Distribution of IgG subclass anti-nuclear antibodies (ANAs) in systemic lupus erythematosus

Zeng, Yanli; Zhou, Yan; Chen, Qinggui; Huang, Qinghe; Yuan, Lin; Wang, Xuelian; Wang, Jia Jia; Li, Jiang; Xiao, Yun

doi:10.1177/0961203321995242

Cited by 8 publications

(5 citation statements)

References 25 publications

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“…Autoreactive antibody titers in autoimmune disease patients are known to fluctuate [ 32 , 33 ] and their isotypes are altered as the disease progresses. For example, isotype changes to IgG4 without the ability of complement activation and antibody‐dependent cell cytotoxicity could reduce disease progression [ 34 , 35 , 36 ]. Therefore, there are attempts to use it as a prognostic biomarker [ 37 , 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire

et al. 2022

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B cells recognize antigens via membrane‐expressed B‐cell receptors (BCR) and antibodies. Similar human BCR sequences are frequently found at a significantly higher frequency than that theoretically calculated. Patients infected with SARS‐CoV2 and HIV or with autoimmune diseases share very similar BCRs. Therefore, in silico reconstitution of BCR repertoires and identification of stereotypical BCR sequences related to human pathology have diagnostic potential. Furthermore, monitoring changes of clinically significant BCR sequences and isotype conversion has prognostic potential. For BCR repertoire analysis, peripheral blood (PB) is the most convenient source. However, the optimal human PB volume for in silico reconstitution of the BCR repertoire has not been studied in detail. Here, we sampled 5, 10, and 20 mL PB from the left arm and 40 mL PB from the right arm of two volunteers, reconstituted in silico PB BCR repertoires, and compared their composition. In both volunteers, PB sampling over 20 mL resulted in slight increases in functional unique sequences (FUSs) or almost no increase in repertoire diversity. All FUSs with a frequency above 0.08% or 0.03% in the 40 mL PB BCR repertoire were detected even in the 5 mL PB BCR repertoire from each volunteer. FUSs with a higher frequency were more likely to be found in BCR repertoires from reduced PB volume, and those coexisting in two repertoires showed a statistically significant correlation in frequency irrespective of sampled anatomical site. The correlation was more significant in higher‐frequency FUSs. These observations support the potential of BCR repertoire analysis for diagnosis.

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Section: Discussionmentioning

confidence: 99%

Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire

et al. 2022

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“…Significant anti-nuclear IgG4 antibody titers (ANA-IgG4) have been detected in SLE patients, and it has been suggested that the effect of these antibodies on complement consumption and the production of proinflammatory cytokines may play a role in inhibiting the progression of SLE. The presence of anti-dsDNA IgG4 antibodies was also reported and was associated with skin lesions and kidney involvement in patients with SLE ( 74 ). Pan et al.…”

Section: Other Rheumatic Diseases and Igg4mentioning

confidence: 94%

“…The role of IgG4 in helmints infection is still analyzed. Essentially, two possible mechanisms are proposed that can lead to the inhibition of IgE-mediated immunity and resistance to helmints ( 74 , 76 ). One is associated with the inhibition of a switch in plasma cell production from IgM via IgG4 to IgE.…”

Section: Other Rheumatic Diseases and Igg4mentioning

confidence: 99%

The Role of IgG4 in Autoimmunity and Rheumatic Diseases

2022

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The distinguishing of the IgG4-related disease (IgG4-RD) from among other rheumatic diseases has brought attention to the IgG4 subclass of immunoglobulins. It is the least numerous subclass among immunoglobulins G. In general, IgG4 is considered to be non-inflammatory and tolerance inducing, due to its unique structure. However, in IgG4-RD this antibody plays a pathogenic role in activation of the fibrinogenesis and of the inflammatory process; there are also suggestions that it may be a marker of an abnormal inflammatory response. The importance of IgG4 for the pathogenesis of allergic diseases, with a vital role of its ratio to immunoglobulin E (IgE/IgG4 ratio), has been known for years. The role of IgG4 in the course and pathogenesis of rheumatic diseases is still being researched and is not yet fully understood. Increased IgG4 levels have been revealed in rheumatoid arthritis, although no clear link between this phenomenon and disease activity has been demonstrated. There are articles on the potential importance of IgG4 concentration (of both elevated and decreased serum levels) in Sjogren’s syndrome. Additionally, anti-nuclear IgG4 antibody significant titers have been detected in SLE patients, and it has been suggested that the effect of these antibodies on complement consumption and the production of proinflammatory cytokines may play a role in inhibiting the progression of SLE. IgG4 plays a role in autoimmune diseases other than rheumatic diseases, such as pemphigus, bullous pemphigoid, idiopathic membranous glomerulonephritis, or myasthenia gravis, but also in helmints infections. Research shows the importance of IgG4 in malignancy of neoplasms. Melanoma cells are known to stimulate IgG4 production through a modified Th2-based inflammatory response. The role of this immunoglobulin in cholangiocarcinoma is also considered as possible. The aim of this review article is to discuss the current knowledge of IgG4 not only from the perspective of the IgG4-RD but also from a point of view of other autoimmune diseases with particular emphasis on rheumatic diseases.

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“…[62,63] Anti-dsDNA IgG4 antibodies were detected and found to be linked with cutaneous manifestations and renal impairment in individuals diagnosed with SLE. [64] Diverse findings could arise from varying disease stages and methodologies employed across disparate research facilities. However, each of these studies demonstrated the participation of IgG4 in certain traditional non-IgG4-RD conditions.…”

Section: Igg4 In Slementioning

confidence: 99%

The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy

Liu,

Wang,

et al. 2024

J Biochem & Molecular Tox

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Immunoglobulin (Ig) G4 has a distinctive nature, and its involvement in autoimmune disorders is a subject of ongoing debate and uncertainty. A growing body of evidence indicates that IgG4 may play a pathogenic role in the development of systemic lupus erythematosus (SLE). The IgG4 autoantibodies have the capability to bind autoantigens in a competitive manner with other Ig classes, thereby forming immune complexes (ICs) that are noninflammatory in nature. This is due to the low affinity of IgG4 for both the Fc receptors and the C1 complement molecule, which results in a diminished inflammatory response in individuals with SLE. The present study aims to elucidate the significance of IgG4 in SLE. The present discourse pertains to the nascent and suggested modalities through which IgG4 might participate in the pathogenesis of SLE and the potential ramifications for therapeutic interventions in SLE.

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Distribution of IgG subclass anti-nuclear antibodies (ANAs) in systemic lupus erythematosus

Cited by 8 publications

References 25 publications

Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire

Optimization of peripheral blood volume for in silico reconstitution of the human B‐cell receptor repertoire

The Role of IgG4 in Autoimmunity and Rheumatic Diseases

The role of IgG4 in systemic lupus erythematosus: Implications for pathogenesis and therapy

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