Distribution of Kidney Kininogenases

Ag, Scicli; Carretero, O. A.; Nb, Oza; Ma, Schork

doi:10.3181/00379727-151-39142

Cited by 23 publications

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“…Three-quarters or more of renal kallikrein is found in the cortex (Nustad, 1970b;Scicli et al, 1976a). Nearly all the rest is in the outer strip of the outer medulla; little or no kallikrein is in the inner strip of outer medulla or the inner medulla (Nustad, 1970b).…”

Section: The Renal Kallikrein Systemmentioning

confidence: 99%

“…Nearly all the rest is in the outer strip of the outer medulla; little or no kallikrein is in the inner strip of outer medulla or the inner medulla (Nustad, 1970b). Isolated glomeruli contain low concentrations of kallikrein (Scicli et al, 1976a;Ward et al, 1977). These findings suggest that kallikrein originates from tubular epithelium of cortical nephron segments.…”

Section: The Renal Kallikrein Systemmentioning

confidence: 99%

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The renal kallikrein-kinin system.

Levinsky¹

1979

Circulation Research

155

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Section: The Renal Kallikrein Systemmentioning

confidence: 99%

Section: The Renal Kallikrein Systemmentioning

confidence: 99%

The renal kallikrein-kinin system.

Levinsky¹

1979

Circulation Research

155

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“…Figure 2 schematically shows the mechanism of kinins gener-The first kallikrein discovered was urinary kallikrein [30]. The isolated glomeruli have a small amount of kallikrein activity compared to the kallikrein concentration in the total cortex [80]. [71] demonstrated that rat kidney slices synthesized kallikrein.…”

Section: Origin Localization and Site Of Secretion Of The Kallimentioning

confidence: 99%

The renal kallikrein-kinin system in human and in experimental hypertension

Carretero

Scicli

1978

Klin Wochenschr

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The kallikrein-kinin system in the kidney is localized in the distal nephron, where it appears to be linked to processes that control water and electrolyte excretion. Some evidence exists that the effect of the renal kallikrein-kinin system is partially mediated by the release of prostaglandins. It has not yet been determined whether endogenous kinins affect the function of the nephron directly or indirectly by changes in renal blood flow distribution. Further, a number of studies in animals and humans indicates that kallikrein excretion is decreased in most types of hypertension, with the exception of hypertension caused by an excess of mineralocorticoids (where kallikrein is increased). In rats susceptible to the hypertensive effect of salt, kallikrein is conspicuously decreased. In renal diseases, urinary kallikrein excretion is also decreased. Finally, it still needs to be determined whether or not low kallikrein excretion is a pathogenetic factor in hypertension and renal diseases.

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Renal Blood Flow

Hura

Stein

1992

Comprehensive Physiology

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The sections in this article are: Measurement of Renal Blood Flow Total Renal Blood Flow Regional Cortical Blood Flow Medullary Blood Flow Renal Microcirculation Control of Renal Circulation Intrinsic Factors Extrinsic Control Renovascular Resistance Changes in Selected Pathophysiological States Extracellular Volume Expansion Hemorrhagic Hypotension Acute Renal Failure

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Distribution of Kidney Kininogenases

Cited by 23 publications

References 0 publications

The renal kallikrein-kinin system.

The renal kallikrein-kinin system.

The renal kallikrein-kinin system in human and in experimental hypertension

Renal Blood Flow

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