Distribution of intracardiac neurones and nerve terminals that contain a marker for nitric oxide, NADPH-diaphorase, in the guinea-pig heart

Tanaka, Kōichi; Hassall, C. J. S.; Burnstock, Geoffrey

doi:10.1007/bf00312831

Cited by 63 publications

(24 citation statements)

References 31 publications

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“…All three isoforms of NOS are expressed within various cell types of the heart [101,103]. NOS 1 has been identified in cholinergic, sympathetic and nonadrenergic, non-cholinergic nerve terminals of the guinea pig heart [104]. NOS 2 is found in virtually all myocardial cell types following stimulation with inflammatory cytokines [105].…”

Section: Bars No and The Heartmentioning

confidence: 99%

β-Adrenergic receptors and nitric oxide generation in the cardiovascular system

Queen

Ferro

2006

Cell. Mol. Life Sci.

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Nitric oxide plays a crucial role in cardiovascular homeostasis, with important vasodilatory, anti-thrombotic and anti-atherogenic properties. Beta-adrenergic receptors (betaARs), present on a wide variety of cardiovascular cells, including vascular endothelial cells, platelets, cardiac myocytes and leukocytes, have long been established as key players in maintaining cardiovascular homeostatic control. During the last few years a wealth of evidence has emerged which directly links stimulation of these cardiovascular betaARs to nitric oxide (NO) generation, suggesting a new and important mechanism of adrenergic control of cardiovascular function. This review explores the cardiovascular cell systems in which this coupling of betaARs and NO occurs, the intracellular signalling and regulatory mechanisms involved and the abnormalities in betaAR-NO oxide coupling found in cardiovascular disease states.

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Section: Bars No and The Heartmentioning

confidence: 99%

β-Adrenergic receptors and nitric oxide generation in the cardiovascular system

Queen

Ferro

2006

Cell. Mol. Life Sci.

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“…Only 4% of intrinsic neurones in the rat heart, but more of these neurones in the guinea-pig, are NOS-immunoreactive and labelled neuronal processes are associated with intracardiac ganglia, nodal tissues, the coronary vasculature and myocardium Klimaschewski et al 1992;Tanaka et al 1993a;Sosunov et al 1995). At the electron-microscopic level, synapses between NOS-immunoreactive nerve profiles and unlabelled intracardiac neurones have been observed (Tanaka et al 1993b); however, the ultrastructural characteristics of the NOS/NADPH-diaphorase-containing intracardiac neuronal cell bodies have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Nitric oxide synthase-containing neurones and nerve fibres within cardiac ganglia of rat and guinea-pig: an electron-microscopic immunocytochemical study

Sosunov

Hassall

Loesch

et al. 1996

Cell and Tissue Research

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The nitric oxide synthase-immunoreactivity and NADPH-diaphorase activity of intracardiac neurones in the rat and guinea-pig was studied at the ultrastructural level. While some nitric oxide synthase-containing intracardiac neurones were very heavily labelled, with electron-dense immunoprecipitate distributed throughout the neuronal cell bodies and their processes, most of the labelled neurones exhibited a lighter and more patchy distribution of nitric oxide synthase-immunoreactive material. Synapses made by nitric oxide synthase-negative nerve fibres with labelled intracardiac neurones were seen. Conversely, many nitric oxide synthase-containing nerve fibres that made synaptic contacts with unlabelled intracardiac neurones were also observed. Some small granule-containing cells were nitric oxide synthase-immunoreactive and were associated with unlabelled nerve terminals, while non-immunoreactive small granule-containing cells that were innervated by nitric oxide synthase-immunoreactive nerves were also seen. Small patches of osmiophilic electron-dense material were observed in the cytoplasm of NADPH-diaphorase-positive intracardiac neurones. This is the first description of the ultrastructural distribution of nitric oxide synthase-immunoreactivity and NADPH-diaphorase activity in a subpopulation of intracardiac neurones of rat and guinea-pig heart and provides further evidence in support of a role for nitric oxide in the local control of the heart by intrinsic neurones.

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“…1, 2). In addition, short-time (''puffs'') and/or short-distance diffusion of NO signal ''clouds'' at nitrergic synapses or varicose neureffector junctions at Grozdanovic et al, 1992;Morris et al, 1993;Santer and Symons, 1993;Ceccatelli et al, 1994;Alm et al, 1995;Tanaka and Chiba, 1994Ciliary/Otic Yamamoto et al, 1993Sphenopalatine Minami et al, 1994Zhu et al, 1997Superior cervical Dun et al, 1995Handa et al, 1996 Celiac Furness andEkblad et al, 1994Mesenteric Domoto et al, 1995Luckensmeyer andKeast, 1996 Hypogastric Warburton andElfvin et al, 1997Pelvic Jen et al, 1996 Intramural/Enteric ganglia Heart Klimaschewski et al, 1992;Tanaka et al, 1993;Sousunov et al, 1996;Sawada et al, 1997Bronchoalveolar system Kobzik et al, 1993Dey et al, 1993Gastrointestinal tract Belai et al, 1992Aimi et al, 1993;Talmage and Mawe, 1993;Furness et al, 1994;Singaram et al, 1994Urogenital tract Keast, 1992McNeill et al, 1992;Grozdanovic et al, 1994;Soinila, 1995a Endocrine tissue Pancreas Shimosegawa et al, 1992;Wörl et al, 1994;Kirchgessner et al, 1994Adrenal gland Afework et al, 1992, 1995Dun et al, 1993;…”

Section: No: Short-term and Spatially Acting Cotransmitter In Autonommentioning

confidence: 97%

Nitric oxide and target-organ control in the autonomic nervous system: Anatomical distribution, spatiotemporal signaling, and neuroeffector maintenance

Blottner

1999

J. Neurosci. Res.

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Recent neuroanatomical studies, neurochemical coding and physiological findings of multiple cotransmitter actions and/or receptor patterns, and the characterization of synaptic molecules and nitrergic (NOergic) signaling mechanisms may help for a better understanding of target-organ control in the autonomic nervous system. Thus, nitric oxide (NO) synthase, which generates the freely diffusible and short-lived messenger NO and expression of neurotrophic proteins (e.g., neurotrophins, glial cell-line-derived neurotrophic factor, fibroblast growth factors) in autonomic neural pathways or target organs suggest unique actions in autonomic neurotransmission. In central NOergic pathways, NO may serve as spatial (volume) messenger within hierarchically ordered autonomic neuron pools and convergent/divergent pathways for synchronized autonomic outflow. Likewise, NO modulates intraganglionic and interaxonal transmission and postganglionic activity including long-term potentiation. In the visceral targets, NO appears to be a spatial modulator in local intrinsic networks or at varicose terminals. In endocrine glands, NO possibly acts as synaptic coactivator or inhibitor, as a cotransmitter affecting stimulus-coupled exocytosis, or as a local vasoactive signal. The short-term neural messenger NO may also induce diffusible target-derived long-term neurotrophic signals, thereby supporting neuroeffector maintenance and plasticity, if not synaptic efficacy, in autonomic target-organ control.

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Distribution of intracardiac neurones and nerve terminals that contain a marker for nitric oxide, NADPH-diaphorase, in the guinea-pig heart

Cited by 63 publications

References 31 publications

β-Adrenergic receptors and nitric oxide generation in the cardiovascular system

β-Adrenergic receptors and nitric oxide generation in the cardiovascular system

Nitric oxide synthase-containing neurones and nerve fibres within cardiac ganglia of rat and guinea-pig: an electron-microscopic immunocytochemical study

Nitric oxide and target-organ control in the autonomic nervous system: Anatomical distribution, spatiotemporal signaling, and neuroeffector maintenance

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