Distribution of phthalates, pesticides and drug residues in the dissolved, particulate and sedimentary phases from transboundary rivers (France–Belgium)

Net, Sopheak; Rabodonirina, Suzanah; Sghaier, Rafika Ben; Dumoulin, David; Chbib, Chaza; Tlili, Imen; Ouddane, Baghdad

doi:10.1016/j.scitotenv.2015.03.087

Cited by 92 publications

(14 citation statements)

References 44 publications

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“…High purity nitrogen was employed as the purge gas. Extracts were then combined and subjected to a purification step described elsewhere (Net et al 2015) with the focus to remove the interferences. Each sediment sample was concentrated to 250 μL in hexane for sediment sample.…”

Section: Extraction Procedures For Edcsmentioning

confidence: 99%

Distribution and estrogenic potential of endocrine disrupting chemicals (EDCs) in estuarine sediments from Mumbai, India

Tiwari

Sahu

Pandit

2016

Environ Sci Pollut Res

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Endocrine disrupting chemicals (EDCs) are responsible for inappropriate development and they alter the hormonal and homeostatic systems of organism. Phthalates (PAEs), bisphenol A (BPA) and other EDCs were monitored in surface sediments at different stations across Thane Creek, India. Analysis of PAEs was carried out using GC-MS technique, while BPA and other EDCs were analyzing on UPLC-PDA instrument. Di-n-butyl phthalate (DBP) had the highest concentration among all fourteen analyzed phthalates ranges between 0.13 and 0.4 mg kg(-1); and was detectable in all sediment samples. Strong correlation (r = 0.95, p < 0.01) was observed between total organic carbon (TOC, %) and total PAEs. BPA was also detected in all samples; average BPA concentration varies from 16.3 to 35.79 μg kg(-1) with mean value 25.15 μg kg(-1) dry weight of sediment. Synthetic EDCs such as 4-para-nonylphenol (NP) and 4-tert-octylphenol (OP) were also analyzed; and their average concentrations were founds to be 356.5 and 176 μg kg(-1), respectively. Estrone (E1), 17β-estradiol (E2), and 17α-ethinylestradiol (EE2) were the main contributors to the overall estradiol equivalent concentration (EEQs) in sediment, their average total percentage contributions is more than 90 %.

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Section: Extraction Procedures For Edcsmentioning

confidence: 99%

Distribution and estrogenic potential of endocrine disrupting chemicals (EDCs) in estuarine sediments from Mumbai, India

Tiwari

Sahu

Pandit

2016

Environ Sci Pollut Res

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“…Epidemiological studies have indicated a significant exposure of humans to phthalates, which is associated with their softening properties, and therefore common use in food, pharmaceutical and cosmetic industry 9 , 10 . In Europe, approximately 1 million tons of phthalic acid esters (PAEs) are used annually, and the world annual consumption of those compounds is approximately 30 million tons 11 , 12 . According to the EU Commission Directive 2018/2005, four phthalates, including DEHP (di(2-ethylhexyl) phthalate), DBP, BBP and DIBP (diisobutyl phthalate), are considered to be harmful for human reproduction (category 1B).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic risk assessment and mechanism of DNA damage induced by phthalates and their metabolites in human peripheral blood mononuclear cells

Sicińska

Mokra

Woźniak

et al. 2021

Sci Rep

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The human genome is persistently exposed to damage caused by xenobiotics, therefore the assessment of genotoxicity of substances having a direct contact with humans is of importance. Phthalates are commonly used in industrial applications. Widespread exposure to phthalates has been evidenced by their presence in human body fluids. We have assessed the genotoxic potential of selected phthalates and mechanism of their action in human peripheral blood mononuclear cells (PBMCs). Studied cells were incubated with di-n-butyl phthalate (DBP), butylbenzyl phthalate (BBP) and their metabolites: mono-n-butylphthalate (MBP), mono-benzylphthalate (MBzP) in the concentrations range of 0.1–10 µg/mL for 24 h. Analyzed compounds induced DNA single and double strand-breaks (DBP and BBP ≥ 0.5 µg/mL, MBP and MBzP ≥ 1 µg/mL) and more strongly oxidized purines than pyrimidines. None of the compounds examined was capable of creating adducts with DNA. All studied phthalates caused an increase of total ROS level, while hydroxyl radical was generated mostly by DBP and BBP. PBMCs exposed to DBP and BBP could not completely repair DNA strand-breaks during 120 min of postincubation, in opposite to damage caused by their metabolites, MBP and MBzP. We have concluded that parent phthalates: DBP and BBP caused more pronounced DNA damage compared to their metabolites.

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“…In plasticizers, PAEs are characterized by low water solubility and high octanol/water partition coefficients, but are not covalently bound to plastics [6]. The global production of PAEs was approximately 1.8 million tons in 1975, 6.2 million tons in 2009 and increased to more than 8 million tons in 2015 [7][8][9][10]. Due to its higher production and application figures, PAEs are widely distributed in various environmental samples such as the air [11], freshwater [12,13], sediment [14,15] and soil [5,[16][17][18].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Di-n-Butyl Phthalate Phytoremediation by Garden Lettuce (Lactuca sativa L. var. longifolia) through Kinetics and Proteome Analysis

2019

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Di-n-dutyl phthalate (DBP), an endocrine disruptor, is one of the most widely used phthalate esters (PAEs) in the world. It can be accumulated in seafood or agricultural products and represents a substantial risk to human health via the food chain. Thus, finding a plant which can remediate DBP but have no effects on growth is the main topic of the development of DBP phytoremediation. This study used garden lettuce (Lactuca sativa L. var. longifolia), which has a significant DBP absorption capability, as a test plant to measure phytoremediation kinetics and proteome changes after being exposed to DBP. The results show that DBP accumulated in different parts of the garden lettuce but the physiological status and morphology showed no significant changes following DBP phytoremediation. The optimal condition for the DBP phytoremediation of garden lettuce is one critical micelle concentration (CMC) of non-ionic surfactant Tween 80 and the half-life (t1/2, days), which calculated by first-order kinetics, was 2.686 days for 5 mg L−1 of DBP. This result indicated that the addition of 1 CMC of Tween 80 could enhance the efficiency of DBP phytoremediation. In addition, the results of biotoxicity showed that the median effective concentration (EC50) of DBP for Chlorella vulgaris is 4.9 mg L−1. In this case, the overall toxicity markedly decreased following phytoremediation. In the end, the result of proteome analysis showed six protein spots, revealing significant alterations. According to the information of these proteomes, DBP potentially causes osmotic and oxidative stress in garden lettuce. In addition, since DBP had no significant effects on the morphology and physiological status of garden lettuce, garden lettuce can be recommended for use in the plant anti-DBP toxicity test, and also as the candidate plant for DBP phytoremediation. We hope these findings could provide valuable information for DBP-contaminated water treatment in ecological engineering applications or constructed wetlands.

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Distribution of phthalates, pesticides and drug residues in the dissolved, particulate and sedimentary phases from transboundary rivers (France–Belgium)

Cited by 92 publications

References 44 publications

Distribution and estrogenic potential of endocrine disrupting chemicals (EDCs) in estuarine sediments from Mumbai, India

Distribution and estrogenic potential of endocrine disrupting chemicals (EDCs) in estuarine sediments from Mumbai, India

Genotoxic risk assessment and mechanism of DNA damage induced by phthalates and their metabolites in human peripheral blood mononuclear cells

Characterization of Di-n-Butyl Phthalate Phytoremediation by Garden Lettuce (Lactuca sativa L. var. longifolia) through Kinetics and Proteome Analysis

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