Distribution of human papillomavirus types in anogenital warts of men

Chan, Paul K.S.; Luk, Alfred Chun Shui; Luk, Tommy N. M.; Lee, Kwong-Fai; Cheung, Jo L.K.; Ho, King Man; Lo, K. K.

doi:10.1016/j.jcv.2008.11.001

Cited by 62 publications

(69 citation statements)

References 28 publications

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“…The prevalence of HPV 6/11 in GWs in our study was 54%. Previous studies reported the HPV 6/11 prevalence in GWs to be 86% among young women in the placebo arm of an HPV vaccine trial [19], 89% in men from Hong Kong [21], 90% among French men aged 18-72 years [22], and .95% in 2 small US studies that included ,50 men [23,24]. We also observed a high proportion of oncogenic HPV types in GWs (33.1%), with HPV 16 (9.8%) being the most common type detected after HPV 6 (43.8%) and HPV 11 (10.7%).…”

Section: Discussionmentioning

confidence: 99%

Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Anic¹,

Lee²,

Stockwell³

et al. 2011

The Journal of Infectious Diseases

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Background. Data on the natural history of human papillomavirus (HPV)-related genital warts (GWs) in men are sparse. We described the distribution of HPV types in incident GWs and estimated GW incidence and time from type-specific incident HPV infections to GW detection in a multinational cohort of men aged 18-70 years.Methods. Participants included 2487 men examined for GWs and tested for HPV every 6 months and followed up for a median of 17.9 months. Samples were taken from 112 men with incident GWs to test for HPV DNA by polymerase chain reaction.Results. Incidence of GWs was 2.35 cases per 1000 person-years, with highest incidence among men aged 18-30 years (3.43 cases per 1000 person-years). HPV 6 (43.8%), HPV 11 (10.7%), and HPV 16 (9.8%) were the genotypes most commonly detected in GWs. The 24-month cumulative incidence of GWs among men with incident HPV 6/11 infections was 14.6% (95% confidence interval [CI], 7.5%-21.1%). Median time to GW detection was 17.1 months (95% CI, 12.4-19.3 months), with shortest time to detection among men with incident infections with HPV 6/11 only (6.2 months; 95% CI, 5.6-24.2 months).Conclusions. HPV 6/11 plays an important role in GW development, with the highest incidence and shortest time to detection among men with incident HPV 6/11 infection.

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Section: Discussionmentioning

confidence: 99%

Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Anic¹,

Lee²,

Stockwell³

et al. 2011

The Journal of Infectious Diseases

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“…PCR targeting the betaglobin gene was used to assess specimen quality. 9 HPV DNA was detected by PGMY primers in a 50-lL PCR mix containing Tris-HCl, KCl, (NH 4 ) 2 SO 4 , 1.5 mM MgCl 2 , 1 unit of HotStarTaq polymerase (QIAGEN, GmBH, Hilden, Germany), 200 lM of each dNTP (Amersham Biosciences, Piscataway, NJ), 0.25 lM of each primer and 5 lL of sample DNA. Cycling conditions were initial denaturation and enzyme activation at 95 C for 15 min, followed by 40 cycles of 1 min denaturation (94 C), 1 min annealing (58 C for Beta-GP1/2 or 55 C for PGMY09/11) and 1 min extension (72 C); and final extension at 72 C (8 min).…”

Section: Methodsmentioning

confidence: 99%

“…Positive samples were typed with the Linear Array HPV Genotyping Kit (Roche Molecular Diagnostics, CA) as described previously. 9 For the purpose of analysis in this study, high-risk HPV types included those with a probable oncogenic risk association reported and comprised HPV16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 69, 73 and 82. [10][11][12][13] For the analysis on age at diagnosis of cervical neoplasia, all surgical pathology records of 2 large regional government hospitals, designated ''A'' and ''B'' were searched to identify patients with histology-confirmed CIN2, CIN3 and invasive cervical cancer (ICC).…”

Section: Methodsmentioning

confidence: 99%

Age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies

Chan

Chang

et al. 2009

Intl Journal of Cancer

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Although a second age-related peak of human papillomavirus (HPV) infection is observed in many populations, it does not seem to have any impact on cervical screening policies. We examined the age-specific prevalence of HPV infection among 2,604 women enrolled for cervical screening and correlated the age at diagnosis of 2,491 cervical intraepithelial neoplasia Grade 2/3 (CIN2/3) lesions and 801 invasive cervical cancers (ICC). Two peaks of HPV infection were detected at 26-30 and 46-50 years, respectively. The first infection peak was followed by a CIN2/3 peak and an ICC peak at 5-15 and 15 years later, respectively. The second infection peak was followed by an ICC peak 20 years later, but strikingly no CIN2/3 peak was detected in between and thus eliminated an opportunity of treating the lesions at preinvasive stages. The most plausible explanation is that women at the expected second CIN2/3 peak (50-65 years) are not having Pap smears under the current opportunistic screening program. Furthermore, women of this age may have physiological retraction of the transformation zone, and CIN lesions may remain undetected if an adequate Pap smear sample is not obtained. To combat this problem, the screening program in Hong Kong needs to focus on women aged 50 years and older and a mop-up screening up to 75 years is necessary. Bimodal peaks of HPV infection and cervical cancer are seen in many countries and the analysis of populationspecific age distribution of CIN2/3 should be an integral exercise in evaluating the effectiveness of a screening program.Human papillomavirus (HPV) infection is a necessary cause of cervical cancer. 1 The infection is mainly transmitted by the sexual route and occurs most commonly in young sexually active individuals with peak prevalence in women younger than 25 years. 2,3 Interestingly, most studies have also observed a second less pronounced peak of infection among older women, mostly 55 years and older. 2 A few hypotheses have been proposed to explain this observation. First, hormonal changes associated with menopause might induce reactivation of latent HPV infection; however, this second peak has not been universally observed in postmenopausal women. Second, it could be attributed to changes in sexual behavior of women and their partners in middle age, but the occurrence of second peak did not correlate well with data on sexual behavior. 2,3 Finally, the second peak may be a reflection of population-specific cohort effects as it is not consistently observed across the world. 2,4 The underlying reason for this second minor peak is still obscure, and its potential importance has not been fully investigated. It has been shown that a3/a15 HPV types, including HPV61, 71, 72, 81, 83, 84 and 89, are more commonly found in cervical scrape samples collected from older women and these samples also contain more squamous cells. 5 Because a3/a15 HPV types are nononcogenic, the significance of the increased prevalence among older women is unclear. 6 Nonetheless, many studies have confirmed a second ...

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“…Highrisk HPVs such as HPV 16 and 18 and other HPV types can be found isolated or more often coinfected with HPV 6 and 11. 42 The Buschke-Loewenstein tumor (giant condyloma acuminatum or verrucous carcinoma of the anogenital region) is a clinically aggressive tumor, with ulcerated cauliflower-like lesions, often associated with fistulas and abscesses. They present exophytic and endophytic growth, local invasion and high recurrence rates.…”

Section: Iv2 Condylomata Acuminatamentioning

confidence: 99%

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

Leto¹,

Júnior²,

Porro

et al. 2011

An. Bras. Dermatol.

113

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Human papillomavirus (HPV) is a DNA virus that presents tropism for epithelial cells, causing infections of the skin and mucous membranes. Replication of HPV occurs in the nuclei of squamous cells and its life cycle is directly related to the differentiation program of the host cell. To date, nearly 100 different types of HPV have been characterized and there is a large number of other types that have not been sequenced yet. Besides being responsible for benign lesions of the skin and mucous membranes, HPV is also involved in the development of various mucocutaneous tumors: Bowen's disease, non-melanoma skin cancers and genital carcinomas. This review discusses the characteristics of HPV, malignant and benign mucous and skin manifestations caused by HPV, besides the main methods of detection and typing of the virus. Keywords: DNA Viruses; Papillomavirus Infections; Warts Resumo: O papilomavírus humano (HPV) é um vírus DNA que apresenta tropismo por células epiteliais, causando infecções na pele e nas mucosas. A replicação do HPV ocorre no núcleo das células escamosas e o seu ciclo de vida é diretamente relacionado ao programa de diferenciação da célula hospedeira. Até o momento, foram completamente caracterizados cerca de 100 tipos diferentes de HPVs e há um grande número adicional de tipos ainda não sequenciados. Além de ser o responsável por lesões benignas de pele e mucosas, o HPV também está envolvido no desenvolvimento de diversos tumores cutaneomucosos: doença de Bowen, cânceres de pele não melanoma e carcinomas genitais. Esta revisão aborda as características do HPV, quadros cutâneos e mucosos benignos e malignos causados por ele e os principais métodos empregados em sua detecção e tipagem.

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Distribution of human papillomavirus types in anogenital warts of men

Cited by 62 publications

References 28 publications

Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Incidence and Human Papillomavirus (HPV) Type Distribution of Genital Warts in a Multinational Cohort of Men: The HPV in Men Study

Age distribution of human papillomavirus infection and cervical neoplasia reflects caveats of cervical screening policies

Infecção pelo papilomavírus humano: etiopatogenia, biologia molecular e manifestações clínicas

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