Distribution of isoaccepting tRNAs and codons for proline and glycine in collagenous and noncollagenous chicken tissues

Ouenzar, Bouchra; Agoutin, Bernadette; Reinisch, F; Weill, Dominique; Périn, François; Keith, Gérard; Heyman, T.

doi:10.1016/0006-291x(88)90498-6

Cited by 8 publications

(2 citation statements)

References 31 publications

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“…Similar situations have been reported for human involucrin gene (Eckert and Green 1986) and Balbiani Ring genes (Hoog et al 1988). It was also reported that the "aberrant" repeats are often observed toward the ends of tandem arrays ( Quenzar et al (1988) studied the relationship between the isoaccepting tRNA distribution and codon bias in tendon collagen of chicken. They noted that there is a relative increase in the levels of tRNAIGG Pr° (100%) and tRNAGcc Gly (40%) in tendon as compared to other tissues, indicating a specialization of the tRNA population for collagen synthesis.…”

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Highly repetitive structure and its organization of the silk fibroin gene

Mita¹,

Ichimura²,

1994

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We have sequenced a number of cDNAs representing the Bombyx mori silk fibroin heavy chain transcript. These reveal that the central region of the fibroin gene is composed of alternate arrays of the crystalline element a and the noncrystalline element b. The core region is partitioned by a homogeneous nonrepetitive amorphous domain of around 100 bp in length. The element a is characterized by repeats of a highly conserved 18-bp sequence coding for perfect repeats of the unit peptide Gly-Ala-Gly-Ala-Gly-Ser. The element b is composed of repeats of a less-conserved 30-bp sequence which codes for a peptide similar to that in element a except in that (1) Ser is replaced by Tyr and (2) there are irregular substitutions of Ala to Val or Tyr. Therefore, the structure of the fibroin gene core consists of three-step higher-order periodicities. Heterogeneities in numbers of repeats are observed in each step of periodicity. Boundary sequence appeared in each periodicity to be quite homogeneous. Sequence analysis indicates that the unit sequences of elements a and b have homology to those of recombination hotspots reported in other genes and a recombination event may frequently occur between the misaligned sister chromatids, resulting in heterogeneities in repeat numbers and duplication or deletion of repetitive sequences. The repetitive superstructure of the fibroin gene may have been a result of continuous unequal crossovers in a primordial gene during evolution. A couple of important features of the fibroin protein were proved by the present nucleotide sequencing.(ABSTRACT TRUNCATED AT 250 WORDS)

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Highly repetitive structure and its organization of the silk fibroin gene

Mita¹,

Ichimura²,

1994

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“…Μελέτες σε ιστούς που συνθέτουν κολλαγόνο τύπου Ι δείχνουν ότι αυτοί οι ιστοί αυξάνουν την χρήση των μορίων tRNA Gly , σε σχέση με αυτούς που δεν συνθέτουν 93,94 .…”

Section: κολλαγόνο και κολλαγόνο τύπου ιunclassified

Εφαρμογή Συστήματος Διοστικών Υπέρηχων Στη Διεπιφάνεια Οστού-Τένοντα Και Στα Κατάγματα Μακρών Οστών. Πειραματική Και Κλινική Μελέτη

Παπαθεοδώρου¹

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Nucleic acid composition, codon usage, and the rate of synonymous substitution in protein-coding genes

Ticher

Graur

1989

J Mol Evol

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Based on the rates of synonymous substitution in 42 protein-coding gene pairs from rat and human, a correlation is shown to exist between the frequency of the nucleotides in all positions of the codon and the synonymous substitution rate. The correlation coefficients were positive for A and T and negative for C and G. This means that AT-rich genes accumulate more synonymous substitutions than GC-rich genes. Biased patterns of mutation could not account for this phenomenon. Thus, the variation in synonymous substitution rates and the resulting unequal codon usage must be the consequence of selection against A and T in synonymous positions. Most of the variation in rates of synonymous substitution can be explained by the nucleotide composition in synonymous positions. Codon-anticodon interactions, dinucleotide frequencies, and contextual factors influence neither the rates of synonymous substitution nor codon usage. Interestingly, the nucleotide in the second position of codons (always a nonsynonymous position) was found to affect the rate of synonymous substitution. This finding links the rate of nonsynonymous substitution with the synonymous rate. Consequently, highly conservative proteins are expected to be encoded by genes that evolve slowly in terms of synonymous substitutions, and are consequently highly biased in their codon usage.

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Distribution of isoaccepting tRNAs and codons for proline and glycine in collagenous and noncollagenous chicken tissues

Cited by 8 publications

References 31 publications

Highly repetitive structure and its organization of the silk fibroin gene

Highly repetitive structure and its organization of the silk fibroin gene

Εφαρμογή Συστήματος Διοστικών Υπέρηχων Στη Διεπιφάνεια Οστού-Τένοντα Και Στα Κατάγματα Μακρών Οστών. Πειραματική Και Κλινική Μελέτη

Nucleic acid composition, codon usage, and the rate of synonymous substitution in protein-coding genes

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