Distribution of Risk Factors and Prophylactic Drug Usage in Turkish Patients with Angiographically Established Coronary Artery Disease

Abstract

Background Coronary artery disease (CAD) is the leading cause of adult deaths in our country. In clinical practice, an adequate level of secondary prevention towards CAD primarily requires full recognition of the distribution of risk factors. The aim of our study was to determine the prevalence of coronary risk factors and the use of prophylactic drugs among patients who have an angiographically proven CAD in our centre, and to compare it with those of the EUROASPIRE I and II studies.Design Cross-sectional, observational study.Methods Our patients comprise 617 subjects (516 male, mean age 57.2 7 10.8 years) who underwent an angiography between January 2000 and May 2000 for the first time and in whom significant coronary lesions were detected. Age, gender, family history of premature CAD (FH), diabetes mellitus (DM), hypertension (HT), lipid profile, smoking, body mass index, waist circumference, hip circumference and physical activity data were recorded prior to angiography.The medical treatments received by these cases at discharge from hospital were investigated. Data thus obtained were compared with the results of the EURO-ASPIRE I and II trials, which studied the frequency of existing risk factors and prophylactic drug use among CAD patients in European countries.Results Hyperlipidaemia, FH, DM, HT, smoking, obesity, central obesity were found in 52, 26, 20, 41, 65, 18 and 29% of patients, respectively.The use of antiplatelets, beta-blockers, ACE inhibitors, statins and calcium antagonists were 99, 86, 40, 63 and 16%, respectively.Conclusion Upon comparison of the risk factors, prevalence of obesity and DM was found to be similar to the average of nine European countries among our subjects. Smoking was found to be considerably higher, whereas HT, hyperlipidaemia and family history of premature CAD were lower than the European average within our subjects. In our cases the frequency of prophylactic drug usage at discharge was higher than the European means.

Prevalence of Coronary Artery Disease in Patients Undergoing Valvular Heart Surgery

“…An interesting finding in the present study was that CAD risks varied along with the type of valve disease as previously reported [Emren 2014;Sonmez 2002]. Thalji and colleagues found that patients with aortic valve diseases were more likely to have CAD than those with mitral valve diseases [Thalji 2013], which also was observed in our investigation.…”

Effect of the G-308A polymorphism of the tumor necrosis factor (TNF)-α gene promoter site on plasma levels of TNF-α and C-reactive protein in smokers: a cross-sectional study

“…Several studies have revealed increased plasma levels of TNF-α and of CRP in smokers as compared to non-smokers [10,11], suggesting that part of the coronary risk associated with smoking may relate to increased inflammatory activity. However, the prevalence of cardiovascular disease varies substantially among smoking individuals [12]. This could indicate that genetic factors are important determinants of the biological pathways linking smoking with cardiovascular disease risk [13].…”

Explaining the decline in coronary heart disease mortality in Turkey between 1995 and 2008

“…The demographic information was obtained from the census data that covered whole country, the risk factor trends were obtained from national epidemiological studies. Treatment uptake data was obtained from multicentre national studies (EUROASPIRE III [ 26 ], PREMISE [ 27 ]) and from a hospital based surveys conducted in recent years [ 43 , 61 , 62 ]. Certain assumptions were therefore taken to fill in the gaps for missing information including specific patient groups’ data.…”