Distribution of reference GFR in a development population – a critical factor for the establishment of a GFR estimation equation

Estimating glomerular filtration rate by serum creatinine or/and cystatin C equations: An analysis of multi‐centre Chinese subjects

“…Thirdly, the distribution of rGFR in the developing population also contributed to the disparities. It was stated that if the development population had relatively low rGFR, the empirical equation tended to output lower GFR . This may help with the interpretation of parallel performance between the CKD‐EPI equations and Feng equations, besides the Ma equations’ poor performance in our study.…”

“…It was stated that if the development population had relatively low rGFR, the empirical equation tended to output lower GFR. 27 This may help with the interpretation of parallel performance between the CKD-EPI equations and Feng equations, besides the Ma equations' poor performance in our study. In addition, the discrepancies may be a result of differences arising from the population differences, such as the different constituent ratio of the individual's age, gender, and complications, etc.…”

“…Secondly, the serum creatinine and cystatin C assay and calibration were different between studies. Taking cystatin C for example, cystatin C measured by the particle‐enhanced turbidimetric immunoassay (PETIA) method was reported to be 27.5% higher than that by the PENIA method . The difference of serum creatinine assay and calibration used in this study and the CKD‐EPI study also leaded to the apparent discrepancies.…”

“…Taking cystatin C for example, cystatin C measured by the particle-enhanced turbidimetric immunoassay (PETIA) method was reported to be 27.5% higher than that by the PENIA method. 27,28 The difference of serum creatinine assay and calibration used in this study and the CKD-EPI study also leaded to the apparent discrepancies. Thirdly, the distribution of rGFR in the developing population also contributed to the disparities.…”

A New Equation to Estimate Glomerular Filtration Rate in Chinese Elderly Population

“…And the mean mGFR in our study was much lower than that in the CKD-EPI equation, too. Differences in the study population lead to errors in the comparison between two GFR estimating equations [19] . Second, the method to measure GFR was different.…”