Distribution of peptide YY in the gastrointestinal tract of the rat, dog, and monkey

Greeley, George H.; Hill, Freddie L.; Spannagel, Alan W.; Thompson, James C.

doi:10.1016/0167-0115(87)90178-9

Cited by 66 publications

(22 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PYY and PP are released from endocrine cells of the intestine and pancreas, respectively (Kimmel et al, 1984;Greeley et al, 1987), and can influence smooth muscle activity either directly via Y 2 and Y 4 receptors as shown in this study, or by interacting with receptors located on excitatory or inhibitory enteric neurons as shown in studies of innervated smooth muscle (Holzer et al, 1987;Krantis et al, 1988;Grider and Langdon;. NPY is present exclusively in neurons and is usually colocalized with vasoactive intestinal peptide and nitric oxide synthase in the stomach and intestine (Nichols et al, 1994;Schicho et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

Misra

Murthy²,

Zhou³

et al. 2004

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Coexpression of Y 1 , Y 2 , and Y 4 receptors on smooth muscle cells was determined by reverse transcription-polymerase chain reaction, and the receptors were characterized by radioligand binding, selective receptor protection, and functional analysis of signaling pathways. (Eva et al., 1990;Lundell et al., 1995;Rose et al., 1995;Berglund et al., 2003;Rodriguez et al., 2003). The abbreviated Y designation reflects the large number of tyrosine residues (Y in the single-letter amino acid code) present in their endogenous ligands, neuropeptide Y (NPY), and the hormonal peptides, peptide YY (PYY) and pancreatic polypeptide (PP) (Blomqvist and Herzog, 1997;Berglund et al., 2003). A putative Y 3 receptor has not been cloned and remains a pharmacological entity based on the existence in some models of widely divergent responses to NPY and PYY . Y 4 binds preferentially PP, whereas Y 1 , Y 2 , and Y 5 bind preferentially NPY and PYY (Berglund et al., 2003). The pharmacological profile of Y 6 has not been accurately determined. The pharmacological profile of Y 2 receptors is distinctive with high affinities for NPY, PYY, long C-terminal fragments of NPY or PYY (e.g., NPY , and the selective, nonpeptide antagonist BIIE 0246 (Rose et al., 1995;Dumont et al., 2000 ; IP 3 , inositol 1,4,5-trsiphosphate; CCK-8, cholecystokinin octapeptide; D600, methoxyverapamil; MLCK, myosin light chain kinase; ML-9, 1-(5- (Krause et al., 1992;Doods et al., 1995;Wieland et al., 1995;Weinberg et al., 1996;Rodriguez et al., 2003 (Lundell et al., 1995).Y receptors are widely distributed in the central and peripheral nervous systems (Sundler et al., 1993;Lomax and Furness, 2000). Although typical responses have been ascribed to specific receptors, variability is common. Thus, inhibition of neurotransmitter release, a prototypical response mediated by Y 2 receptors in some tissues, (e.g., vas deferens) is mediated by Y 1 receptors in the enteric nervous system (Wahlestedt et al., 1986;Grider and Langdon, 2003). Expression of Y receptors in non-neural tissues has usually been surmised from pharmacological profiles and only rarely by precise receptor mapping. In gastrointestinal tissues, for example, the response to NPY, PYY, or PP is often a compound of nerve-mediated and direct effects that involve more than one receptor type, leading to divergent results and interpretations (Feletou et al., 1998;Pheng et al., 1999;Ferrier et al., 2000Ferrier et al., , 2002. Recent studies have attempted to facilitate the interpretation of pharmacological studies by measurement of Y receptor expression (Goumain et al., 1998). Analysis of receptor expression by RT-PCR in heterogeneous tissues can be useful in identifying which receptor types are not expressed, but it has obvious limitations in assigning expressed receptors to specific tissues or cell types. This is illustrated by several recent studies of Y receptor expression in rat colon, where there was complete agreement on expression of Y 4 receptors, and clear differences on expression of Y 1 , Y ...

show abstract

Section: Discussionmentioning

confidence: 99%

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

Misra

Murthy²,

Zhou³

et al. 2004

J Pharmacol Exp Ther

View full text Add to dashboard Cite

show abstract

“…NPY is widely distributed in the central and peripheral nervous system and represents one of the most abundant neuropeptides (Mannon and Tailor 1994). PYY is present in endocrine cells in the lower intestine, stomach, and pancreas (Lundberg et al 1982;Greeley et al 1987;Onolfo et al 1989). …”

mentioning

confidence: 99%

Immunocytochemical Localization of the NPY/PYY Y1 Receptor in Enteric Neurons, Endothelial Cells, and Endocrine-like Cells of the Rat Intestinal Tract

Jackerott

Larsson

1997

J Histochem Cytochem.

View full text Add to dashboard Cite

SUMMARY Neuropeptide Y (NPY) and peptide YY (PYY) are structurally related peptides that are considered to mediate inhibitory actions on gastrointestinal motility, secretion, and blood flow. Several receptor subtypes for these peptides have been identified and the Y1, Y2, Y4/PP1, Y5, and Y5/PP2/Y2b receptors have been cloned. In this article we report the immunocytochemical localization of the Y1 receptor to myenteric and submucosal nerve cell bodies, endothelial cells, and scattered endocrine-like cells of rat intestinal tract. Moreover, double immunofluorescence demonstrates that subpopulations of the Y1 receptorpositive nerve cell bodies are immunopositive for NPY, vasoactive intestinal polypeptide, and nitric oxide synthase. In part, such co-localizations were made possible by use of peroxidase-mediated deposition of tyramide, which permitted use of antisera derived from the same species. Our observations suggest the existence of multiple neuronal, endothelial, and endocrine target sites for NPY and PYY and that some of the actions of these regulatory peptides can be mediated by vasoactive intestinal peptide and nitric oxide synthase.

show abstract

“…Peptide YY (PYY) is a gastrointestinal peptide found in the endocrine-like cells of the pancreatic islets (1,2) and the ileocolonic mucosa (3). Although PYY potently inhibits pancreatic and gastric secretion in vivo ( 4 3 , its mechanism of action remains unclear.…”

Section: Discussionmentioning

confidence: 99%

Adrenergic Pathways Do Not Mediate Peptide YY-Induced Inhibition of Pancreatic Exocrine Secretion

Brodish¹,

Kuvshinoff²,

McFadden³

et al. 1995

Pancreas

View full text Add to dashboard Cite

The influence of extrapancreatic nerves and intrapancreatic adrenergic activity on the inhibition of pancreatic exocrine secretion by peptide YY (PYY) was studied in conscious dogs. Chronic pancreatic fistulae were created in five mongrel dogs while a second group of five dogs also underwent complete pancreatic denervation. After recovery, a continuous infusion of secretin (62 ng/kg/h) and cholecystokinin (CCK; 50 ng/kg/h) was administered over 2 h. An infusion of PYY (400 pmol/kg/h) was then given randomly, during either the first or second experimental hour. The experiments were then replicated after establishing adrenergic blockade with continuous background infusions of either phentolamine (0.2 mg/kg/ h), propranolol (0.5 mg/kg bolus) or a combination of phentolamine and propranolol. The secretinicholecystokinin-induced bicarbonate and protein outputs were significantly inhibited by PYY in both the innervated and denervated animals. Adrenergic blockade failed to eliminate the inhibitory effects of PYY. We conclude that extrapancreatic neural pathways, including adrenergic mechanisms, do not mediate the inhibitory effects of PYY. The results suggest that PYY inhibits secretidcholecystokinin-induced pancreatic response by an indirect nonadrenergic mechanism.

show abstract

Distribution of peptide YY in the gastrointestinal tract of the rat, dog, and monkey

Cited by 66 publications

References 15 publications

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

Immunocytochemical Localization of the NPY/PYY Y1 Receptor in Enteric Neurons, Endothelial Cells, and Endocrine-like Cells of the Rat Intestinal Tract

Adrenergic Pathways Do Not Mediate Peptide YY-Induced Inhibition of Pancreatic Exocrine Secretion

Contact Info

Product

Resources

About

Distribution of peptide YY in the gastrointestinal tract of the rat, dog, and monkey

Cited by 66 publications

References 15 publications

Coexpression of Y1, Y2, and Y4 Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

Coexpression of Y1, Y2, and Y4 Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

Immunocytochemical Localization of the NPY/PYY Y1 Receptor in Enteric Neurons, Endothelial Cells, and Endocrine-like Cells of the Rat Intestinal Tract

Adrenergic Pathways Do Not Mediate Peptide YY-Induced Inhibition of Pancreatic Exocrine Secretion

Contact Info

Product

Resources

About

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways

Coexpression of Y₁, Y₂, and Y₄ Receptors in Smooth Muscle Coupled to Distinct Signaling Pathways