Distribution of neurotensin-immunoreactive neurons in the digestive tract of the chicken

Atoji, Yasuro; Hirasawa, Yasunobu; Yamamoto, Yoshio; Suzuki, Yoshitaka

doi:10.1016/0165-1838(94)00172-g

Cited by 8 publications

(1 citation statement)

References 34 publications

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“…This property added to its cerebral expression indicated that the peptide could fulfill a dual function, as a neurotransmitter/neuromodulator in the central nervous system, and as a hormone in the periphery. NT is expressed in the central nervous system where it is located in neuronal synaptic vesicles (Uhl and Snyder, 1976; Bayer et al, 1991) and in the gastrointestinal tract (Goedert and Emson, 1983) in neuroendocrine cells (Atoji et al, 1995). NT is synthesized from a precursor following excision by prohormone convertases (Kitabgi, 2006).…”

Section: Introductionmentioning

confidence: 99%

Neurotensin and its receptors in the control of glucose homeostasis

Mazella¹,

Béraud-Dufour²,

Devader³

et al. 2012

Front. Endocrin.

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The pharmacological roles of the neuropeptide neurotensin through its three known receptors are various and complex. Neurotensin is involved in several important biological functions including analgesia and hypothermia in the central nervous system and also food intake and glucose homeostasis in the periphery. This review focuses on recent works dealing with molecular mechanisms regulating blood glucose level and insulin secretion upon neurotensin action. Investigations on crucial cellular components involved in the protective effect of the peptide on beta cells are also detailed. The role of xenin, a neurotensin-related peptide, on the regulation of insulin release by glucose-dependent insulinotropic polypeptide is summarized. The last section comments on the future research areas which should be developed to address the function of new effectors of the neurotensinergic system in the endocrine pancreas.

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Section: Introductionmentioning

confidence: 99%

Neurotensin and its receptors in the control of glucose homeostasis

Mazella¹,

Béraud-Dufour²,

Devader³

et al. 2012

Front. Endocrin.

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Distribution of neurotensin-containing neurons in the central nervous system of the pigeon and the chicken

et al. 1996

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Neurotensin is widely located in neurons of the central and peripheral nervous systems among mammalian species. To obtain a comparative evaluation, we examined the distribution of neurotensin-containing cell bodies and fibers in the central nervous system of the pigeon and the chicken. The pattern of localization of neurotensin immunoreactivity was similar in the two species. Abundant accumulations of neurotensin-containing cell bodies were found in the dorsolateral corticoid area, the piriform cortex, the parahippocampal area, the medial part of the frontal neostriatum, the lateral part of the caudal neostriatum, nucleus accumbens, the bed nucleus of the stria terminalis, ventral paleostriatum, the preoptic area, the ventromedial hypothalamic nucleus, the inferior hypothalamic nucleus, the infundibular hypothalamic nucleus, and the mammillary nuclei. Extremely dense networks of neurotensin-containing fibers were found in the pallial commissure, the lateral septal nucleus, the preoptic area, the periventricular gray around the third ventricle, the dorsalis hypothalamic area, the hypothalamic nuclei, the parabrachial nucleus, the locus ceruleus, and the dorsal vagal complex. Major differences of immunoreactivity between the two species were as follows. 1) The chicken neurohypophysis contained an extremely large accumulation of immunoreactive fibers, but there were few in the median eminence. The reverse was found in the pigeon. 2) The optic tectum in the pigeon contained immunoreactive cells and fibers in layers 2 and 4, but no immunoreactivity was seen in the chicken optic tectum. 3) The cerebellar cortex in the pigeon contained a small number of immunoreactive fibers, whereas that in the chicken did not. 4) The pigeon spinal cord contained immunoreactive neurons in the subependymal layer, but the chicken spinal cord did not. Our observations suggest the presence of a very wide network of neurotensin-containing neurons in the avian brain and spinal cord, which is also the case in mammals.

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Neural Secretions and Regulation of Gut Functions

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Gastrointestinal Physiology

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Distribution of neurotensin-immunoreactive neurons in the digestive tract of the chicken

Cited by 8 publications

References 34 publications

Neurotensin and its receptors in the control of glucose homeostasis

Neurotensin and its receptors in the control of glucose homeostasis

Distribution of neurotensin-containing neurons in the central nervous system of the pigeon and the chicken

Neural Secretions and Regulation of Gut Functions

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