Distribution of rodenticide resistance and zoonotic pathogens in Norway rats in Lower Saxony and Hamburg, Germany

Runge, Martin; Keyserlingk, Michael von; Braune, S.; Becker, Detlef; Plenge‐Bönig, Anita; Freise, Jona; Pelz, Hans-Joachim; Esther, Alexandra

doi:10.1002/ps.3369

Cited by 40 publications

(30 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The occurrence of the Tyr139Cys genotype (German) seems to be more widespread, probably because this genotype was present earlier in the country compared with the Tyr139Phe genotype (French/Belgian). This seems to be similar to the situation in Germany, where the Tyr139Phe genotype has been encountered in one location, whereas the Tyr139Cys mutation seems to be widely distributed throughout north‐western Germany …”

Section: Discussionsupporting

confidence: 79%

See 1 more Smart Citation

Distribution of anticoagulant rodenticide resistance inRattus norvegicusin the Netherlands according toVkorc1mutations

et al. 2014

View full text Add to dashboard Cite

BACKGROUNDRodenticide resistance to anticoagulants in Rattus norvegicus will lead to increased difficulties in combating these pest animals. Here, the authors present the results of a survey in the Netherlands where tissue samples and droppings were tested using a newly developed TaqMan PCR test for genotypic variation at codon 139 in the Vkorc1 gene associated with anticoagulant rodenticide resistance. Test results are linked to results of a questionnaire that was conducted among pest controllers.RESULTSGenetic mutations at codon 139 of the Vkorc1 gene in R. norvegicus can be encountered in many parts of the Netherlands. In 34/61 rat tails, a genotype was found that is linked to anticoagulant rodenticide resistance (56%). In droppings, 42/169 samples (25%) showed a resistance-mediating genotype. In addition, indications of a clear genetic substructure in the Netherlands were found. In some regions, only resistance-mediating genotypes were found, corroborating results from the questionnaire in which pest controllers indicated they suspected resistance to anticoagulant rodenticides.CONCLUSIONThis is the first study to demonstrate the presence of multiple genetic mutations at codon 139 of the Vkorc1 gene in R. norvegicus in the Netherlands. As rodenticides should keep their efficacy because they are a last resort in rodent management, more studies are urgently needed that link specific genetic mutations to the efficacy of active substances. © 2014 Society of Chemical Industry

show abstract

Section: Discussionsupporting

confidence: 79%

“…Moreover, it is assumed that the regions in which resistant R. norvegicus are found are expanding in the Netherlands, as has already happened in Germany . Figure shows that rats with either the Tyr139Cys or the Tyr139Phe genotype can be encountered in a significant part of the Netherlands.…”

Section: Discussionmentioning

confidence: 99%

Distribution of anticoagulant rodenticide resistance inRattus norvegicusin the Netherlands according toVkorc1mutations

et al. 2014

View full text Add to dashboard Cite

show abstract

“…in different rat species. In Germany, Runge et al [30] found leptospiral DNA in 21% of the examined Norway rats ( Rattus norvegicus ), and in France, leptospiral renal carriage was shown in 34.7% of the studied Norway rats [31]. In Poland, renal carriage in Norway rats and black rats ( Rattus rattus ) ranged between 2 and 40%, depending on the region [32].…”

Section: Discussionmentioning

confidence: 99%

Leptospira spp. in Rodents and Shrews in Germany

Mayer‐Scholl

Hammerl

Schmidt

et al. 2014

IJERPH

View full text Add to dashboard Cite

Leptospirosis is an acute, febrile disease occurring in humans and animals worldwide. Leptospira spp. are usually transmitted through direct or indirect contact with the urine of infected reservoir animals. Among wildlife species, rodents act as the most important reservoir for both human and animal infection. To gain a better understanding of the occurrence and distribution of pathogenic leptospires in rodent and shrew populations in Germany, kidney specimens of 2973 animals from 11 of the 16 federal states were examined by PCR. Rodent species captured included five murine species (family Muridae), six vole species (family Cricetidae) and six shrew species (family Soricidae). The most abundantly trapped animals were representatives of the rodent species Apodemus flavicollis, Clethrionomys glareolus and Microtus agrestis. Leptospiral DNA was amplified in 10% of all animals originating from eight of the 11 federal states. The highest carrier rate was found in Microtus spp. (13%), followed by Apodemus spp. (11%) and Clethrionomys spp. (6%). The most common Leptospira genomospecies determined by duplex PCR was L. kirschneri, followed by L. interrogans and L. borgpetersenii; all identified by single locus sequence typing (SLST). Representatives of the shrew species were also carriers of Leptospira spp. In 20% of Crocidura spp. and 6% of the Sorex spp. leptospiral DNA was detected. Here, only the pathogenic genomospecies L. kirschneri was identified.

show abstract

“…foraging), pest control is challenging . This problem has increased in certain regions on account of the emergence of rodenticide‐resistant rats …”

Section: Introductionmentioning

confidence: 99%

Survey for zoonotic pathogens in Norway rat populations from Europe

et al. 2016

View full text Add to dashboard Cite

Study results indicate a broad geographical distribution of Leptospira DNA in rats within Europe, underlining the need to investigate further the potential mechanisms leading to increased prevalence in rural habitats and to assess the relevance to public health. In contrast, rickettsia and OPV infections rarely occurred in wild rat populations. The potential influence of rat PyV on the susceptibility to infections with other pathogens should be investigated in future studies. © 2016 Society of Chemical Industry.

show abstract

Distribution of rodenticide resistance and zoonotic pathogens in Norway rats in Lower Saxony and Hamburg, Germany

Cited by 40 publications

References 18 publications

Distribution of anticoagulant rodenticide resistance inRattus norvegicusin the Netherlands according toVkorc1mutations

Distribution of anticoagulant rodenticide resistance inRattus norvegicusin the Netherlands according toVkorc1mutations

Leptospira spp. in Rodents and Shrews in Germany

Survey for zoonotic pathogens in Norway rat populations from Europe

Contact Info

Product

Resources

About