Distribution of novel polymorphisms of the interleukin-8 and CXC receptor 1 and 2 genes in systemic sclerosis and cryptogenic fibrosing alveolitis

Abstract

This report describes an association between SSc and 2 polymorphisms occurring close to each other in the CXCR-2 gene. This finding and its functional significance need to be confirmed and analyzed in future studies.

Genetic variation in key molecules of the Th-17 immune response is not associated with risk for prosthetic joint infection in a Czech population

“…To strengthen our data, we recruited second control group (Czech population controls) and there was no difference in the distribution of 10 polymorphisms between the patients with PJI and the population controls without TJA. Moreover, the frequencies of the investigated polymorphisms within the IL17A, IL17F, IL4, IL12A, IL12B, IL23R, CXCL1, CXCL5 and CXCR2 genes corresponded to their distribution in other Caucasian populations [15][16][17][18][19][20][21] . Legend: Continuous data presented as median with interquartile (1st to 3rd) range in parentheses.…”

Evidence of potential interaction of chemokine genes in susceptibility to systemic sclerosis

“…For example, Karrer et al (10) found that the frequency of the GG homozygote in the CCL2 gene promoter was significantly higher in patients with SSc than in controls. Polymorphisms in the gene CXCR2 were associated with SSc in a Caucasian population (12). SNPs in the gene IL-1␣ were reported to be strongly related to the development of SSc (34,35).…”

“…Genomic DNA was extracted from the peripheral blood of all subjects, using the QIAamp Blood kit (Qiagen, Valencia, CA). Genotyping was carried out in accordance with published methods (12)(13)(14)(15)(16)(17). A polymerase chain reaction (PCR)-sequence-specific primer method was used to genotype CXCR1 ϩ827 G/C and CXCR2 ϩ786 C/T, while a PCR-restriction fragment length polymorphism method was used to genotype CXCL8 (interleukin-…”

Inflammation and Pulmonary Fibrosis

“…In three Caucasian populations there was an association between the TNF--308A allele and risk of IPF (Riha et al, 2004;Whyte et al, 2000), although this was not confirmed in a fourth population (Pantelidis et al, 2001). No associations were demonstrated for other TNF-polymorphisms, or polymorphisms in the genes encoding TNF-receptor II or lymphotoxin- (Renzoni et al, 2000). IL6 intron 4 A>G polymorphism was associated with severity of IPF, and co-carriage of TNFRII 1690C was associated with disease risk (Pantelidis et al, 2001).…”