Distribution of malathion in body tissues and fluids

Jadhav, R. K.; Sharma, Virendra K.; Rao, G. Gopala; Saraf, Anita; Chandra, Heeresh

doi:10.1016/0379-0738(92)90111-9

Cited by 29 publications

(12 citation statements)

References 5 publications

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“…For example, in one case of suicide, a blood malathion concentration of 1.9 µg/ml was detected [14]. Another fatal case with a survival time of 12 days showed initially a blood level of malathion of 23.9 µg/ml [15] and six fatal cases reported from India showed malathion concentrations which were in good accordance with our analytical findings (Table 1) [21].…”

Section: Discussionsupporting

confidence: 88%

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Fatal intoxication with omethoate

et al. 2002

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A case of suicide with the insecticide omethoate is reported. An 18-year-old apprentice gardener had ingested an unknown amount of omethoate. His body was found in his room lying in the storage space under his bed. The autopsy first showed multiple superficial incisions in the skin of his wrists, furthermore hemorrhagic pulmonary oedema, dilation of the right cardiac ventricle and oedema of the brain. The gastric mucosa was swollen and showed a dark brownish colour. An intensive, chemical-like smell rose from the corpse and organs. Toxicological analysis detected omethoate in cardiac blood (208 micro g/ml), urine (225 micro g/ml) and bile (524 micro g/ml), in the liver (341 micro g/ml) and kidneys (505 micro g/ml). In the gastric content the level was 48223 micro g/ml. The amount of the active AChE in peripheral blood serum was reduced to less than 0.2% of the normal level. To our knowledge no case of a fatal suicide by ingestion of omethoate has been reported in literature.

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Section: Discussionsupporting

confidence: 88%

“…Comparison to six fatal cases of malathion poisoning (medium value; lowest and highest level in brackets)[21] …”

mentioning

confidence: 99%

Fatal intoxication with omethoate

et al. 2002

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“…Here, the concentration of parathion ranged from 0.21 to 19.64 mg/L (mean: 2.90 mg/L). Jadhav et al reported that postmortem blood concentrations of malathion were between 175 and 517 mg/L in six cases of suspected poisoning [10]. We detected malathion with esfenvalerate, a pyrethroid pesticide, in three cases, and the concentration of malathion ranged from 0.35 to 1.32 mg/L (mean: 0.82 mg/L).…”

Section: Concentrations Of Chlorpyrifos Diazinon Malathion and Parmentioning

confidence: 62%

Postmortem blood concentrations of organophosphorus pesticides

Park

Lee

et al. 2009

Forensic Science International

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“…Another study reported that oral malathion doses were recovered in urine as MMA and MDA in approximately equal proportions (34–39%) and that DMTP was the predominant DAP metabolite (22–65%) (Krieger and Dinoff 2000). In a forensic study evaluating the distribution of malathion among tissues, unmetabolized malathion was detected in the blood and urine of all cases, with the blood level typically higher than that of urine by a factor of 2–3 (Jadhav et al 1992). Further, malathion was detected in all tissues autopsied, including the liver, spleen, kidney, lung, brain, and muscle, with the highest concentrations in the kidney (Jadhav et al 1992).…”

Section: Pharmacokineticsmentioning

confidence: 99%

Potential Uses of Biomonitoring Data: A Case Study Using the Organophosphorus Pesticides Chlorpyrifos and Malathion

Barr

Angerer²

2006

Environ Health Perspect

113

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BackgroundOrganophosphorus pesticides such as chlorpyrifos and malathion are widely used insecticides. They do not bioaccumulate appreciably in humans and are rapidly metabolized and excreted in the urine. In nonoccupational settings, exposures to these pesticides are typically sporadic and short-lived because the pesticides tend to degrade in the environment over time; however, dietary exposures may be more chronic. Biologic monitoring has been widely used to assess exposures, susceptibility, and effects of chlorpyrifos and malathion; thus, the information base on these compounds is data rich. For biomonitoring of exposure, chlorpyrifos and malathion have been measured in blood, but most typically their urinary metabolites have been measured. For assessing early effects and susceptibility, cholinesterase and microsomal esterase activities, respectively, have been measured.ObjectivesAlthough many biologic monitoring data have been generated and published on these chemicals, their interpretation is not straightforward. For example, exposure to environmental degradates of chlorpyrifos and malathion may potentially increase f urinary metabolite levels, thus leading to overestimation of exposure. Also, the temporal nature of the exposures makes the evaluation of both exposure and effects difficult. We present an overview of the current biomonitoring and other relevant data available on exposure to chlorpyrifos and malathion and the use of these data in various environmental public health applications.

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Distribution of malathion in body tissues and fluids

Cited by 29 publications

References 5 publications

Fatal intoxication with omethoate

Fatal intoxication with omethoate

Postmortem blood concentrations of organophosphorus pesticides

Potential Uses of Biomonitoring Data: A Case Study Using the Organophosphorus Pesticides Chlorpyrifos and Malathion

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