Distribution of MR-CoNS in the clinical staffs of tertiary care hospital

Abstract

Methicillin-resistant coagulase-negative staphylococci (MR-CoNS) associated infection is a growing concern in healthcare settings now a day. MR-CoNS are the main infectious agents of the hospital acquired infection. Clinical staffs to patients transmission of resistant strains have caused a rapid increase in the prevalence of antimicrobial resistance in recent years. Growing rate of antimicrobial resistant against available antibiotics of MR-CoNS is a developing problem in low income or lower middle income counties. This study was conducted to determine the occurrence MR-CoNS isolated from different clinical staffs of tertiary care hospital. This prospective study conducted in clinical staffs, nasal swab were collected from all the participants. Screening of CoNS were done on the basis of cultural, morphological and biochemical tests, identification and AST analysis done by VITEK-2 automated system. Methicillin resistance pattern was checked by VITEK-2 and Kirby-Bauer disc diffusion method according to CLSI guideline. A total of 129 nasal swab samples were collected from clinical staffs, of which n=81 isolates (85.6%) were CoNS. Among n=81 CoNS, (48.12%) , (41.97%) , (7.4%) and (2.4%) were reported. Out of n=81 CoNS isolates, n=26 were conformed as MR-CoNS. Maximum methicillin resistance were reported in 53.48% (14/26), 42.30% (11/26), 3.84% (1/26) and 0% (0/26). Theoccurrence rate of MR-CoNS are higher (20.6%) in the healthcare workers and most of the methicillin resistant-CoNS isolates shows high level of resistance against widely used antibiotics but all the isolates susceptible against vancomycin.

Quantitative Analysis of Distribution and Reliability Based on Maximum Capacity Segmented Subscribers on Distribution Lines

“…For example, in the early 1990s, China had its own intellectual property rights of distribution network reliability assessment software (e.g., DSRE-TH1 and its upgraded version DSRE-TH2 developed by Tsinghua University) for urban network and agricultural network renovation [22,23]. Over the past decades, China's power system reliability management has been carried out in an organized and planned manner, which has not only well adapted to every change and reform in the development of China's electric power industry, but also strengthened and improved its own management system and capability during the reform, and guided the electric power enterprises to scientifically apply the various assessment indicators in the power reliability management in the safety production management It also guides the electric power enterprises to scientifically use various evaluation indicators in electric power reliability management for the analysis and evaluation of electric power system reliability [24]. Through the continuous research of researchers and the technical and management measures of power management departments, the level of power supply reliability in China has made great progress in the past 20 years, but the gap with developed countries is still obvious.…”