome organizer, as a predictor of poor prognosis in cutaneous malignant melanoma (CMM) attracted great interest in previous research. In this article, upregulated SATB1 was observed in three melanoma cell lines and in eight CMM tissues. After downregulating SATB1 by RNAi, proliferation of A375 was suppressed in vitro and in vivo. In summary, the proliferation of CMM could be related closely to the SATB1 gene. Interference of this gene may be a promising method for CMM therapy.

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Distribution of Satb1 in the central nervous system of adult mice

Cited by 23 publications

References 32 publications

Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons

Maturation-Promoting Activity of SATB1 in MGE-Derived Cortical Interneurons

Expression of Transcription Factor Satb2 in Adult Mouse Brain

Inhibition of SATB1 by shRNA Suppresses the Proliferation of Cutaneous Malignant Melanoma

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