Distribution of<i>CFTR</i>Variations in an Indonesian Enteric Fever Cohort

Vosse, Esther van de; Visser, Adriëtte W. de; Al-Attar, Sinan; Vossen, Rolf H. A. M.; Ali, Soegianto; Dissel, Jaap T. van

doi:10.1086/651598

Cited by 8 publications

(9 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…S. Typhi, but not S. Typhimurium, binds cystic fibrosis transmembrane conductance regulator (CFTR), which facilitates bacterial invasion of intestinal epithelial cells 116 . The presence of at least one of four alleles known to affect CFTR expression levels -which are located at three loci: rs4646205, rs1805177 and rs113857788 -was shown to protect against enteric fever in an Indonesian population in a candidate gene study 117 . To date, this finding has not been replicated in an independent population, and alone this study does not represent compelling evidence of an association of enteric fever with the CFTR locus.…”

Section: Box 2 | Heterogeneity Of Susceptibility To Ints Disease and mentioning

confidence: 99%

Genetic susceptibility to invasive Salmonella disease

2015

View full text Add to dashboard Cite

Invasive Salmonella disease, in the form of enteric fever and invasive non-typhoidal Salmonella (iNTS) disease, causes substantial morbidity and mortality in children and adults in the developing world. The study of genetic variations in humans and mice that influence susceptibility of the host to Salmonella infection provides important insights into immunity to Salmonella. In this Review, we discuss data that have helped to elucidate the host genetic determinants of human enteric fever and iNTS disease, alongside data from the mouse model of Salmonella infection. Considered together, these studies provide a detailed picture of the immunobiology of human invasive Salmonella disease.

show abstract

Section: Box 2 | Heterogeneity Of Susceptibility To Ints Disease and mentioning

confidence: 99%

Genetic susceptibility to invasive Salmonella disease

2015

View full text Add to dashboard Cite

show abstract

“…A microsatellite polymorphism in intron 8, IVS8CA, of the CFTR gene was associated with protection from enteric fever (P ϭ 0.003) (24). In a further analysis of additional regions, the presence of one or more protein-expressing variations, including the IVS8 TG 11 TG 12 genotype, provided a modest protection from enteric fever (OR, 0.57; P Ͻ 0.01) (25).…”

Section: Epidemiology and Clinical Aspects Typhoidal Salmonellamentioning

confidence: 94%

Epidemiology, Clinical Presentation, Laboratory Diagnosis, Antimicrobial Resistance, and Antimicrobial Management of Invasive Salmonella Infections

et al. 2015

View full text Add to dashboard Cite

SUMMARY Salmonella enterica infections are common causes of bloodstream infection in low-resource areas, where they may be difficult to distinguish from other febrile illnesses and may be associated with a high case fatality ratio. Microbiologic culture of blood or bone marrow remains the mainstay of laboratory diagnosis. Antimicrobial resistance has emerged in Salmonella enterica , initially to the traditional first-line drugs chloramphenicol, ampicillin, and trimethoprim-sulfamethoxazole. Decreased fluoroquinolone susceptibility and then fluoroquinolone resistance have developed in association with chromosomal mutations in the quinolone resistance-determining region of genes encoding DNA gyrase and topoisomerase IV and also by plasmid-mediated resistance mechanisms. Resistance to extended-spectrum cephalosporins has occurred more often in nontyphoidal than in typhoidal Salmonella strains. Azithromycin is effective for the management of uncomplicated typhoid fever and may serve as an alternative oral drug in areas where fluoroquinolone resistance is common. In 2013, CLSI lowered the ciprofloxacin susceptibility breakpoints to account for accumulating clinical, microbiologic, and pharmacokinetic-pharmacodynamic data suggesting that revision was needed for contemporary invasive Salmonella infections. Newly established CLSI guidelines for azithromycin and Salmonella enterica serovar Typhi were published in CLSI document M100 in 2015.

show abstract

“…The organism interacts with the cystic fibrosis transmembrane conductance regulator (CFTR) that participates in the entry of Salmonella Typhi into the epithelial cell. A study in Indonesia performed genetic analysis of a case control cohort and showed that a specific polymorphism that affects CFTR seemed to confer modest protection against Salmonella Typhi [30].…”

Section: Pathogenesis Of Typhoidal Salmonellamentioning

confidence: 99%