Distribution of limonoids in the rutaceae

Dreyer, David L.; Pickering, Michael V.; Cohan, Parviz

doi:10.1016/0031-9422(72)80036-0

Cited by 73 publications

(25 citation statements)

References 19 publications

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“…Hence, 29 was a novel limonoid named by Sun and coworkers as dictangustone A [122]. In a recent review article [90], limonoic acid (31) was erroneously reported as a limonoid isolated from Dictamnus dasycarpus although the original studies presented it as a neutral limonoid isomeric to limonin (1) [127,146]. Another recent review on the antioxidant activity of CLs has reported "millington acid 17-β-D-glucoside (NAG)" and "deacetylation millington acid 17-β-D-glucoside (DNAG)" as limonoids [31].…”

Section: Isolation and Identification Of Limonoids From The Citrus Genusmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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Citrus limonoids (CLs) are a group of highly oxygenated terpenoid secondary metabolites found mostly in the seeds, fruits and peel tissues of citrus fruits such as lemons, limes, oranges, pumellos, grapefruits, bergamots, and mandarins. Represented by limonin, the aglycones and glycosides of CLs have shown to display numerous pharmacological activities including anticancer, antimicrobial, antioxidant, antidiabetic and insecticidal among others. In this review, the chemistry and pharmacology of CLs are systematically scrutinised through the use of medicinal chemistry tools and structure-activity relationship approach. Synthetic derivatives and other structurally-related limonoids from other sources are include in the analysis. With the focus on literature in the past decade, the chemical classification of CLs, their physico-chemical properties as drugs, their biosynthesis and enzymatic modifications, possible ways of enhancing their biological activities through structural modifications, their ligand efficiency metrics and systematic graphical radar plot analysis to assess their developability as drugs are among those discussed in detail.

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Section: Isolation and Identification Of Limonoids From The Citrus Genusmentioning

confidence: 99%

The Chemistry and Pharmacology of Citrus Limonoids

et al. 2016

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“…The IR spectral data for compound (9) showed the disappearance of absorption at 1673 cm -1 and 1601 cm -1 corresponding to C=O group and for olefinic double bond, and exhibited absorption at 3487 cm -1 for N-H group. The reaction of chalcone (4a) with hydrazine hydrate and phenyl hydrazine can formed pyrazoline (10,11). The IR spectra of these compounds (Table 1) showed the disappearance of absorption of C=O group and olefinic double bond and exhibited absorption at 3359 cm -1 for N-H group.…”

Section: Scheme 5: the Mechanism Of Oxime Formationmentioning

confidence: 99%

“…Quinoline family compounds are widely used as a parent compound to make drug especially anti-malarial [1], anti-inflammatory [2,3], anti-bacterial [3,4,5], anti-fungal [6], anti-microbial agent [7], antitumor [8], analgesic [9]. The plant family have been known to be the rich source of quinoline alkaloids [10], pyranoquinoline alkaloids gained importance due to their several pharmacological activities like anticoagulant [11]. Several quinoline derivatives isolated from natural resources or prepared synthetically are significant with respect to medicinal chemistry and biomedical use.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of some new heterocyclic compounds derived from 2-Chloro-3-formyl quinoline

Ayoob¹,

Mohmood²

2013

J.Edu.Sci.

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“…Feronia limonia is a deciduous, slow-growing, erect tree belonging to family Rutaceae and subfamily Aurantioideae [6]. It is distributed in deciduous and arid landscapes of several countries in South Asia [7].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial and Antidiarrhoeal Activities of <i>Feronia limonia</i> Leaf Extract

Momin¹,

Khan²,

Rayhan³

et al. 2013

AJPS

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The present study was carried out to investigate possible antibacterial and antidiarrhoeal activities of ethanol extract of Feronia limonia leaves. Phytochemical analysis of the crude extract was performed to detect presence of different kinds of phytoconstituents. The antibacterial activity was investigated against four Gram positive and four Gram negative bacteria by using disc diffusion method. The plant extract showed moderate antibacterial activity against Gram positive bacteria namely Staphylococcus saprophyticus and Staphylococcus pyogenes and all tested Gram negative bacteria namely Escherichia coli, Shigella boydii, Shigella dysentery and Shigella flexneri in dose dependant manner. The results of castor oil-induced diarrhoeal study showed that Feronia limonia extract significantly reduced the severity & frequency of diarrhoea in mice at a higher dose of 500 mg/kg compared with the standard drug loperamide (25 mg/kg). The present study clearly supports the medicinal value of this plant. The overall results indicate the possibility of presence of some active principles in the plant extract possessing antibacterial and antidiarrhoeal actions.

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Distribution of limonoids in the rutaceae

Cited by 73 publications

References 19 publications

The Chemistry and Pharmacology of Citrus Limonoids

The Chemistry and Pharmacology of Citrus Limonoids

Synthesis of some new heterocyclic compounds derived from 2-Chloro-3-formyl quinoline

Evaluation of Antibacterial and Antidiarrhoeal Activities of <i>Feronia limonia</i> Leaf Extract

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Distribution of limonoids in the rutaceae

Cited by 73 publications

References 19 publications

The Chemistry and Pharmacology of Citrus Limonoids

The Chemistry and Pharmacology of Citrus Limonoids

Synthesis of some new heterocyclic compounds derived from 2-Chloro-3-formyl quinoline

Evaluation of Antibacterial and Antidiarrhoeal Activities of &lt;i&gt;Feronia limonia&lt;/i&gt; Leaf Extract

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Evaluation of Antibacterial and Antidiarrhoeal Activities of <i>Feronia limonia</i> Leaf Extract