Distribution of <i>Lewis</i> and <i>Secretor</i> polymorphisms and corresponding <scp>CA</scp>19‐9 antigen expression in a Chinese population

Guo, Meng; Luo, Guopei; Lu, Renquan; Shi, Weizhong; He, Cheng; Lei, Yu; Jin, Kaizhou; Yang, Chao; Wang, Zhengshi; Jiang, Long; Xu, Jin; Ni, Quanxing; Liu, Chen; Yu, Xianjun

doi:10.1002/2211-5463.12278

Cited by 45 publications

(41 citation statements)

References 37 publications

(94 reference statements)

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“…We found that 76.7% mothers were Se+Le+ phenotype, 17.2% were Se-Le+, 4.3% were Se+Le-, and just 2 (1.7%) were Se-Le-. The result was similar with a genes polymorphisms study in China [41], which revealed that 9.8% of individuals were the Le-type and 22.5% were the Se-type.…”

Section: Secretor and Lewis Phenotypesupporting

confidence: 90%

Neutral Human Milk Oligosaccharides Are Associated with Multiple Fixed and Modifiable Maternal and Infant Characteristics

Wang

Zhao

et al. 2020

Nutrients

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We aimed to identify if maternal and infant factors were associated with neutral human milk oligosaccharides (HMOs) variability and examined the associations between HMOs concentration and infant growth and disease status in healthy Chinese mothers over a 6-month lactation period. We recruited mothers and their full-term infants as our subjects. At 1–5 days, 8–14 days, 4 weeks, and 6 months postpartum, all participants were interviewed to collect breast milk samples, obtain follow-up data and measure infant length and weight at their local hospital. A total of 23 neutral HMOs were analyzed by high performance liquid chromatography (HPLC)- mass spectrometer (MS). Secretor and Lewis phenotype were determined by the concentration of 2′-fucosyllactose (2′-FL) and Lacto-N-fucopentaose (LNFP)-II. The associations between maternal and infant factors with HMOs concentrations were investigated. A total of 464 human breast milk samples were collected from 116 mothers at four different time points. In total, 76.7% mothers were found to be Secretor and Lewis positive phenotype (Se+Le+), 17.2% were Se-Le+, 4.3% were Se+Le-, and 1.7% were Se-Le-. Several individual HMOs, including 2′-FL, Lactodifucotetraose (LDFT), LNFP-I were determined by Secretor phenotype. Most individual HMOs decreased at the later stage of lactation, except 3′-FL. We suggest that Secretor phenotype and lactation stage could influence most of the neutral HMOs. Concentrations of specific HMOs may be associated with maternal age, allergic history, pre-pregnancy body mass index (BMI), parity, delivery mode, infant gestational age and gender.

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Section: Secretor and Lewis Phenotypesupporting

confidence: 90%

Neutral Human Milk Oligosaccharides Are Associated with Multiple Fixed and Modifiable Maternal and Infant Characteristics

Wang

Zhao

et al. 2020

Nutrients

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“…The sensitivity in detecting pancreatic cancer is ~80% for CA19-9 (9). In the population, ~5-10% of individuals are Lewis antigen negative, with no or low secretion of CA19-9 (10). In a previous study, we showed that Lewis-negative patients had poorer outcome than Lewis-positive patients (11).…”

Section: Introductionmentioning

confidence: 90%

Lewis antigen‑negative pancreatic cancer: An aggressive subgroup

et al. 2020

Self Cite

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Carbohydrate antigen 19-9 (CA19-9) is the most important biomarker for pancreatic cancer. Approximately 5-10% of individuals are Lewis antigen negative with scarce secretion of CA19-9 and fucosylation deficiency. However, the characteristics of Lewis-negative pancreatic cancer are unidentified. Clinicopathological characteristics of 853 patients with pancreatic cancer were examined. Pancreatic cancer cell lines were sequenced for Lewis status. Morphological and molecular features of pancreatic cancer cells were compared. Orthotopic animal modes were established. Lewis-negative patients had poorer outcome (P<0.001), higher metastatic rate (P=0.004), lower CA19-9 expression (P<0.001) and higher MUC16 expression (P<0.001) than Lewis-positive patients. Lewis-negative cells (CaPan-1, MiaPaCa-2 and Panc-1) showed a shuttle shape with scarce pseudopods. Overall, Lewis-negative cells had higher proliferation rate, higher migration ability, lower fucosylation, lower CA19-9 expression and higher MUC16 expression than Lewis-positive cells (BxPC-3, SU8686, SW1990). Lewis-negative cell line MiaPaCa-2 corresponded to larger orthotopic tumor than Lewis-positive cells SU8686. Potential proteoglycans were identified in Lewis-positive cancer, including EGFR, HSPG2, ADAM17, GPC1, ITGA2, CD40, IL6ST and GGT1. Therefore, Lewis-negative pancreatic cancer is an aggressive subgroup with special clinical and molecular features.

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“…Our results exhibited no significant association between FUT2/3 gene SNP genotypes and CA19‐9 expression. FUT2/3 enzyme activities may influence CA19‐9 serum levels . However, a few reports have examined the association between FUT2/3 polymorphisms and GC .…”

Section: Discussionmentioning

confidence: 99%

“…Fucosyltransferases 2/3 are genes that encode fucosyltransferases 2/3, and their sequences were first reported by Kelly et al . A recent study demonstrated that the FUT2/3 genotypes are associated with cancer risk as well as with CA19‐9 synthesis and secretion . Individuals lacking FUT3 and/or FUT2 activity would exhibit CA19‐9 tissue or serum levels under the normal range .…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19‐9 expression occurring in elderly individuals: An autopsy study

Wang

Matsuda

Nonaka

et al. 2019

Pathology International

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gastric cancer (GC) remains obscure. Therefore, the current study aimed to clarify the clinicopathological value of CA19-9 in GC utilizing autopsy cases.We examined the expression of CA19-9 and mucin core proteins in GC immunohistochemically, and analyzed serum CA19-9 levels and clinicopathological variables or complications. We also investigated whether fucosyltransferases 2 and 3 (FUT2/3) allelic variants influence CA19-9 expression in GC. Compared to GC cases with negative CA19-9 expression (tCA19-9-N), those with positive CA19-9 expression (tCA19-9-P) demonstrated significant differences in characteristic features such as lymph node and distant organ metastases, lymphatic and venous permeation, and higher Tumor, Node, Metastasis (TNM) stages. Moreover, compared to GC cases with low serum CA19-9 levels (sCA19-9-L), those with high serum CA19-9 levels (sCA19-9-H) were related to venous permeation, higher proportion of lymph node and distant organ metastases, and higher TNM stages.Both tCA19-9-P GC and sCA19-9-H GC cases were significantly associated with coagulation abnormalities. sCA19-9-H GC cases correlated significantly with MUC1 and MUC5AC expression. FUT2/3 genotypes were not associated with CA19-9 expression in GC. These results suggest that CA19-9 can predict the risk of lymph node and distant metastases as well as of coagulation abnormalities.

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Distribution of Lewis and Secretor polymorphisms and corresponding CA19‐9 antigen expression in a Chinese population

Cited by 45 publications

References 37 publications

Neutral Human Milk Oligosaccharides Are Associated with Multiple Fixed and Modifiable Maternal and Infant Characteristics

Neutral Human Milk Oligosaccharides Are Associated with Multiple Fixed and Modifiable Maternal and Infant Characteristics

Lewis antigen‑negative pancreatic cancer: An aggressive subgroup

Clinicopathological characteristics of gastric cancer with carbohydrate antigen 19‐9 expression occurring in elderly individuals: An autopsy study

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