Distribution of Lymphocyte Subpopulations in Thyroid Glands of Human Autoimmune Thyroid Disease

Zha, Bingbing; Huang, Xiuyan; Lin, Jun; Liu, Jun; Hou, Yingyong; Guilong, WU

doi:10.1002/jcla.21674

Cited by 31 publications

(32 citation statements)

References 17 publications

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“…In addition, using immune staining we also found that CD3, CD4 and CD8 expression were mostly scattered throughout the tumor tissue while occasionally in clusters in the mesenchyme of tumor tissue. This lymphocyte distribution feature was similar with some other diseases …”

Section: Discussionsupporting

confidence: 89%

T cell receptor β‐chain repertoire analysis of tumor‐infiltrating lymphocytes in pancreatic cancer

Cui

Tian

et al. 2018

Cancer Science

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Pancreatic cancer is lethal due to lack of perceptible symptoms and effective treatment methods. Immunotherapy may provide promising therapeutic choices for malignant tumors like pancreatic cancer. Tumor‐infiltrating lymphocytes (TIL) in tumor mesenchyme could recognize peptide antigens presented on the surface of tumor cells. The present study aimed to test the relationship between the T cell receptor (TCR) β repertoire of the tumor and peripheral blood, and also to investigate the intra‐tumor spatial heterogeneity of the TCR β repertoire in pancreatic cancer. To the best of our knowledge, this is the first study to evaluate the clonal composition of TCR β repertoire in TIL across the spatial extent of pancreatic cancer. In this study, we studied 5 patients who were diagnosed with primary pancreatic cancer. Ultra‐deep sequencing was used to assess the rearrangement of the TCR β‐chain (TCR β) gene. HE staining and immunohistochemistry of CD3, CD4, CD8 and HLA class I were used to show histopathology and immune conditions macroscopically. TIL repertoire showed that different regions of the same tumor showed a greater number of repertoire overlaps between each other than between peripheral blood, which suggested that T cell clones in pancreatic cancer might be quite different from those in peripheral blood. In contrast, intra‐tumoral TCR β repertoires were spatially homogeneous between different regions of a single tumor tissue. Based on these results, we speculated that the cellular adaptive immune response in pancreatic cancer was spatially homogeneous; this may pave the way for immunotherapy for the treatment of pancreatic cancer patients.

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Section: Discussionsupporting

confidence: 89%

T cell receptor β‐chain repertoire analysis of tumor‐infiltrating lymphocytes in pancreatic cancer

Cui

Tian

et al. 2018

Cancer Science

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“…Thyroid autoimmunity is characterized by the existence of autoantigens like thyroglobulin (Tg), thyroid peroxidase (TPO), and so on, which may play crucial roles in the loss of self-tolerance resulting in disease pathogenesis [4]. Furthermore, thyroid autoimmunity may lead to infiltration of thyroid by T cells and B cells which are the cellular parts of adaptive immune response [5]. The T or B lymphocytic response prevails that can influence the manifested pathology [6].…”

Section: Introductionmentioning

confidence: 99%

Increased risk of thyroid autoimmunity in rheumatoid arthritis: a systematic review and meta-analysis

Pan

Shan

2015

Endocrine

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Thyroid autoimmunity, which is the most common immune-mediated disease, is frequently together with other organ- as well as nonorgan-specific autoimmune disorders. Meanwhile, rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disorder that mainly results in cartilage destruction as well as synovial joint inflammation, and both the adaptive and innate immune responses involve in the progression of this disease. Considering that autoimmune elements may be common characteristics of thyroid autoimmunity and RA, it is likely that both disorders may coexist within some patients. A great number of studies have researched whether an association between thyroid autoimmunity and RA exists; however, the results of these studies have been inconsistent. Most of these studies have included relatively small sample sizes, which have rendered them insufficiently powerful to determine whether there is a relationship between RA and thyroid autoimmunity. The main objective of this meta-analysis was to provide reliable estimates of the extent of any association between thyroid autoimmunity and RA by combining the primary data from all related studies. Literature databases, including the Embase, Medline, Web of Science, Chinese Wanfang, and CBM databases, were searched for studies published from January 1980 to May 2014, with a language restriction of English and Chinese. A total of 1,021 RA cases and 1,500 healthy controls were included in this study. From these data, the odds ratios (OR) and the corresponding 95 % confidence intervals (95 % CI) were calculated. The results of the meta-analysis showed that the prevalence of thyroid autoantibody positivity in patients with RA was higher than that in healthy controls (TgAb: OR 3.17, 95 % CI 2.24-4.49; TPOAb: OR 2.33, 95 % CI 1.24-4.39). The results of this meta-analysis suggest that thyroid autoimmunity is more prevalent in patients with RA than in the control population.

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“…T cells have several subpopulations such as CD4+ helper, CD8+ cytotoxic, and regulatory T cells (Tregs) (4). Tregs are a specialized subset of T cells that are co-expressed as CD4+ and CD25+, which have a central role for immune tolerance by downregulating the inflammatory response against self-antigens (5,6,7).…”

Section: Introductionmentioning

confidence: 99%

“…Tregs are a specialized subset of T cells that are co-expressed as CD4+ and CD25+, which have a central role for immune tolerance by downregulating the inflammatory response against self-antigens (5,6,7). These cells exert their regulatory activity on CD4+ T cells, CD8+ T cells, B cells, and dendritic cells (4). One of the important characteristics of Tregs is the expression of the forkhead/winged helix transcription factor FOXP3 molecules that serve as keys in the maintenance of peripheral tolerance and in controlling the immune response (2).…”

Section: Introductionmentioning

confidence: 99%

“…One of the important characteristics of Tregs is the expression of the forkhead/winged helix transcription factor FOXP3 molecules that serve as keys in the maintenance of peripheral tolerance and in controlling the immune response (2). FOXP3 is a key gene in the development of Treg cells and it commits naive T cells to become Treg cells (4). Recent studies suggest that a decrease in FOXP3+Treg cells number and/or function is often associated with autoimmunity (8,9).…”

Section: Introductionmentioning

confidence: 99%

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Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis

Şıklar¹,

Karatas²,

Doğu³

et al. 2016

Jcrpe

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Objective:It is suggested that vitamin D is one of the factors that can regulate the function of Treg cells. In this study, the relationships between Treg cells and vitamin D levels was investigated in pediatric chronic autoimmune thyroiditis (CAT) patients.Methods:Thirty-two children with CAT and 24 healthy subjects were studied. FOXP3 expressing CD4+CD25+high Foxp3+T cells were identified as Treg cells. At diagnosis, 25-hydroxycholecalciferol (25OHD3) levels were determined in all patients. FOXP3 expression was measured before and after vitamin D replacement therapy in patients having low levels of 25OHD3.Results:In the CAT patients, Treg cell levels did not differ from the control group, while the frequency of vitamin D deficiency was higher and FOXP3 molecule expression was lower. FOXP3 molecule expression significantly increased in CAT patients having vitamin D deficiency who were given vitamin D replacement.Conclusion:FOXP3 expression is decreased in pediatric CAT patients. This reduction seems to be associated with vitamin D levels. Vitamin D can play a role in enhancing natural Treg cell functions.

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Distribution of Lymphocyte Subpopulations in Thyroid Glands of Human Autoimmune Thyroid Disease

Cited by 31 publications

References 17 publications

T cell receptor β‐chain repertoire analysis of tumor‐infiltrating lymphocytes in pancreatic cancer

T cell receptor β‐chain repertoire analysis of tumor‐infiltrating lymphocytes in pancreatic cancer

Increased risk of thyroid autoimmunity in rheumatoid arthritis: a systematic review and meta-analysis

Regulatory T Cells and Vitamin D Status in Children with Chronic Autoimmune Thyroiditis

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