Distribution of Mercury in Rats Following Oral and Intravenous Administration of Mercuric Acetate and Phenylmercuric Acetate.

Prickett, C. S.; Laug, Edwin P.; Kunze, Frieda M

doi:10.3181/00379727-73-17752

Cited by 39 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large concentration of radiomercury was seen in the intestinal contents in the autoradio gram, suggesting that the intestinal tract might have been a route for the excretion of mer cury from the body. These findings are consistent with those findings obtained from rats by Pricket et al (17).…”

Section: Fig 8 Amount Of Radiomercury In Yolk Of Eggs Laid By a Laysupporting

confidence: 94%

An Autoradiographic Study on the Distribution of Mercury and Its Transfer to the Egg in the Laying Quail

1971

View full text Add to dashboard Cite

It has been reported that mercury was contained in the tissue of, and eggs laid by hens fed experimentaly seed grains treated with methyl mercury dicyandiamide (1, 2). In the field, it has also been pointed out the remarkably high mercury contents in seed-eating birds, such as pheasants, and predatory animals living on such birds, suggesting that it may be explained by the existence of alkyl mercury treated seed grains left in the field at the sowing time (3). In 1967, Teining (4) reviewed the pharmacological effect of methyl mercury dicyandiamide on the fowl Gallus gallus L. Some other investigators also studi ed the retention and movement of organic mercury compounds and their transfer to eggs in birds (5, 6).
The autoradiographic technique is one of the most useful methods to examine the body distribution of radioactive substances (7, 8). This technique has been employed actually to study the distribution of several radioactive compounds in the mouse and other small mammals (9-11), but not in any in the fowls.
The present paper reports a retention and movements of inorganic mercury, in the form of ²⁰³Hg-mercuric nitrate, and its transfer to egg in laying quail using a whole-body autoradiographic and radioisotope tracer techniques. METHODS Laying quails (Coturnix coturnix japonica, JQ-NIBS closed colony strain) 8 to 20 weeks old, weighing about 130 g, were supplied by the Nippon Institute for Biological Science. They were selected for the present experiments, as they had a history of having laid more than five eggs a week. Autorac/iograp/ry: Twelve laying quails were injected radioactive mercuric nitrate (-""Hg(NO.,),) into the cervical vein when they had an egg with hard shell in the uterus. The dose of-" `Hg(NO,,)2 for a quail employed in the autoradiographic experiment was 0.05 mg (equivalent to 40 1iCi) per 100 g of body weight in a volume of 0.1 ml. Its speci fic activity was 0.8 mCi per mg of mercury. This activity of mercury had no depressant effect on the laying. Each group of two birds of them was sacrificed 1, 24. 48, 96, 192, and 384 hours after injection of 20 "(HgNO:j),. Each bird was killed by inhalation with This work was partly supported by a research grant from the Ministry of Education, Japan. Fic. 3. Autoradiograms of laying quails injected intravenously 11'Hg(NO3)2 and taken 1, 24, 48, 96 hours after injection.

show abstract

Section: Fig 8 Amount Of Radiomercury In Yolk Of Eggs Laid By a Laysupporting

confidence: 94%

An Autoradiographic Study on the Distribution of Mercury and Its Transfer to the Egg in the Laying Quail

1971

View full text Add to dashboard Cite

show abstract

“…Pricketl el al. [23] reported that 2 h after a single intravenous dose of 120 ;xg of mercuric acetate, renal Hg level was 3 1 fjtg/g tissue whereas the same dose orally produced a level of 0.79 tj.g/g. 3.0 mg HgCU/kg body weight intravenously resulted in a renal Hg value at 3 h of approximately 1,500 u.g/g protein [27], almost three times the maximal values found in the present study.…”

Section: Discussionmentioning

confidence: 99%

Renal Function and Mercury Level in Rats with Mercuric Chloride Nephrotoxicity

Kirschbaum¹,

Sprinkle²,

Oken³

1980

Nephron

View full text Add to dashboard Cite

The levels of Hg++ in different subcellular compartments of rat kidney cortex were determined after a single subcutaneous injection of ²⁰³HgCl₂, 4.7 mg/kg body weight. By 30 min after injection, cortical Hg⁺⁺level was 46.3 ± 6.8 µg/g protein. A maximal cortical Hg^++· value of 429 ± 49 µg/g protein was reached 4 h after injection. Hg⁺⁺associated with the brush border membrane showed a progressive increase during the first 15 h after injection, but at each time interval was significantly less than cortical Hg⁺⁺ The 45-hour values for cortex and brush border were equivalent. No evidence for the presence in plasma or kidney tissue of free Hg⁺⁺ was obtained. Saline loading protected animals against the development of renal failure and resulted in significant lowering of cortical Hg⁺⁺ levels without an effect on blood Hg⁺⁺ concentrations.

show abstract

“…Although CH 3 Hg + does not accumulate in the kidney to the same degree as Hg 2+ , this form of Hg still accumulates in proximal tubular cells at significant levels and is capable of inducing significant detrimental effects (Friberg 1959; Magos et al 1985; Magos and Butler 1976; Magos et al 1981; McNeil et al 1988; Norseth and Clarkson 1970a, b; Prickett et al 1950). The majority of published evidence indicates that CH 3 Hg- S -Cys is the primary species of CH 3 Hg + taken up by renal epithelial cells.…”

Section: Transport Of Methylmercurymentioning

confidence: 99%

Mechanisms involved in the transport of mercuric ions in target tissues

2016

View full text Add to dashboard Cite

Mercury exists in the environment in various forms, all of which pose a risk to human health. Despite guidelines regulating the industrial release of mercury into the environment, humans continue to be exposed regularly to various forms of this metal via inhalation or ingestion. Following exposure, mercuric ions are taken up by and accumulate in numerous organs, including brain, intestine, kidney, liver, and placenta. In order to understand the toxicological effects of exposure to mercury, a thorough understanding of the mechanisms that facilitate entry of mercuric ions into target cells must first be obtained. A number of mechanisms for the transport of mercuric ions into target cells and organs have been proposed in recent years. However, the ability of these mechanisms to transport mercuric ions and the regulatory features of these carriers have not been characterized completely. The purpose of this review is to summarize the current findings related to the mechanisms that may be involved in the transport of inorganic and organic forms of mercury in target tissues and organs. This review will describe mechanisms known to be involved in the transport of mercury and will also propose additional mechanisms that may potentially be involved in the transport of mercuric ions into target cells.

show abstract

Distribution of Mercury in Rats Following Oral and Intravenous Administration of Mercuric Acetate and Phenylmercuric Acetate.

Cited by 39 publications

References 0 publications

An Autoradiographic Study on the Distribution of Mercury and Its Transfer to the Egg in the Laying Quail

An Autoradiographic Study on the Distribution of Mercury and Its Transfer to the Egg in the Laying Quail

Renal Function and Mercury Level in Rats with Mercuric Chloride Nephrotoxicity

Mechanisms involved in the transport of mercuric ions in target tissues

Contact Info

Product

Resources

About