Distribution of Methyl Red on the Water–organic Liquid Interface in a Microchannel

Chemical processing on microchips for analysis, synthesis, and bioassay

“…We have successfully developed a variety of fundamental MUOs, such as mixing and reaction [18][19][20], two-and three-phase formations [15,[21][22][23][24][25][26][27][28][29], solvent extraction [15,[21][22][23][24][25][26][27][28], solid-phase extraction, and reaction on surfaces [30][31][32], heating [33,34], and cell culture [35] (Fig. 1).…”

“…The wavelength of the excitation beam is selected to coincide with an absorption band of the target molecule and that of the probe beam is chosen to be where sample solution has no absorption. For example, in determination of methyl red dye in water, cyclohexane and n-octanol, a 514 nm emission line of an argon ion laser and a 633 nm emission line of a heliumneon laser were used as excitation and probe beams, respectively [21]. The excitation beam was modulated at 1 kHz by an optical chopper.…”

“…For the microscale reaction, simple introduction of organic and aqueous phases into the microchannel provided a stable liquid/liquid interface, and the specific interfacial area had a larger value than those of the strong stirring and no stirring conditions for the macroscale reaction. Under our experimental conditions, the specific interfacial area (surface to volume ratio: S/V) provided by a microchannel with dimensions of 250 mm width, 100 mm depth, and 3 cm length was calculated to be 80 cm 21 . The reaction profiles and specific interfacial area are dependent on conversion for the reaction conditions (Fig.…”

Integration of Chemical and Biochemical Analysis Systems into a Glass Microchip

“…The components of MUO are shown in Fig. 2 mixing and reactions, 5-7 two-and three-phase formations, 8,9 solvent extraction, 10-14 solid-phase extraction, 15,16 heating, 17,18 and cell culture. 19 Moreover, the formation of a stable multiphase laminar flow network in microchannels has also been reported.…”

“…19 Moreover, the formation of a stable multiphase laminar flow network in microchannels has also been reported. 8,9,20 As shown in Fig. 2, MUOs utilizing aqueous-organic multiphase laminar flow, such as solvent extraction, are key technology in CFCP.…”