Distribution of pathogens causing nosocomial infection in patients with bronchial asthma

Mao, Wenzhe; Cui, E H

doi:10.4238/2015.december.8.3

Cited by 5 publications

(4 citation statements)

References 27 publications

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“…Atopy and asthma were common in two case series of patients with subnormal IgG1 [7, 8] and in 121 adult patients with subnormal IgG3 [19]. Allergic asthma increases risk of lower respiratory tract infections in subjects not selected for subnormal immunoglobulin level [43, 44]. In another study, viral or bacterial infections were detected in 70% of inpatients with exacerbation of asthma [45].…”

Section: Discussionmentioning

confidence: 99%

Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

Parker¹,

Sköld²,

Harding³

et al. 2019

BMC Immunol

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Background: We sought to compare Pneumovax®23 responses in adults with subnormal IgG subclass concentrations. We studied adults with normal total IgG, frequent/severe respiratory infection, and subnormal IgG1, IgG3, or IgG1 + IgG3 before and after Pneumovax®23. We defined response as serotype-specific IgG > 1.3 μg/mL and aggregate response as IgG > 1.3 μg/mL for ≥70% of all serotypes tested. We compared patients with and without serotype-specific responses and performed logistic regression on aggregate responses using: age; male sex; body mass index; autoimmune condition(s); atopy; other allergies; subnormal IgGSc immunophenotypes; IgA; and IgM. Results: There were 59 patients (mean age 44 ± 13 (SD) years; 83.1% women). Median days between pre-and post-Pneumovax®23 testing was 33 (range 19-158). The median post-vaccination summated concentration of serotypespecific IgG was higher in patients with subnormal IgG1 than subnormal IgG3 (responders and non-responders). All subnormal IgG1 + IgG3 non-responders responded to serotypes 8, 9 and 26, unlike other non-responders. Subnormal IgG3 responders had lower responses to serotypes 1, 4, 12, 23, 26, and 51. Subnormal IgG3 nonresponders had higher responses to serotypes 1, 3, 8, 9, 12, 14, 19, 51, and 56. Response rates decreased with increasing age. Aggregate responders were: subnormal IgG1, 54%; IgG3, 46%; and IgG1 + IgG3, 46%. Regression on aggregate response revealed lower response with male sex (odds ratio 0.09 [95% CI 0.01, 0.77]) and atopy (0.17 [0.03, 0.83]). Conclusions: Serotype-specific IgG responses to Pneumovax®23 were greater in patients with subnormal IgG1 than subnormal IgG3. Male sex and atopy were associated with lower aggregate responses.

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Section: Discussionmentioning

confidence: 99%

Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

Parker¹,

Sköld²,

Harding³

et al. 2019

BMC Immunol

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show abstract

“…Atopy and asthma were prominent manifestations in 57 other adults with selective subnormal IgG1 [ 6 ]. Allergic asthma increases risk of lower respiratory tract infections in subjects not selected for subnormal immunoglobulin levels [ 43 – 45 ]. In one study, viral or bacterial infections were detected in 70% of inpatients with exacerbation of asthma [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections

Bertoli

Barton

Acton

2016

Journal of Immunology Research

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We characterized 54 adult index patients with reports of frequent or severe bacterial respiratory tract infections at diagnosis of selective subnormal IgG1. Mean age was 50 ± 13 (SD) y; 87.0% were women. Associated disorders included the following: autoimmune conditions 50.0%; hypothyroidism 24.1%; atopy 38.9%; and other allergy 31.5%. In 35.5%, proportions of protective S. pneumoniae serotype-specific IgG levels did not increase after polyvalent pneumococcal polysaccharide vaccination (PPPV). Blood lymphocyte subset levels were within reference limits in most patients. Regressions on IgG1 and IgG3 revealed no significant association with age, sex, autoimmune conditions, hypothyroidism, atopy, other allergy, corticosteroid therapy, or lymphocyte subsets. Regression on IgG2 revealed significant associations with PPPV response (negative) and CD19+ lymphocytes (positive). Regression on IgG4 revealed significant positive associations with episodic corticosteroid use and IgA. Regression on IgA revealed positive associations with IgG2 and IgG4. Regression on IgM revealed negative associations with CD56+/CD16+ lymphocytes. Regressions on categories of infection revealed a negative association of urinary tract infections and IgG1. HLA-A⁎03, HLA-B⁎55 and HLA-A⁎24, HLA-B⁎35 haplotype frequencies were greater in 38 patients than 751 controls. We conclude that nonprotective S. pneumoniae IgG levels and atopy contribute to increased susceptibility to respiratory tract infections in patients with selective subnormal IgG1.

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“…Atopy and asthma were prominent manifestations in 57 other adults with selective subnormal IgG1 [6]. Allergic asthma increases risk of lower respiratory tract infections in subjects not selected for subnormal immunoglobulin levels [43][44][45]. In one study, viral or bacterial infections were detected in 70% of inpatients with exacerbation of asthma [46].…”

Section: Discussionmentioning

confidence: 99%

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

Barton

Bertoli²,

Acton

2016

Cellular Immunology

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Distribution of pathogens causing nosocomial infection in patients with bronchial asthma

Cited by 5 publications

References 27 publications

Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

Pneumococcal vaccination responses in adults with subnormal IgG subclass concentrations

Selective Subnormal IgG1 in 54 Adult Index Patients with Frequent or Severe Bacterial Respiratory Tract Infections

Selective subnormal IgG3 in 121 adult index patients with frequent or severe bacterial respiratory tract infections

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