Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic

Li, Xing; Li, Tuo; Wang, Zhenpeng; Wei, Jinchao; Liu, Jianan; Zhang, Yangyang; Zhao, Zhenwen

doi:10.1016/j.talanta.2021.122150

Cited by 35 publications

(30 citation statements)

References 46 publications

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“…PFOS mainly affected glycerophospholipid metabolism and sphingolipid metabolism in liver. These authors suggested that the upregulated ceramide and lysophosphatidylcholine (LPC) might lead to liver cell apoptosis, while decrease in liver triglyceride (TG) content might result in insufficient energy and cause liver morphological damage [231]. After the dietary exposure of rats to 20 or 100 ppm PFOS for 7 days, Elcombe et al (2012) have also noted alterations in various liver parameters (e.g., increased liver weight; decreased plasma cholesterol, alanine aminotransferase, and triglycerides; increased hepatocellular cytosolic CYP450 concentration; increased liver activity of acyl CoA oxidase, CYP4A, CYP2B, and CYP3A; increased liver proliferative index and decreased liver apoptotic index).…”

Section: In Vivo Studies On Pfas Effectsmentioning

confidence: 99%

PFAS Molecules: A Major Concern for the Human Health and the Environment

Panieri

Baralić

Đukić-Ćosić

et al. 2022

Toxics

179

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Per- and polyfluoroalkyl substances (PFAS) are a group of over 4700 heterogeneous compounds with amphipathic properties and exceptional stability to chemical and thermal degradation. The unique properties of PFAS compounds has been exploited for almost 60 years and has largely contributed to their wide applicability over a vast range of industrial, professional and non-professional uses. However, increasing evidence indicate that these compounds represent also a serious concern for both wildlife and human health as a result of their ubiquitous distribution, their extreme persistence and their bioaccumulative potential. In light of the adverse effects that have been already documented in biota and human populations or that might occur in absence of prompt interventions, the competent authorities in matter of health and environment protection, the industries as well as scientists are cooperating to identify the most appropriate regulatory measures, substitution plans and remediation technologies to mitigate PFAS impacts. In this review, starting from PFAS chemistry, uses and environmental fate, we summarize the current knowledge on PFAS occurrence in different environmental media and their effects on living organisms, with a particular emphasis on humans. Also, we describe present and provisional legislative measures in the European Union framework strategy to regulate PFAS manufacture, import and use as well as some of the most promising treatment technologies designed to remediate PFAS contamination in different environmental compartments.

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Section: In Vivo Studies On Pfas Effectsmentioning

confidence: 99%

PFAS Molecules: A Major Concern for the Human Health and the Environment

Panieri

Baralić

Đukić-Ćosić

et al. 2022

Toxics

179

View full text Add to dashboard Cite

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“…PFOS can cause hepatic steatosis in humans and reduce postnatal survival and growth in rodents [ 54 ]. Studies in mice have also shown that PFOS accumulates most in the liver, followed by the lungs, kidneys, spleen, heart, and brain, causing the most serious damage to the liver [ 55 ]. An analysis of wild freshwater fish collected from rivers in the Pearl River Delta region of China also demonstrated that PFOS was the major PFAS in fish liver [ 56 ].…”

Section: Relationship Between Pfos and The Livermentioning

confidence: 99%

“…Using liver lipidomic analysis in mice, it was found that phosphatidylcholine (PC) synthesis via the phosphatidylethanolamine N-methyltransferase (PEMT) pathway may be a self-protective mechanism against PFOS-induced inflammation in animals [ 55 ]. PC has a variety of beneficial effects, including anti-inflammatory, antioxidant, and anti-fibrotic activities.…”

Section: Signaling Pathways Associated With Hepatotoxic Damage Caused...mentioning

confidence: 99%

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Wang

Liu

Yan

et al. 2022

Toxics

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Perfluorooctane sulfonate (PFOS) is a persistent, widely present organic pollutant. PFOS can enter the human body through drinking water, ingestion of food, contact with utensils containing PFOS, and occupational exposure to PFOS, and can have adverse effects on human health. Increasing research shows that the liver is the major target of PFOS, and that PFOS can damage liver tissue and disrupt its function; however, the exact mechanisms remain unclear. In this study, we reviewed the adverse effects of PFOS on liver tissue and cells, as well as on liver function, to provide a reference for subsequent studies related to the toxicity of PFOS and liver injury caused by PFOS.

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“…Mounting data suggest PFAS are likely neurotoxic and may modulate neurological function (exemplified by an outstanding recent review by Cao and Ng in 2021, broadly addressing neurotoxicity). PFAS accumulate in the greatest amounts in the blood, liver, lung, and kidney . Reports of neurotoxicity are present at relatively low amounts accumulating in the brain. ,,, However, recent experiments quantifying PFAS in cerebrospinal fluid (CSF) and post-mortem human brains suggest these earlier studies may be underestimating the concentrations that PFAS accumulate in the brain .…”

Section: Pfas In the Brainmentioning

confidence: 99%

“…Table summarizes the studies that have quantified PFAS accumulation (PFOS, PFOA, PFHxS, and PFHxA) in different regions of the brain and blood or serum. Importantly, systemic PFAS levels are what is most often used as a biomarker of organismal PFAS exposure and have been reported to be magnitudes higher than the levels that accumulate in the brain. ,, A study of Chinese people found that PFAS in CSF were only 2–3-fold lower in the CSF compared to plasma levels of PFAS, which demonstrated the plasma levels may be an underestimation of how much PFAS get distributed to and accumulate in the brain.An earlier 2006 human study of PFAS in brain and blood sample levels (sampled from northern Italy) demonstrated a 5-fold lower difference between blood and brain PFOA or PFOS levels …”

Section: Pfas In the Brainmentioning

confidence: 99%

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes

Brown-Leung

Cannon

2022

Chem. Res. Toxicol.

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Per- and polyfluoroalkyl substances (PFAS) are a group of persistent environmental pollutants that are ubiquitously found in the environment and virtually in all living organisms, including humans. PFAS cross the blood–brain barrier and accumulate in the brain. Thus, PFAS are a likely risk for neurotoxicity. Studies that measured PFAS levels in the brains of humans, polar bears, and rats have demonstrated that some areas of the brain accumulate greater amounts of PFAS. Moreover, in humans, there is evidence that PFAS exposure is associated with attention-deficit/hyperactivity disorder (ADHD) in children and an increased cause of death from Parkinson’s disease and Alzheimer’s disease in elderly populations. Given possible links to neurological disease, critical analyses of possible mechanisms of neurotoxic action are necessary to advance the field. This paper critically reviews studies that investigated potential mechanistic causes for neurotoxicity including (1) a change in neurotransmitter levels, (2) dysfunction of synaptic calcium homeostasis, and (3) alteration of synaptic and neuronal protein expression and function. We found growing evidence that PFAS exposure causes neurotoxicity through the disruption of neurotransmission, particularly the dopamine and glutamate systems, which are implicated in age-related psychiatric illnesses and neurodegenerative diseases. Evaluated research has shown there are highly reproduced increased glutamate levels in the hippocampus and catecholamine levels in the hypothalamus and decreased dopamine in the whole brain after PFAS exposure. There are significant gaps in the literature relative to the assessment of the nigrostriatal system (striatum and ventral midbrain) among other regions associated with PFAS-associated neurologic dysfunction observed in humans. In conclusion, evidence suggests that PFAS may be neurotoxic and associated with chronic and age-related psychiatric illnesses and neurodegenerative diseases. Thus, it is imperative that future mechanistic studies assess the impact of PFAS and PFAS mixtures on the mechanism of neurotransmission and the consequential functional effects.

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Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic

Cited by 35 publications

References 46 publications

PFAS Molecules: A Major Concern for the Human Health and the Environment

PFAS Molecules: A Major Concern for the Human Health and the Environment

Adverse Effects of Perfluorooctane Sulfonate on the Liver and Relevant Mechanisms

Neurotransmission Targets of Per- and Polyfluoroalkyl Substance Neurotoxicity: Mechanisms and Potential Implications for Adverse Neurological Outcomes

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