Distribution of PCDDs/PCDFs and Co-PCBs in Human Maternal Blood, Cord Blood, Placenta, Milk, and Adipose Tissue: Dioxins Showing High Toxic Equivalency Factor Accumulate in the Placenta

Suzuki, Go; Nakano, Masahiro; Nakano, Shiro

doi:10.1271/bbb.69.1836

Cited by 83 publications

(59 citation statements)

References 34 publications

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“…In particular, 2,3,7,8-TeCDD, 1,2,3,7,8-PeCDD, and 2,3,4,7,8-PeCDF are found in significantly greater amounts in the placenta. Thus, there is a specific accumulation of these three PCDDs/PCDFs congeners in the placenta due to their high affinity for the Ah receptor (Wang et al, 2004;Suzuki et al, 2005). These three TEF values (0.3 to 1) are higher than those of other congeners (0.00003 to 0.1) (Van den Berg et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

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Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

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Several human studies have shown that low-level exposure to environmental contaminants, such as polychlorinated biphenyls (PCBs) and organochlorine pesticides, negatively influences birth outcomes.However, the effects of low-level exposure to polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and dioxin-like PCBs (DL-PCBs) on birth outcomes have not been clarified in human studies.A prospective cohort study was established to investigate the possible adverse effects of PCDDs/PCDFs and DL-PCBs on fetal growth and neurodevelopment. We recruited 514 pregnant women between July 2002 and October 2005 in Sapporo, Japan. We measured 29 congener levels of PCDDs/PCDFs and DL-PCBs in maternal blood.Using multiple liner regression analysis of the association between birth weight and the levels of PCDDs/PCDFs and DL-PCBs with full adjustments for potential confounders, a significant adverse effect was observed regarding total PCDDs toxic equivalents (TEQ) levels (adjusted β = -231.5 g, 95% CI: -417.4 to -45.6) and total PCDFs TEQ levels (adjusted β = -258.8 g, 95% CI: -445.7 to -71.8). Among male infants, significant adverse associations with birth weight were found for total PCDDs TEQ level, total PCDDs/PCDFs TEQ level, and total TEQ level. However, among female infants, these significant adverse associations were not found. With regard to individual congeners of PCDDs/PCDFs and DL-PCBs, we found significantly negative association with the levels of 2,3,4,7,8-PeCDF (adjusted β = -24.5 g, 95% CI: -387.4 to -61.5).Our findings suggest that prenatal low-level exposure to PCDDs and PCDFs, especially 2,3,4,7,8-PeCDF, may accumulate in the placenta and retard important placental functions, which result in lower birth weight.

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Section: Discussionmentioning

confidence: 99%

“…One of the most significant concerns regarding health effects is the harmful influence of PCBs and PCDDs/PCDFs on future generations, stemming from prenatal and/or postnatal exposure. Pregnant and nursing women pass these pollutants to their babies both trans-placentally and lactationally (Suzuki et al, 2005;Wang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Konishi

Sasaki

Kato

et al. 2009

Environmental Research

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“…Pregnant and nursing women pass these pollutants to their babies both transplacentally and via lactation, and evaluating the maternal contamination is an indirect measurement of the exposure of the foetus to external contaminants (Suzuki et al, 2005;Wang et al, 2004). One of the most significant concerns regarding health effects is the harmful influence of PCBs and PCDDs/PCDFs on future generations, stemming from prenatal and/or postnatal exposure (Konishi et al, 2009;Wang et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of São Paulo State, Brazil

Rudge

Sandanger

Röllin

et al. 2012

Environment International

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2012Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of Sao Paulo State, Brazil ENVIRONMENT INTERNATIONAL, OXFORD, v. 40, Persistent organic pollutants (POPs) present in the living environment are thought to have detrimental health effects on the population, with pregnant women and the developing foetus being at highest risk. We report on the levels of selected POPs in maternal blood of 155 delivering women residing in seven regions within the São Paulo State, Brazil. The following selected POPs were measured in the maternal whole blood: 12 polychlorinated biphenyls (PCBs) congeners (IUPAC Nos. 99, 101, 118, 138, 153, 156, 163, 170, 180, 183, 187, 194); dichlordiphenyltrichloroethane p,p′-DDT, diphenyldichloroethylene p,p′-DDE and other pesticides such as hexachlorocyclohexanes (α-HCH, β-HCH, γ-HCH), hexachlorobenzene (HCB), chlordane derivatives cis-chlordane, transchlordane, oxy-chlordane, cis-nonachlor and trans-nonachlor. Statistical comparisons between regions were performed only on compounds having concentrations above LOD in 70% of the samples. PCB118 congener was found to be highest in the industrial site (mean 4.97 ng/g lipids); PCB138 congener concentration was highest in the Urban 3 site (mean 4.27 ng/g lipids) and congener PCB153 was highest in the industrial and Urban 3 sites with mean concentration of 7.2 ng/g lipids and 5.89 ng/g lipids respectively. Large differences in levels of p,p′-DDE between regions were observed with the Urban 3 and industrial sites having the highest concentrations of 645 ng/g lipids and 417 ng/g lipids, respectively; β-HCH was found to be highest in the Rural 1 site; the γ-HCH in Rural 1 and industrial; the HCB in the Rural 1 and industrial sites and oxy-chlordane and t-NC in the Rural 2 sites. An association between levels of some contaminants and maternal age and parity was also found.

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“…Mothers who are exposed to dioxins could potentially expose their offspring to dioxin during pregnancy as a result of circulation of maternal blood through the placenta (Suzuki et al 2005). A previous report estimated that an infant who is breastfed for 1 year accumulates a dose of dioxin that is 6-fold higher than that in an infant who is not breastfed (Lorber & Phillips 2002).…”

Section: Discussionmentioning

confidence: 99%

“…These chemical toxics, which include polychlorinated dibenzo-pdioxins, dibenzofurans, and PCBs, affect children's growth as a result of prenatal or postnatal exposure (Wang et al 2004). Pregnant and nursing women may pass the dioxins and/or PCBs to their newborns via transplacental transfer and by breastfeeding mothers (Suzuki et al 2005, Wang et al 2004. Several studies on exposure to lower levels of dioxins or PCBs during pregnancy have shown a relationship with low birth weight and other growth parameters (HertzPicciotto et al 2005, Patandin et al 1998, Sonneborn et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

Tung

Kido

Honma

et al. 2016

Environ Sci Pollut Res

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We aimed to determine the relationship between dioxin congeners in maternal breast milk and maternal glucocorticoid levels with newborn birth weight after nearly 45 years of use of herbicides in the Vietnam War. The study subjects comprised 58 mother-infant pairs in a region with high dioxin levels in the soil (hotspot) and 62 pairs from a control region. Dioxin levels in maternal breast milk were measured by HRGC-HRMS. Salivary glucocorticoid levels were determined by LC-MS/MS. Dioxin congener levels in mothers from the hotspot were found to be 2-5-fold higher than those in mothers from the control region. Birth weight was inversely correlated with 2,3,7,8-TeCDD and 2,3,4,7,8-PeCDF congener levels. The rate of newborns whose birth weight was less than 2500 g was 3-fold higher in the hotspot (12%) than in the control region (4%). Salivary glucocorticoid levels in mothers with low birth weight infants were significantly higher than those in the normal birth weight group. Low birth weight of Vietnamese newborns in a hotspot for dioxin levels is related to some dioxin congener levels and high glucocorticoid levels in mothers. This finding in mother-infant pairs suggests that excess maternal glucocorticoid levels are related to dioxin burden and they result in low birth weight.

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Distribution of PCDDs/PCDFs and Co-PCBs in Human Maternal Blood, Cord Blood, Placenta, Milk, and Adipose Tissue: Dioxins Showing High Toxic Equivalency Factor Accumulate in the Placenta

Cited by 83 publications

References 34 publications

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Prenatal exposure to PCDDs/PCDFs and dioxin-like PCBs in relation to birth weight

Levels of selected persistent organic pollutants in blood from delivering women in seven selected areas of São Paulo State, Brazil

Low birth weight of Vietnamese infants is related to their mother’s dioxin and glucocorticoid levels

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