Distribution of Integrins ??6 and ??4 in the Rabbit Corneal Epithelium After Anterior Keratectomy

Immunopathogenesis of conjunctival remodelling in vernal keratoconjunctivitis

“…Our observations are consistent with reports that a3, a6, b1, and b4 integrin subunits were expressed only on the basal layer of proliferating keratinocytes in normal skin, 16,[31][32][33][34] and on the basal epithelial cells in normal cornea. [35][36][37] In fact, the integrin a6 subunit (CD49f) is known to be associated with hemidesmosomes of basal keratinocytes. 32 Compared to normal conjunctiva, the conjunctiva from patients with active VKC showed strong expression of the integrin a3 and a6 subunits on the basal and suprabasal epithelial cells.…”

Effects of transforming growth factor β on corneal epithelial and stromal cell function in a rat wound healing model after excimer laser keratectomy

“…In the process of corneal stromal wound healing, the increase of types III, IV, and VII collagen, fibronectin, laminin, proteoglycan, tenascin, keratan sulfate, and hyaluronic acid has been reported [2,3,33,38]. The corneal wound healing process is related to the integrin expression of corneal epithelial cells [11,17,18,29,30,35,36]. Each step is speculated to be regulated by many growth factors and cytokines, including EGF, KGF, HGF, FGF, VEGF, and TGF-a [7,19,32,39].…”

Alterations of epithelial adhesion molecules and basement membrane components in lattice corneal dystrophy (LCD)

“…The corneal epithelium adheres to the underlying Bowman's layer through a series of linked structures termed collectively the "adhesion complex" [5], which is composed of intermediate filaments, hemidesmosome, anchoring filaments, basement membrane, and anchoring fibrils [6]. The purpose of this study was to investigate potential pathological correlates of delayed epithelial healing in LCD by analyzing the distribution of integrins and basement membrane components by immunhistochemistry, and of hemidesmosomes by transmission electron microscopy (TEM) in control corneas and corneas with different localisation of amyloid deposits in LCD.…”