Distribution of
 emm
 Types and Genetic Characterization of the
 mgc
 Locus in Group G
 Streptococcus dysgalactiae
 subsp.
 equisimilis
 from a Hospital in Northern Taiwan

Tseng, Sung-Pin; Yang, Lin; Tsai, Jui‐Chang; Hsueh, Po-Ren; Chen, Hsiao-Jan; Hung, Wei‐Chun; Teng, Lee‐Jene

doi:10.1128/jcm.00444-10

Cited by 15 publications

(10 citation statements)

References 15 publications

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“…The prevalence of emm types stG485.0 and stG166b was even higher in the invasive group (23.2 % and 16.2 %, respectively). These results are in accordance with other studies: emm types stG485.0 and stG6.1 were reported as being the most common types identified among patients with group G bacteremia in a hospital setting in Jerusalem [6], in Chennai, south India [16] and in a hospital setting in Northern Taiwan [17]. The total high prevalence of those emm types in all other isolates (noninvasive and carriage) indicates the likelihood of a possible reservoir for severe infections.…”

Section: Discussionsupporting

confidence: 92%

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Halperin

Levine

Korenman

et al. 2016

Eur J Clin Microbiol Infect Dis

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Beta-hemolytic group G streptococci (GGS) are increasingly recognized as a source of substantial morbidity, causing mild to severe sporadic infections as well as outbreaks. The purpose of this study was to determine the genetic diversity and antibiotic resistance of GGS in Israel in order to aid in prevention and control. A total of 325 GGS isolates were collected in Israel between 2007 and 2011 from three determined settings: (1) carriage (n = 60), an observational longitudinal carriage study in the IF, (2) non-invasive (n = 166), clinical sporadic and epidemic non-invasive cases in the IDF, and (3) invasive (n = 99) cases of bacteremia collected during this period in Israel from a similar age group, at the national Streptococcal Reference Center. All isolates were characterized genetically and by their antibiotic-resistance profile. emm typing revealed 35 distinct types and subtypes among 228 S. dysgalactiae subsp. equisimilis (SDSE) isolates, with high genetic diversity. An additional 97 GGS were identified as Streptococcus anginosus (SAG). The proportion of SDSE was higher in the invasive (100 %) and non-invasive (63.8 %) isolates compared to the carriage ones (38.3 %). Clindamycin, erythromycin, azithromycin and tetracycline resistance was detected in 6.6 %, 8.6 %, 9.7 % and 37.6 % of isolates, respectively. Overall, the most resistant isolates were in the invasive group and the fewest were in the SAG group. Considerable genetic diversity and common antibiotic resistance were revealed among GGS strains which differed according to the epidemiologic settings. Further clinical, epidemiological and basic research of GGS as a pathogen is warranted.

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Section: Discussionsupporting

confidence: 92%

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Halperin

Levine

Korenman

et al. 2016

Eur J Clin Microbiol Infect Dis

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“…The prevalence of emm types in SDSE displayed area variation. The emm distribution among isolates in central Taiwan showed quite diverse from northern Taiwan, China, and Finland . For example, the most prevalent type, stG10.0 , in this study was not a dominant type in the above‐mentioned regions.…”

Section: Discussionmentioning

confidence: 52%

Distribution of virulence factors and association with emm polymorphism or isolation site among beta‐hemolytic group G Streptococcus dysgalactiae subspecies equisimilis

Cheng

2014

APMIS

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Distribution of virulence factors and association with emm polymorphism or isolation site among beta-hemolytic group G Streptococcus dysgalactiae subspecies equisimilis. Streptococcus dysgalactiae subspecies equisimilis (SDSE), the dominant human pathogenic species among group G streptococci, is the causative agent of several invasive and non-invasive diseases worldwide. However, limited information is available about the distribution of virulence factors among SDSE isolates, or their association with emm types and the isolation sites. In this study, 246 beta-hemolytic group G SDSE isolates collected in central Taiwan between February 2007 and August 2011 were under investigation. Of these, 66 isolates were obtained from normally sterile sites and 180 from non-sterile sites. emm typing revealed 32 types, with the most prevalent one being stG10.0 (39.8%), followed by stG245.0 (15.4%), stG840.0 (12.2%), stG6.1 (7.7%), and stG652.0 (4.1%). The virulence genes lmb (encoding laminin-binding protein), gapC (glyceraldehyde 3-phosphate dehydrogenase), sagA (streptolysin S), and hylB (hyaluronidase) existed in all isolates. Also, 99.2% of the isolates possessed slo (streptolysin O) and scpA (C5a peptidase) genes. In addition, 72.8%, 14.6%, 9.4%, and 2.4% of the isolates possessed the genes ska (streptokinase), cbp (putative collagen-binding protein, SDEG_1781), fbp (putative fibronectin-binding protein, SDEG_0161), and sicG (streptococcal inhibitor of complement), respectively. The only superantigen gene detected was spegg (streptococcus pyrogenic exotoxin G(dys) ), which was possessed by 74.4% of the isolates; these isolates correlated with non-sterile sites. Positive correlations were observed between the following emm types and virulence genes: stG10.0 and stG840.0 with spegg, stG6.1 and stG652.0 with ska, and stG840.0 with cbp. On the other hand, negative correlations were observed between the following: stG245.0, stG6.1, and stG652.0 types with spegg, stG10.0 with ska, and stG10.0, stG245.0, and stG6.1 types with cbp. The prevalence of emm types of SDSE in central Taiwan was investigated for the first time. Moreover, the distribution of virulence factors among beta-hemolytic group G SDSE isolates, as well as their association with emm types or isolation sites were also examined.

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“…The SD isolates described here all displayed betahemolysis and a majority are Lancefield group G and thus they likely all belong to the subspecies equisimilis [7], but since MALDI-TOF MS cannot separate this subspecies from subspecies dysgalactiae we chose not to indicate subspecies [8]. The types StG6, StG480, and StG485 prevalent in this study have also been reported to be so by others [2,12,14,20]. Type StG643 comprising 17 % of our isolates was very recently shown to be common in Norway [21].…”

Section: Discussionmentioning

confidence: 82%

Recurrent bacteremia with Streptococcus dysgalactiae: a case–control study

Trell

Sendi

Rasmussen

2016

Diagnostic Microbiology and Infectious Disease

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Distribution of emm Types and Genetic Characterization of the mgc Locus in Group G Streptococcus dysgalactiae subsp. equisimilis from a Hospital in Northern Taiwan

Cited by 15 publications

References 15 publications

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Molecular characterization and antibiotic resistance of group G streptococci in Israel: comparison of invasive, non-invasive and carriage isolates

Distribution of virulence factors and association with emm polymorphism or isolation site among beta‐hemolytic group G Streptococcus dysgalactiae subspecies equisimilis

Recurrent bacteremia with Streptococcus dysgalactiae: a case–control study

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