Distribution of MICA alleles and haplotypes associated with HLA in the Korean population

Allelic diversity of MICA gene and MICA/HLA-B haplotypic variation in a population of the Murcia region in southeastern Spain

“…For example, HLA-B*35, *53, and *58 alleles share a high degree of sequence homology and are considered to have been generated from the same progenitor allele [22]. The fact that they are all linked with the same MICA*002 allele, consistently detected both in the present work and in previously reported populations around the world [22,28,35,40], further supports the notion of a common ancestry.…”

MICA Polymorphism in a Population From North Morocco, Metalsa Berbers, Using Sequence-Based Typing

“…These associations have been previously reported [21]. The MICA*004-B*440301 is a known association found in whites and Asians [24,26,29]. MICA*004-B440301 haplotypes were Ͼ10% of total in ME.…”

“…MICA*00701-B*270502 is a known association found in Japanese [23], Koreans [24], and African Americans [25]; MICA*011-B*1402 was found in African Americans [25] and whites [26].…”

High frequencies of alleles MICA*020 and MICA*027 in Amerindians and evidence of positive selection on exon 3

“…Although MICA*00801 is the most frequent allele in almost all populations studied so far except Amerindians (Table 1), MICA*027 is common in Eastern Asians 28,29 and in all Amerindians analyzed, 27 except in the Kaingang population ( Table 1). The widespread distribution of allele MICA*00801 and its occurrence at high frequency and in many HLA haplotypes have led to the suggestion that it might be the ancestral MICA allele.…”

“…28 In the Korean population, it was associated mainly with HLA-B61 (40). 29 MICA*00801 has been observed in haplotypes with many HLA-B alleles, including -B40. 4 MICA*027 may have originated from MICA*00801 by a deletion of G in the STR region or, alternatively, by recombination or gene conversion with an allele with five STR repetitions and no insertion.…”